[Wed Aug 24 17:20:13 2016] >Input file: TM3FB8CGD.pdb >TM segments: C434-460_C462-517 MAIDEN score = -12.1224 Below is the ranking list of the residue pairs and their related pseudo-energy (the lower, the better). This includes inter-chain residue pairs. The maximum (least favorable) pairwise energy value has been set to 10. See the MAIDEN software article: Postic,G., Ghouzam,Y. and Gelly,J.C. (2015) Biochimie, 115, 155–161. ----------- ---------------- BBeads pair Empirical energy ----------- ---------------- V454C-I466C 1.8073618708281 V490C-R495C 0.865768327477284 L452C-W493C 0.843753089706037 W474C-L487C 0.768143538420045 R458C-I466C 0.759417990079033 A479C-M502C 0.728301682639209 T480C-I506C 0.707646189492324 W493C-A498C 0.69972233192941 L446C-L472C 0.674090173784941 V454C-Y468C 0.66753364697925 Q464C-P489C 0.649528600203507 V499C-A504C 0.637237689081455 V443C-A448C 0.626529786066259 Q464C-L487C 0.612832166356041 L465C-P489C 0.598574300743028 A438C-F509C 0.595677913501896 T478C-V501C 0.574010669766848 A453C-W493C 0.558254162877063 W474C-A479C 0.55482437295837 L442C-A504C 0.554040457605071 V454C-L465C 0.529011471947634 Y451C-Y468C 0.524206168240415 V512C-A517C 0.518400282153021 S450C-S475C 0.51522931325264 L452C-E457C 0.510178603660849 A463C-V490C 0.504199554058627 A460C-V490C 0.493396197083111 R495C-V500C 0.488425658322966 A453C-T467C 0.485937095212269 L442C-S508C 0.46952560396116 A434C-V512C 0.465343891118094 V445C-S450C 0.46398534574314 A438C-T507C 0.462829466593182 A463C-Y488C 0.461644059088742 T480C-M502C 0.459248939921514 Q464C-Y484C 0.456426134853216 Y451C-A471C 0.453842895731436 V445C-A504C 0.441546411233865 A438C-L511C 0.437689778226875 L465C-R470C 0.433721473311139 S450C-L472C 0.432886896307243 V454C-A471C 0.429899953631903 A438C-V512C 0.426087222343245 A453C-V497C 0.423696356302051 T491C-C496C 0.422911619525777 V445C-V500C 0.412660810615716 Y451C-A456C 0.411425585170733 T478C-A498C 0.406418833595832 L446C-Y451C 0.406155309785507 A479C-V503C 0.405572801626395 V476C-V482C 0.398730085420637 T439C-S508C 0.39702713039633 A435C-A515C 0.396949558837945 L446C-V476C 0.395759642660477 A453C-R458C 0.392657962148946 W473C-M502C 0.392289767938793 W493C-V499C 0.390325075949229 E477C-P489C 0.386835439267188 S475C-V501C 0.383237447365821 W474C-V482C 0.382327035256421 T507C-T513C 0.382232776096707 A456C-A471C 0.373460994290219 L446C-V501C 0.370917044824345 A448C-A504C 0.366173010004263 L441C-A504C 0.363736811644108 A437C-A515C 0.363150900165885 S450C-T467C 0.35827857442399 A434C-L511C 0.356933947948635 A435C-L511C 0.355720406434261 A463C-P489C 0.355261383413469 I444C-G449C 0.35225140487587 A456C-W493C 0.351756222574707 L452C-G494C 0.347873801358558 A456C-L492C 0.344109335979462 A453C-I466C 0.343031073561929 L446C-S475C 0.337846008849847 L465C-A471C 0.331409081658828 A460C-T491C 0.328483959790619 A471C-G494C 0.327050050081726 R458C-L465C 0.322263607830126 Y488C-V501C 0.319267532193911 A471C-A498C 0.318301772579489 E457C-I466C 0.318258976646087 V476C-T481C 0.316764294509928 P469C-E477C 0.314012346854835 G449C-G505C 0.313227370798474 I444C-C496C 0.312331082304028 A453C-Y468C 0.311117479557511 E477C-F509C 0.310606550077095 A448C-G494C 0.310147300561512 I466C-A471C 0.309642999318019 L465C-Y488C 0.307078171743099 E477C-C496C 0.304756827624844 L447C-L472C 0.300726267009888 T478C-C496C 0.294120036614278 A453C-G459C 0.293213773711513 L472C-E477C 0.28953077830263 G436C-L516C 0.283456178578096 S450C-R470C 0.279567177216658 A456C-L465C 0.278453337510388 R470C-L487C 0.277061859581109 G462C-L487C 0.276897704393875 E477C-V482C 0.274958460362859 Y451C-P489C 0.27495519973993 E457C-W493C 0.271586027512974 C496C-M502C 0.270194455591898 P469C-Y488C 0.269107369543378 L452C-V497C 0.267561347563426 C496C-V501C 0.266471640478745 L465C-L487C 0.265941161476459 L455C-I466C 0.263535741929541 A453C-A460C 0.258240014506331 S475C-G485C 0.25601623553448 A453C-A471C 0.255645496083517 A434C-A515C 0.254520442165453 M502C-V512C 0.251920758469089 T467C-P489C 0.251180699033497 S475C-Y484C 0.25111268362888 Y488C-R495C 0.250098522586391 L442C-G505C 0.247906147658476 T439C-T480C 0.245895999405382 L447C-T467C 0.241999208734646 G449C-E457C 0.241556984716887 S450C-P489C 0.241472898663794 L465C-G485C 0.24138106321933 E477C-G483C 0.240655765815043 V500C-G505C 0.239683635366609 Y451C-A498C 0.233499296108267 T480C-G505C 0.231258999375147 Y451C-V476C 0.229170789380589 E457C-L492C 0.228885828129521 L452C-R458C 0.22855533247464 Y451C-V499C 0.227237718608068 V501C-I506C 0.227024862425087 T478C-G505C 0.226598781320778 I444C-V476C 0.226032717379623 T507C-V512C 0.224949732668352 E477C-Y484C 0.221787784215304 Y451C-T467C 0.218164019746151 L455C-P469C 0.216457763132836 M502C-T507C 0.213442358374062 G449C-A504C 0.210825793406778 V454C-T467C 0.210701837887955 V445C-S508C 0.210092206407699 V503C-S508C 0.209786956025045 T478C-G494C 0.206018009127421 A456C-T491C 0.205959323060347 C496C-I506C 0.205590345547366 Y451C-Q464C 0.205216409220282 A479C-G510C 0.20455291486113 A456C-G462C 0.203816316928336 S475C-L487C 0.203351383256651 L472C-P489C 0.201360700389258 W474C-Y488C 0.200643100004434 V454C-R495C 0.200327198952004 W473C-T481C 0.19987765165176 T439C-I444C 0.199626749167573 A460C-Y488C 0.199410463752581 E477C-V501C 0.198840775171555 A463C-D486C 0.197013288464217 E457C-A498C 0.194809615762086 W473C-Y484C 0.191341675248186 W474C-C496C 0.190163957704919 R458C-Q464C 0.18622996715297 A460C-T467C 0.183278319761626 V445C-V501C 0.1831815487275 L455C-C496C 0.182978518948955 A453C-T478C 0.182569081929971 S450C-Y488C 0.182097618369608 E457C-R495C 0.181378346119551 T481C-F509C 0.177803373376176 R470C-S475C 0.17637247612281 P469C-L487C 0.175732708386154 A463C-A471C 0.17508576458145 S450C-V500C 0.17459953959198 G449C-L472C 0.174575956102792 G462C-T467C 0.174533521627008 L452C-G459C 0.174147431685404 T478C-D486C 0.173574484033634 A471C-D486C 0.173308667601479 G459C-Y488C 0.173235290772321 A456C-A498C 0.169179607776648 T467C-L487C 0.167941853058537 A437C-G510C 0.167627313593593 V490C-V499C 0.16674475038761 S475C-R495C 0.165334116335298 A463C-G494C 0.165125038319847 L446C-V500C 0.164556126699267 L442C-W474C 0.164540979494992 Y451C-Y488C 0.164155043185524 T467C-T491C 0.163830533518256 G505C-A515C 0.163822200619354 S450C-R458C 0.163806659145323 G459C-T467C 0.163762595682894 S450C-L455C 0.163105888096831 A456C-Y488C 0.162262291619379 L446C-A471C 0.161806857218814 L455C-T467C 0.161782962908842 G494C-A504C 0.161636831452177 A438C-A515C 0.158529342256516 L465C-W474C 0.157994307166669 A438C-A514C 0.157872461860819 L442C-W473C 0.157452177546091 L447C-C496C 0.155139806226989 G449C-A479C 0.155004496822448 A437C-A504C 0.154302940000766 I444C-T478C 0.153297392502866 L452C-W473C 0.152784482035304 Y451C-W493C 0.152216731274343 L455C-P489C 0.150467824452489 A460C-R495C 0.150280068876261 A479C-I506C 0.150189383268574 V445C-V497C 0.150073480050187 V482C-A498C 0.149322525996108 A448C-R495C 0.148713443599699 A435C-V443C 0.147315474433901 G485C-G494C 0.146481571269684 Q464C-R495C 0.14644673561391 T480C-T513C 0.145798672742212 S450C-W493C 0.145377697413297 I444C-T507C 0.144579050409674 V443C-A471C 0.143816855320362 Q464C-G494C 0.143671921922361 T467C-D486C 0.143422449013968 A453C-V476C 0.141598565050064 A471C-R495C 0.141301344105335 A463C-R495C 0.140709893402687 S450C-C496C 0.139909075021613 Y484C-M502C 0.139373515330689 L441C-S508C 0.138594490790073 I444C-Y468C 0.137826291965458 W474C-G483C 0.136560749221929 Q464C-R470C 0.134287613813904 A479C-V512C 0.133587122582424 S450C-R495C 0.133571462161087 Q464C-P469C 0.133411377555037 A435C-A504C 0.131903638109727 I444C-A453C 0.130959857137839 L441C-V500C 0.129176893304817 A463C-Y468C 0.128945014521269 A479C-A504C 0.128607962215994 L447C-V500C 0.127642261660479 R458C-A471C 0.12699956343041 L455C-V490C 0.126297928628921 R458C-G494C 0.126120690711989 R470C-Y484C 0.125416134785866 L446C-L455C 0.125262875552627 W474C-R495C 0.124560724352075 G449C-V501C 0.12420515078902 V440C-V501C 0.124149890795346 Y468C-P489C 0.123813374858236 I466C-W474C 0.122528561956042 S475C-T480C 0.121938061298557 P469C-D486C 0.121509224525994 I444C-A498C 0.121309312457807 L487C-A498C 0.119683644338827 L472C-Y484C 0.119203337199598 A448C-W474C 0.118202218901726 A456C-S475C 0.117299207048475 A438C-V501C 0.117054374457664 S475C-V503C 0.117009865221926 A453C-L487C 0.116946852770012 L472C-V501C 0.11617524151482 V500C-S508C 0.115990538630861 A448C-G505C 0.115948753276385 A453C-G462C 0.115930490097009 L452C-P489C 0.115539862324595 W473C-G485C 0.113964526763813 A434C-A504C 0.113490000951869 L452C-S475C 0.11324349522929 A463C-R470C 0.113182636424384 V445C-G494C 0.112967622575197 T478C-R495C 0.112463767773454 T478C-M502C 0.112357318992927 T481C-V499C 0.111184114318202 E477C-L487C 0.110952810279864 G449C-E477C 0.110740729487371 A437C-A514C 0.109997352132075 V445C-P469C 0.109617683746059 L446C-L465C 0.109426523549624 V476C-I506C 0.108031798277342 V445C-T467C 0.107978329644284 A448C-T478C 0.107794198021217 V440C-G510C 0.107747864580318 A471C-V482C 0.10735208265071 A438C-V476C 0.106867851174388 W473C-Y488C 0.106044739779005 L472C-M502C 0.105699932637529 S475C-D486C 0.105622397291892 A448C-R470C 0.105282219548176 G436C-T507C 0.10508728457825 A435C-G505C 0.104320976065853 L442C-L452C 0.104161156676013 L447C-I466C 0.104140560047847 L441C-S475C 0.104071691145819 L442C-V497C 0.10374366447727 V497C-V503C 0.103316065243513 L465C-S475C 0.103227515755669 V454C-V501C 0.103083837986299 P489C-V500C 0.102988963554265 L472C-Y488C 0.102413551103284 V501C-G510C 0.102306349669395 G459C-G494C 0.0999455437783441 S450C-I466C 0.0997947003325245 L447C-V499C 0.0997040303854502 L455C-L472C 0.0983269339248105 S475C-G494C 0.0978391072696105 V445C-V454C 0.0972917576222256 A479C-L487C 0.0969935103982484 L442C-V499C 0.0968192607748466 V482C-T507C 0.0966714686977195 L487C-V497C 0.0964574538278538 S508C-L516C 0.0962194221348078 V443C-A498C 0.0961910945130167 G462C-G485C 0.0949694276588793 T491C-V499C 0.0947759780249298 L447C-L465C 0.0944341861241802 V440C-S508C 0.0940347758116511 L442C-L472C 0.0939553157213202 I466C-L492C 0.0938017842234385 A437C-L446C 0.093429959110483 S450C-A479C 0.0931844243820468 G436C-G510C 0.0926138834464476 T439C-A448C 0.0924610169486946 A435C-A517C 0.0923167463345873 T439C-A515C 0.0922403300968462 L472C-G483C 0.0921499847578779 I444C-A479C 0.09209767585258 I506C-L516C 0.0919133953711595 L441C-L472C 0.0917614569074141 R458C-C496C 0.0914436721379226 G436C-G505C 0.09140178365783 V454C-S475C 0.0913300989731507 T467C-E477C 0.091317749261933 V503C-T513C 0.0908531544792335 T481C-S508C 0.09079381277735 G436C-T513C 0.0902361248552786 T439C-G510C 0.0900176673083286 A448C-A479C 0.08990330504033 S508C-A517C 0.0897884946849206 E457C-V497C 0.0895503809094285 L455C-A498C 0.0893549080416054 T481C-A498C 0.0892078489614843 L446C-L487C 0.0888641800865932 G505C-T513C 0.0886833190417429 G449C-T478C 0.0885414769821291 V440C-G505C 0.0853698990499545 I444C-A504C 0.0842758169069611 G462C-G494C 0.0841559392083897 L447C-M502C 0.0836988278616915 Y488C-V497C 0.0836102841863652 L441C-G449C 0.0833038642819908 S475C-T507C 0.0832030513520139 R470C-T478C 0.0828904168575235 Q464C-L492C 0.0827449488959271 A434C-V443C 0.0827444425961064 T439C-S475C 0.0825581405874362 S450C-T491C 0.0824745944557292 L452C-Q464C 0.0812920637021497 A456C-P469C 0.0810774253662441 A479C-C496C 0.0809428269701475 L447C-G505C 0.0806971698799668 V454C-V500C 0.080556170110782 A471C-G483C 0.079969654846928 L455C-R470C 0.0798605955477019 I444C-S450C 0.0791584983033928 T467C-V497C 0.0788827071849463 A453C-L465C 0.0787686923790982 G449C-R458C 0.0777007203523035 G483C-V499C 0.0775301448524623 V476C-G505C 0.0774576640450979 L446C-S508C 0.0758943562577512 A434C-A517C 0.0753621124823756 L472C-V482C 0.0750495793552561 E457C-V490C 0.0750120294812771 Y488C-M502C 0.0749876167637564 L441C-V476C 0.0746482410631599 V443C-V512C 0.0745069465139485 L452C-A463C 0.0742472373271812 V443C-V499C 0.0739801371845417 V440C-T507C 0.0739047707406637 A479C-G494C 0.0737872995672078 G449C-S475C 0.0737800131059032 V445C-L472C 0.0736060055464769 W473C-L487C 0.073574113595658 G449C-P469C 0.0735349145653239 G462C-A471C 0.0735078809044354 P489C-M502C 0.0728483669794153 A479C-P489C 0.0726646366467865 I466C-A498C 0.0726212573894314 E457C-Y468C 0.0706225655249324 L465C-R495C 0.0702120390172399 E477C-V503C 0.0695275588994235 Y468C-T478C 0.0695066957363097 L472C-G485C 0.0693316301003506 L447C-E477C 0.0685666972987962 L452C-A460C 0.0685220406701537 G449C-L455C 0.0680265701125258 T481C-M502C 0.0678211286309365 L446C-I506C 0.0675611917424159 L446C-G494C 0.0674754118081342 L447C-A471C 0.0671106878851511 P489C-G494C 0.0670833315655184 L441C-A498C 0.0670029676386674 T480C-G510C 0.0669477390861464 L441C-G510C 0.066457190712212 A448C-M502C 0.0659913622102875 L447C-A456C 0.0659790868791179 Y451C-T491C 0.0658987046350954 G449C-W493C 0.0657347371609802 L446C-T467C 0.0657324194037303 V476C-C496C 0.0655210846927239 R470C-G483C 0.065237775831346 L455C-R495C 0.0648760424242028 R458C-A498C 0.0645207314088589 T467C-G485C 0.0634768002773001 L452C-V501C 0.0632525329077902 V482C-V503C 0.063239214197897 R470C-E477C 0.0629041551106142 A460C-A471C 0.0628423006668044 L472C-V500C 0.06261871959647 S450C-D486C 0.0623298079215933 A435C-I444C 0.0621460372458618 W473C-V497C 0.0610840426608843 V440C-G449C 0.0609353388951881 A463C-A498C 0.0593945773059037 I466C-V490C 0.059307262869214 R458C-W493C 0.0592705421754514 A438C-A448C 0.0586120976327891 L487C-G494C 0.0585293589607943 Q464C-D486C 0.0583439474935492 I466C-V497C 0.0581223201273815 G449C-V497C 0.0581130566012185 R495C-V503C 0.0579536468915656 G459C-L492C 0.0578504225005874 E457C-G494C 0.0572615017634487 L441C-A479C 0.0571108071526703 A453C-G494C 0.055640837576913 S450C-P469C 0.055620887874003 P469C-V476C 0.0553069557472152 R470C-P489C 0.0552753534464658 V443C-Y468C 0.0544369963866433 V443C-V503C 0.053469209705403 V445C-R470C 0.0530151342058644 A435C-L442C 0.0520265649874139 W474C-G494C 0.0517942886477227 V476C-G510C 0.0515620181647384 A437C-L516C 0.0508659813304386 A448C-A456C 0.0505928484524247 T480C-V499C 0.050589692104019 V476C-S508C 0.0505521059886833 L446C-I466C 0.0498941453073067 V476C-A504C 0.0497899214979149 Y451C-T478C 0.0484605087156269 S450C-V497C 0.0484485664704408 T480C-Y488C 0.0482567385562025 A463C-L472C 0.0482196009017493 L472C-G505C 0.0477245615446569 L446C-L452C 0.0474572067600675 A438C-A479C 0.0470168932222892 I466C-G494C 0.0464052824688101 G449C-Y488C 0.0461320810414207 V476C-G494C 0.0460973916627374 V440C-V476C 0.0458589998198597 G485C-T491C 0.0454699884293297 T480C-V501C 0.0446722025463404 G483C-V501C 0.0446201412114835 G459C-W493C 0.0443414552477011 V482C-V500C 0.0442644715112905 A448C-L465C 0.0440723452153928 L442C-S450C 0.0438419105415953 A471C-V497C 0.0436087285425275 A435C-I506C 0.0430240955626537 V445C-R495C 0.0414738477246617 A479C-L511C 0.0413392595220228 V440C-L447C 0.0412689880280483 T467C-S475C 0.0409605556897747 G462C-W493C 0.040834111742267 V445C-Y468C 0.0403483939858535 E477C-A504C 0.0399512628308214 P489C-V501C 0.0399216298909888 G436C-I444C 0.0396149436662392 S508C-T513C 0.0395558411791366 A438C-M502C 0.0392178973585109 V443C-M502C 0.0377616375941301 G483C-M502C 0.0376580852656669 L465C-V476C 0.0376273597576331 L472C-T481C 0.0371358956099788 G462C-R495C 0.0359766930279966 S450C-V499C 0.0359248490856302 L465C-C496C 0.0358793259219912 W474C-V503C 0.0356971766230743 T480C-L511C 0.0355488261793473 L487C-L492C 0.0354945389939321 A463C-G485C 0.0350404711742733 T439C-G449C 0.0345833238347018 A479C-Y484C 0.0344553459297372 A453C-V501C 0.033710055020852 L442C-A498C 0.0334256923714107 L472C-G494C 0.0327905816702083 V454C-V499C 0.0325898490001215 I466C-W473C 0.0319254750322759 A471C-T481C 0.0318913781569281 V497C-M502C 0.031818386163267 V497C-I506C 0.0316086175241743 T439C-L516C 0.0315980472348589 L442C-G510C 0.0312727138392455 G449C-I466C 0.0311502120470823 A456C-V490C 0.0308154311339059 W473C-A498C 0.0306493471077252 T507C-L516C 0.0306277232276755 L472C-D486C 0.0298363833594992 L487C-W493C 0.0297235515980322 I444C-T480C 0.0292007842161355 G462C-T491C 0.029111425165808 L441C-G505C 0.0290261343012226 L441C-F509C 0.0289271431150258 L452C-V500C 0.0288640517527474 A479C-Y488C 0.0281968153771555 L446C-W493C 0.0279986118471029 A456C-Y468C 0.027392007243662 S450C-L487C 0.02722895868871 E457C-W474C 0.0266424343403777 T480C-V500C 0.0264879386991286 P489C-V497C 0.0263644884369221 V443C-T478C 0.0261479689249704 M502C-G510C 0.0260081277843947 A448C-V503C 0.0257328458663793 A471C-A479C 0.0256881368084207 A504C-V512C 0.025465455786235 T439C-M502C 0.0253368945790915 V445C-T480C 0.0252463032172643 L455C-Y488C 0.0251480069430441 M502C-L511C 0.025022255436884 T467C-A498C 0.024952684977003 V440C-A479C 0.0249515585748616 G449C-A471C 0.0242798400777491 G449C-Q464C 0.024145197043782 T439C-V503C 0.0240563990675571 E477C-V499C 0.0233740364800183 V501C-F509C 0.0231137288542049 A453C-V500C 0.0229169170265264 A434C-G505C 0.0226554931233629 V454C-L487C 0.0225229406864331 V454C-Q464C 0.0223817203052148 A504C-L511C 0.0223449865116283 Y451C-R495C 0.0222404241164771 E477C-V497C 0.0221488911111892 L446C-V499C 0.021851619614206 T481C-R495C 0.0213743375102908 A437C-V503C 0.0210427461820721 T481C-Y488C 0.0201740484329047 A460C-G494C 0.0200417491755829 A471C-G485C 0.0193963569233073 T480C-L487C 0.0186581256815668 T478C-V503C 0.0183863657617263 T478C-G485C 0.0183772581308579 L447C-W493C 0.0183350641751003 W493C-M502C 0.0181570221195462 G483C-G505C 0.0179734019048094 V443C-E477C 0.0179065879872561 L442C-L447C 0.0175199253058258 A479C-V497C 0.0170281732837507 V445C-E477C 0.0163672965391379 E477C-V500C 0.0157282981137633 V440C-V503C 0.0156439879908712 V476C-T507C 0.0145815369896076 G436C-A504C 0.0141369412955732 A437C-V445C 0.0138107912792425 I444C-S508C 0.0137786218127198 C496C-G505C 0.0136478321314364 S450C-T478C 0.0136218725091632 E457C-A463C 0.0136183283291285 V445C-G505C 0.0128593874269534 R458C-P489C 0.0126965165846142 V445C-S475C 0.0122960668757326 G485C-A498C 0.01218285817848 V443C-L511C 0.0120840846068533 V440C-V500C 0.0116027327893828 V482C-A504C 0.0115381268438481 I444C-V501C 0.00994666844806602 A448C-C496C 0.00944001247087112 A453C-V499C 0.00920066495133387 Y468C-Y488C 0.00880878255834894 V445C-W473C 0.00877433559150331 P489C-V499C 0.00854396992886386 G449C-T480C 0.00848085762366901 A438C-V503C 0.00795674506793431 A437C-I444C 0.00762112521591973 A435C-V512C 0.00757093150938548 L465C-G483C 0.0072702529615154 T439C-V476C 0.00665488771433065 L446C-R495C 0.00663284979183576 Q464C-E477C 0.00615705858815008 V445C-F509C 0.00607904806700343 Y468C-W473C 0.00601541159295582 G449C-T467C 0.0058159623490921 G462C-D486C 0.00531596999076134 A479C-R495C 0.00511670558575883 P489C-C496C 0.00501953230165086 G462C-R470C 0.00437908492438144 T480C-V512C 0.00415588469106432 V445C-C496C 0.00412151609598244 T439C-V501C 0.00366447359458277 Q464C-G483C 0.00357833159467091 Y451C-W474C 0.00355749336520539 A448C-W473C 0.00331883931903398 L442C-T481C 0.00297049416094075 V497C-G505C 0.00282252680609218 V443C-T480C 0.00277735737721663 V443C-F509C 0.00235415404878303 G494C-M502C 0.00182829386098282 T478C-V499C 0.00110968894671704 S475C-S508C 0.00072500571293066 L455C-L465C 0.000488021280421691 F509C-A515C -0.000399475079961853 A448C-V499C -0.000709393268684799 L442C-Y451C -0.00079699663991839 L441C-V503C -0.00100997520404356 I466C-S475C -0.00103123471991218 L442C-T513C -0.00108805492527697 S450C-A463C -0.00125458246306298 R458C-V490C -0.00130046695210417 A456C-V501C -0.00176680576338484 T507C-A517C -0.00208953790766886 L447C-A453C -0.00226342945673297 A471C-Y484C -0.00227768570086262 G449C-G494C -0.00230970136237915 T491C-V500C -0.00314251821087153 L455C-G462C -0.00325330362644394 L442C-T478C -0.00337035447545908 S450C-Q464C -0.0039879701239558 Y488C-V499C -0.00437839027516151 Y488C-G494C -0.00501446574866271 A438C-T480C -0.00502138933272933 A434C-L442C -0.00532924068917406 T481C-V500C -0.00567542424144296 G462C-L492C -0.00570018916351511 L492C-A498C -0.00620954992261002 G483C-P489C -0.00624361384575445 V443C-A453C -0.00637639717003413 V440C-I506C -0.00792829777458337 A471C-V500C -0.00794349353358625 T491C-V501C -0.00818984911690634 V440C-A448C -0.00820672274058309 S475C-C496C -0.00830386917323253 A448C-V476C -0.00848563452140683 W473C-G494C -0.00867332105787355 Q464C-A471C -0.00900770654036442 A437C-I506C -0.00990179532469115 L442C-E477C -0.0107218673561464 R458C-R470C -0.010933521836648 S450C-A456C -0.0112156847229752 A498C-I506C -0.0130224013972962 A463C-P469C -0.0135551903947606 E477C-Y488C -0.013749395010267 T467C-L472C -0.0143299368748728 A438C-V445C -0.0143952763270905 A463C-L492C -0.0144014731461803 E457C-L487C -0.0145349158485142 L446C-V503C -0.0146649367126885 V503C-V512C -0.0150948318020729 Q464C-V497C -0.0152770976624859 A448C-A453C -0.0153611021476907 T481C-G510C -0.0157207892599498 A456C-Q464C -0.0158053351068137 L472C-A498C -0.0159412243127495 S475C-I506C -0.0169199275226997 L455C-Q464C -0.0170717085753525 A434C-I506C -0.0171250261065533 G436C-A514C -0.0182954510773947 Q464C-W473C -0.0183664656003237 G483C-V503C -0.0186640066854507 L452C-P469C -0.0189114963714907 L447C-T478C -0.0189723996598765 G449C-P489C -0.0192703148060018 L455C-S475C -0.0194244132937289 G459C-P489C -0.0199765029619721 L452C-R470C -0.0206068639230672 I466C-W493C -0.020702890510135 G449C-M502C -0.0207396108204767 E457C-S475C -0.0209899548993916 T439C-A514C -0.0209997982547767 L447C-G494C -0.021129869060768 A471C-V501C -0.0211586178756908 Y451C-V500C -0.0213427607589756 Q464C-S475C -0.0215268699019853 S475C-W493C -0.0222144514976503 A453C-M502C -0.0224674253466688 T478C-S508C -0.0234264916460714 A434C-L441C -0.0240261799990158 R470C-G485C -0.0241431781942825 E457C-R470C -0.0241676914235178 Y468C-W474C -0.0244372562719244 A437C-G505C -0.0248208618770593 W474C-V497C -0.0248830742635837 V440C-F509C -0.0249242595001222 A463C-W493C -0.0249561157407605 A471C-T491C -0.0258360831578155 S450C-W474C -0.0258798036774976 A453C-R495C -0.0259102690530748 A471C-C496C -0.0259542573813158 W473C-P489C -0.0260578998333241 A456C-V499C -0.0265308877623922 T467C-Y488C -0.0267724545733901 I466C-P489C -0.0268519142325969 A471C-V490C -0.02735805031049 T478C-I506C -0.0273752100710327 V454C-A498C -0.0275082491395561 A456C-R495C -0.0276086463534062 G449C-L492C -0.0276592906647868 G483C-A498C -0.0279448334819403 V445C-A456C -0.0283178341785542 A471C-V499C -0.0284065204193649 G449C-V454C -0.0288510254688017 I444C-V499C -0.0291037733489972 V482C-V499C -0.0293635447972371 T478C-G483C -0.0300563868949597 T439C-F509C -0.0301330927256694 V443C-T507C -0.0303273011150109 Q464C-V490C -0.0304028328000275 R495C-G505C -0.0304357599580163 W474C-G505C -0.0308221374097004 Y451C-A460C -0.0309019886484234 R458C-Y468C -0.0319850802382717 L441C-L511C -0.0324483049202335 T439C-V512C -0.0324519353387061 R458C-T467C -0.0327007552273384 G449C-T491C -0.033610655001028 C496C-A504C -0.0336132951241155 A435C-F509C -0.0339767135902802 V503C-F509C -0.0340631741912762 Y468C-A498C -0.0343697402361902 V443C-I506C -0.0345263247993479 S450C-G505C -0.0346299047277361 V500C-F509C -0.0349276813661241 G449C-L487C -0.0349780984232367 V454C-A463C -0.0359313558778762 V490C-V497C -0.0361755613285526 Y488C-W493C -0.0365414759004112 A453C-L472C -0.0371362674009376 T478C-G510C -0.0371932914000577 V476C-P489C -0.0374624858317358 V443C-V497C -0.0375997307176237 Q464C-W474C -0.0377589803444209 A456C-V500C -0.0378704977856872 A498C-T507C -0.0382039746328519 G449C-V503C -0.0387705492769506 L452C-A498C -0.0388093324575287 T467C-G494C -0.0388316680677274 L452C-L465C -0.0395815985566688 G485C-V490C -0.0396107642024415 A504C-T513C -0.0399026781355432 V440C-S475C -0.0400954782740017 V476C-Y488C -0.0402696699604874 V443C-Y451C -0.0402833302896024 S475C-F509C -0.0405179761637182 L446C-T507C -0.0406731181713607 A460C-I466C -0.0407583173175681 T478C-F509C -0.0408946658514839 A479C-T513C -0.0411742251488243 I506C-A514C -0.0414744108315883 A460C-W493C -0.0420503257278799 A471C-T480C -0.0423198928803261 L447C-A498C -0.0431110660859693 L452C-T478C -0.043541316885614 T478C-Y484C -0.0439134829204639 G436C-V445C -0.0444115580797151 E477C-S508C -0.0444818763583186 Y488C-V500C -0.0446189802939854 A448C-P469C -0.0465704846592013 L442C-T507C -0.0472241407113181 T480C-D486C -0.0472942332514803 A460C-L487C -0.0476354623767357 G505C-G510C -0.047756024148125 I444C-R470C -0.0484935198240164 L465C-A498C -0.0493835826400675 Y468C-V476C -0.0494033749661322 L441C-T480C -0.0497017210655653 E457C-T491C -0.0500570586449229 Y451C-L492C -0.0501295309878742 W474C-T491C -0.0507209010437797 A437C-V512C -0.0511006678796022 W473C-D486C -0.0515797648655079 L441C-T478C -0.0516240758133044 T481C-L487C -0.0522110463781509 W474C-V490C -0.0523969570143787 Y451C-R458C -0.0524936518362256 A448C-T467C -0.0532052283859938 A438C-A517C -0.0534237293268371 E457C-T467C -0.0537066884646045 I466C-T491C -0.0547257504967318 V443C-P469C -0.0548893489727162 V445C-T478C -0.0553002467481658 A456C-L487C -0.0554335406478499 A438C-L516C -0.0559123367812817 A438C-V500C -0.0559267875548408 I444C-V497C -0.0561826001401595 G459C-Q464C -0.0570333880517055 G494C-V503C -0.0570669036392619 L446C-Y488C -0.0571991654478086 T481C-G505C -0.0572001576955308 P489C-A498C -0.057443832848481 G449C-Y468C -0.0578224150135997 I444C-M502C -0.0580534146307954 L441C-I506C -0.058144909870145 L472C-T480C -0.0589076271925917 W474C-Y484C -0.05899874292284 A471C-M502C -0.059324880137837 A448C-W493C -0.0594750703524282 S450C-E477C -0.0596590521650806 A438C-L446C -0.0597884338739059 L446C-E477C -0.059868061487391 G505C-A514C -0.0603101289325552 G436C-A517C -0.0603399546202453 L446C-T480C -0.0608494858528283 V500C-I506C -0.0608766385197583 A479C-G485C -0.0609835544219091 L446C-A504C -0.0613665077450891 L447C-A479C -0.0617185327762551 V499C-G505C -0.0620557916379045 Y468C-G494C -0.0623121796629262 T481C-D486C -0.0625370240608909 T480C-G485C -0.0633026022675862 I466C-R495C -0.0637893619601941 T491C-V497C -0.0639880843420428 A448C-E477C -0.064278674622376 L472C-T478C -0.0644901146946495 L447C-R495C -0.0647370368959446 V476C-M502C -0.0653100166664569 Y451C-L487C -0.0656491494784675 Q464C-G485C -0.0658333581684585 L446C-W473C -0.0659962080980225 V445C-A453C -0.0661827108725168 L455C-Y468C -0.0663820509756556 A434C-F509C -0.0668050995784941 A453C-A479C -0.0672913146436529 R458C-R495C -0.067468712063578 S450C-V503C -0.0683359584123808 T439C-V500C -0.0689668382599269 T467C-V476C -0.0689754206058448 L472C-R495C -0.0690511749292071 T478C-V500C -0.0690640174600752 L465C-G494C -0.0694773752939764 S450C-E457C -0.0701153477053806 E477C-G494C -0.0701904034892273 V445C-A471C -0.0701957122424295 V499C-T507C -0.0711048158001246 Y451C-V501C -0.0714374595879428 L472C-V497C -0.0722645577243544 L446C-C496C -0.0729163577037744 T439C-L447C -0.0732705064237917 S450C-M502C -0.0746263352155685 R458C-L492C -0.0748221330070242 G436C-A515C -0.0750489673057601 V482C-P489C -0.0756101100140333 G462C-V490C -0.0760326355528731 A448C-Y468C -0.0761898469781591 Y468C-V497C -0.0764879693547177 Y451C-V490C -0.0766402254713006 L452C-R495C -0.0770328583221129 L441C-M502C -0.0771480969079081 V501C-T507C -0.0776803075485955 L487C-C496C -0.0781594520852393 V445C-T507C -0.0788282730261063 V499C-S508C -0.0788733681149627 L465C-E477C -0.0790534799230413 Q464C-A498C -0.0809089830971383 V476C-V503C -0.0809369659396442 R470C-A479C -0.0811634031537585 V482C-Y488C -0.0812490936593506 V476C-V499C -0.0813789927358558 I444C-L452C -0.0816731735163259 A453C-Q464C -0.0816886237730712 S475C-Y488C -0.0816914158266329 W474C-W493C -0.0818106391190564 W473C-T478C -0.0822812488164181 V443C-V500C -0.0828058975819888 A434C-T513C -0.0835351863237656 I444C-A471C -0.0835386364671198 A453C-E477C -0.084223402440061 L452C-V499C -0.0844520022967989 A498C-G505C -0.0864945721411048 W473C-V501C -0.0867715532429605 V454C-W473C -0.0872501091883042 G459C-R495C -0.0874267467149421 Y451C-A463C -0.0875826671689619 L472C-A504C -0.0879183205479031 V440C-V512C -0.0881606118555553 I444C-I506C -0.0894570379857242 A448C-E457C -0.0897826817910041 G436C-I506C -0.0898051233011086 L487C-M502C -0.0903178537508296 L446C-T481C -0.0906570625723282 A479C-V499C -0.0907762022826568 V445C-M502C -0.0908207184022096 G449C-V490C -0.0908955474520838 L455C-V497C -0.0910857528217619 L452C-M502C -0.0914352903548581 G494C-V499C -0.0915642581768727 L465C-L492C -0.0919960041695393 L492C-V501C -0.0925283816449749 T491C-A498C -0.0926976454573289 A435C-S508C -0.0934101037284165 L452C-L472C -0.0938851983075999 V445C-A479C -0.093909400378386 V482C-V501C -0.0939303924870492 R495C-V501C -0.0940276267756683 L447C-A504C -0.0943606544840749 A448C-V501C -0.0945518616982826 V454C-G459C -0.09468234953671 E457C-Y488C -0.0948956401413237 V476C-V497C -0.0949545782622599 V482C-F509C -0.0950326353955022 L452C-Y488C -0.0953569566716173 G436C-L511C -0.0958230471887731 R458C-A463C -0.0959121361912434 T480C-A498C -0.0962847738495016 A448C-I466C -0.0963676881023954 V443C-W474C -0.0968344425289021 S450C-A504C -0.0976417407461074 E477C-D486C -0.0977308229582683 G449C-A498C -0.0977483645007018 L452C-V476C -0.0982078161114632 Y468C-L487C -0.0983002498658612 A463C-T491C -0.098309411518765 S475C-G505C -0.0986060960655394 G436C-F509C -0.0986265129893944 V454C-W474C -0.0989397595546024 R470C-Y488C -0.0995036518273011 A456C-P489C -0.0995731750612545 Y451C-R470C -0.099840855579775 V476C-Y484C -0.099873309490973 V476C-V500C -0.100196648132685 R495C-M502C -0.100345521433097 T481C-I506C -0.100354689995835 W474C-I506C -0.10046119281671 L442C-A479C -0.100563481217888 A453C-T491C -0.10067788152392 A437C-T513C -0.100864459950062 V476C-F509C -0.10128208332278 Y451C-G459C -0.101711264967313 I444C-F509C -0.101771447477999 A456C-V497C -0.101772683213395 I466C-G485C -0.102211009066262 L472C-V499C -0.102474369469343 S450C-W473C -0.103300859337508 E477C-R495C -0.103371308355479 V440C-M502C -0.103980589704343 Y451C-L465C -0.104008234199601 L465C-T478C -0.104092956730668 R495C-A504C -0.104456063595519 L487C-V501C -0.104917489004502 V443C-L452C -0.104992652329815 Q464C-W493C -0.105242601775867 A453C-W473C -0.105384427787628 W473C-A479C -0.105439677796578 R458C-P469C -0.106051472826756 Y468C-E477C -0.106129086902041 L447C-V503C -0.106222384377012 A456C-W474C -0.106390968388097 S475C-V482C -0.106632657810687 T507C-A514C -0.106943433024529 G459C-I466C -0.107262953065423 L447C-Y468C -0.107631105631501 L441C-V497C -0.108330667039619 Y484C-P489C -0.10855513979521 S450C-V490C -0.109860365916072 V445C-L455C -0.110530270032944 L487C-V499C -0.111105068925258 L441C-V499C -0.111195013597381 V476C-D486C -0.11152246734534 R470C-V476C -0.11168598388047 G449C-V476C -0.111803670711687 V443C-G505C -0.112027008515081 G505C-V512C -0.11219875593546 Y451C-S475C -0.11260854154613 L441C-V512C -0.112827322408151 Y484C-A498C -0.113391788562902 V476C-G485C -0.113512512546551 L442C-A448C -0.113522496424244 Y451C-W473C -0.114221855981957 V443C-G449C -0.114550607218115 V503C-G510C -0.114994191075444 I466C-L487C -0.115895576446222 T467C-V490C -0.116496186679513 I444C-E477C -0.11690740492782 G436C-V443C -0.117407857759627 Y451C-I466C -0.117487907903105 G483C-R495C -0.117832589235907 T439C-A479C -0.118030024787147 L487C-R495C -0.11809297279461 W474C-A504C -0.118174169103988 T439C-T513C -0.118552253561699 L446C-Y468C -0.118879358502112 W474C-P489C -0.118984283076642 S475C-A504C -0.120041945827672 G436C-S508C -0.120225770045925 L442C-T480C -0.120458548959698 T481C-A504C -0.120766240436514 L452C-C496C -0.12091431012868 G483C-I506C -0.121281221580659 W474C-V500C -0.122878904618332 A460C-P489C -0.123124946421842 L465C-W493C -0.123204988435843 L446C-F509C -0.123448977352883 F509C-A517C -0.123826625704444 E477C-G505C -0.123928243030485 E477C-G485C -0.124659559215194 L446C-A456C -0.125302185282965 V454C-Y488C -0.125461750844427 V445C-W474C -0.125688140222184 L455C-W474C -0.126100017096282 A435C-G510C -0.126338650960659 S450C-A471C -0.126453885440679 L447C-L455C -0.126544666440271 S475C-G483C -0.127125935602116 A463C-W474C -0.127256313606191 T507C-A515C -0.127700733477536 T478C-Y488C -0.128013192361668 C496C-V503C -0.128484296556917 T439C-I506C -0.128662091799429 I444C-P469C -0.128793521892603 M502C-S508C -0.128931716747088 V482C-I506C -0.12901433736935 W493C-V501C -0.129685365448416 L442C-A471C -0.129977946589246 I506C-A515C -0.130031629535452 V443C-W473C -0.130739440872751 L452C-L487C -0.131308970111377 W474C-D486C -0.13164188767865 I466C-D486C -0.131937190769813 V482C-G505C -0.132266638354014 W474C-V499C -0.132498540385449 R458C-V497C -0.133225790823794 S450C-G494C -0.135981291582745 L446C-W474C -0.136370517942124 A453C-P469C -0.136435700045327 A479C-V501C -0.136949169626181 A471C-W493C -0.137898746775328 T481C-P489C -0.138037037898136 A479C-D486C -0.138446252779602 L441C-S450C -0.138581841851883 W474C-V501C -0.138706684397871 I444C-W474C -0.139900479120583 A434C-T507C -0.140371669503576 L455C-W493C -0.140882880869583 L452C-Y468C -0.141227710431043 A456C-T467C -0.14129610773801 T480C-V497C -0.141468178882532 G510C-A515C -0.141659511281674 V476C-A498C -0.142796121460119 V443C-A479C -0.143658161106793 W473C-V499C -0.143692416330109 G462C-Y488C -0.143783773245632 A437C-F509C -0.143892194938593 V445C-Y451C -0.144501609867777 A471C-T478C -0.144998770513444 A453C-W474C -0.145061692757351 E477C-I506C -0.14518060164167 A471C-E477C -0.14630375820713 I444C-W473C -0.146603703777611 G494C-V501C -0.146798856462469 T481C-V497C -0.147931307677547 L455C-L492C -0.148006674550944 R458C-Y488C -0.148153309836439 G485C-R495C -0.148193919057098 T480C-V503C -0.148907460998596 L447C-V454C -0.148911152244583 T480C-A504C -0.149035646579603 G510C-L516C -0.149290286340869 V490C-A498C -0.149292711356153 A435C-T507C -0.150260057117614 I444C-S475C -0.150730928043604 Y451C-L472C -0.151515206912488 G449C-V499C -0.151795038606832 A471C-P489C -0.152428660473994 S475C-P489C -0.153378769667109 A437C-L511C -0.153401514801358 I466C-L472C -0.154003025215029 R470C-D486C -0.154725718358759 R458C-L487C -0.154848375751224 R458C-T491C -0.155157208564964 E457C-L472C -0.155400066465805 Y468C-D486C -0.155849427314458 V482C-M502C -0.156554463946346 V454C-L492C -0.15750091376172 G494C-V500C -0.157579852567791 Y451C-E457C -0.157948559595422 S475C-M502C -0.158144872281637 A437C-T507C -0.158544905500322 R470C-G494C -0.158613800158416 P469C-T478C -0.159212594022601 T439C-V445C -0.160054247691296 V454C-G462C -0.160655435069873 L447C-L452C -0.160674466292658 A437C-V443C -0.161336831602471 Q464C-L472C -0.161364604415428 G449C-R470C -0.161767291171356 L492C-V497C -0.16296360832623 A456C-L472C -0.163509206484869 A438C-T513C -0.163526606059682 L442C-V500C -0.164199271868103 W474C-A498C -0.164369231367773 V499C-I506C -0.164964674963471 T481C-V501C -0.165238465705107 L441C-V501C -0.16525167613973 A438C-L447C -0.165447935093791 L446C-A498C -0.165515461983671 V445C-I506C -0.165577231806149 G449C-L465C -0.165580503441485 A453C-L492C -0.16627024831792 A453C-D486C -0.166301680192843 D486C-A498C -0.166600765474994 V454C-R470C -0.166675060327415 W474C-G485C -0.16694191147003 V476C-L487C -0.167110417768663 G449C-W474C -0.167235193727697 L472C-A479C -0.167861650136107 A456C-C496C -0.168103525949743 A435C-L441C -0.169218191870806 I444C-Y451C -0.170410985521932 I466C-Y488C -0.17157760014575 A479C-A498C -0.172182445184005 L447C-V501C -0.172339991926848 A453C-A463C -0.172726185551762 R470C-A498C -0.176527275821524 G449C-R495C -0.176969519344055 V454C-G494C -0.177676428597044 A456C-R470C -0.177684244377839 L447C-W474C -0.178079724942654 Y451C-G494C -0.178224881070748 V503C-L511C -0.179672125236531 I444C-L472C -0.181224745825223 W473C-G483C -0.182517665309697 L452C-L492C -0.183637442581469 V454C-W493C -0.183703531052856 V476C-V501C -0.183711833655591 S450C-L492C -0.184684253002608 L446C-P469C -0.184845307557872 V454C-C496C -0.185020498450208 L446C-G505C -0.186225845497429 A434C-G510C -0.186923625984506 V500C-T507C -0.186927516643946 T478C-V497C -0.187813004944711 A479C-G505C -0.188708302402707 A448C-A498C -0.188721914872405 E477C-M502C -0.189117442152587 E477C-T507C -0.190466910625808 L447C-R470C -0.190652527625137 W474C-M502C -0.19091719313485 A479C-T507C -0.192603200901246 A456C-A463C -0.19299083313733 L465C-Y484C -0.193016851966888 Q464C-T491C -0.194004988605466 T478C-P489C -0.194164162168428 L511C-L516C -0.196527577277497 W473C-G505C -0.196671507255579 G449C-W473C -0.197468741953185 G459C-V490C -0.197479631112043 A463C-L487C -0.197792488843515 L492C-V500C -0.198099347823798 V443C-L472C -0.198111096193172 V454C-P469C -0.198692722572963 Y451C-P469C -0.198859772314119 T478C-L487C -0.1991701845108 L446C-R470C -0.199720602983948 V454C-L472C -0.20031503201335 W473C-V500C -0.200432651212778 I444C-V500C -0.201153374128771 T478C-A504C -0.201525116376112 G462C-P489C -0.202060946073736 A453C-S475C -0.202122512354916 S508C-A515C -0.202307555487122 G459C-T491C -0.202756161398915 A448C-L472C -0.20288346261327 L492C-V499C -0.203786113554558 V440C-L511C -0.204029344968894 L446C-V497C -0.2048517225107 V482C-L487C -0.205123967923885 V445C-W493C -0.206073657977069 A453C-R470C -0.208218693258364 L452C-A471C -0.208886961603552 V454C-P489C -0.209422885509058 L442C-V476C -0.209731395855028 T439C-A504C -0.210414141640151 I444C-V503C -0.210422487162578 V454C-V490C -0.212322315572933 A448C-S475C -0.213389124607428 E477C-A498C -0.214907721975835 S508C-A514C -0.215324016848588 A456C-G494C -0.215792511589072 W473C-T480C -0.215834230576792 A448C-V500C -0.218483265072221 G483C-Y488C -0.221400204232325 L455C-A460C -0.221682747335519 R470C-V501C -0.22174824160709 L442C-L511C -0.223111768643038 Y451C-V497C -0.223715863883664 L441C-A448C -0.223779955226966 A434C-T439C -0.224100316277004 G436C-V512C -0.225300217029181 L442C-S475C -0.225473545050479 E457C-G462C -0.227204868706682 S450C-A498C -0.227738085011158 F509C-L516C -0.227984298993327 T480C-F509C -0.22871293003431 G505C-L511C -0.229222875057414 L446C-V454C -0.229641933872255 S475C-A498C -0.229818657269426 A479C-V500C -0.229922581641484 L452C-V490C -0.2305484693875 L442C-V512C -0.230909191970262 A453C-C496C -0.231344232730133 L446C-A479C -0.232667393831777 L465C-D486C -0.232735972142677 S450C-Y468C -0.233985721978655 Y488C-A498C -0.23437419558373 L465C-V497C -0.234484308790908 A438C-I506C -0.236443200774602 L442C-F509C -0.237444089238427 L452C-T491C -0.237714462199706 V476C-G483C -0.238844729435514 E457C-D486C -0.239610115270674 A498C-A504C -0.23966984370437 V454C-V497C -0.239702964526903 T480C-S508C -0.239847691319169 L455C-A463C -0.240220547498811 L447C-V497C -0.240508701456957 A448C-L455C -0.240724552643755 Y451C-C496C -0.240993645486606 I506C-T513C -0.241464300814389 L455C-T491C -0.241898169890156 A448C-A471C -0.243224122479257 A453C-Y488C -0.243571025215249 G449C-V500C -0.243935747112538 R470C-V482C -0.244024692488972 T439C-G505C -0.244513252200228 A434C-L516C -0.244822727826258 V454C-T491C -0.246961565120102 L442C-G449C -0.250110701425173 G510C-A517C -0.250790445897777 T439C-L511C -0.25300926435609 A437C-L442C -0.254944979445658 S450C-L465C -0.255084146083535 L452C-W474C -0.258201149344901 V445C-L452C -0.259287469383789 A435C-A514C -0.259847767972326 G449C-A456C -0.260514756451005 A471C-Y488C -0.261389834944878 S450C-V501C -0.262129920960469 A504C-G510C -0.265609912442717 A460C-L492C -0.267655303653589 V440C-A504C -0.268019875083572 T481C-V503C -0.268205829969534 Y488C-C496C -0.268992120745522 V440C-V445C -0.26948343194586 W474C-T480C -0.270692899999343 R470C-V497C -0.272321445406206 V443C-S475C -0.273213886856697 L446C-T478C -0.273503228209994 L447C-S475C -0.273527545293884 L452C-I466C -0.27356175631259 S475C-V499C -0.274049577256127 L455C-A471C -0.274083986564748 T467C-W473C -0.276197420637867 W474C-T481C -0.276359042583361 I444C-G505C -0.27904563129526 E457C-A471C -0.281589212047096 L465C-T491C -0.284816786297656 S475C-T481C -0.284924409941943 G436C-L442C -0.28594301807976 S450C-V476C -0.287162832600609 V476C-R495C -0.287640421849034 L447C-V476C -0.287797813056982 A460C-L465C -0.287954799278755 V443C-R470C -0.28895358621409 T439C-L446C -0.289363380750839 L465C-W473C -0.290591355359543 A498C-V503C -0.291455794350714 L511C-A517C -0.291471870759556 Y468C-S475C -0.29203596931712 A471C-L487C -0.297049169046141 E457C-P489C -0.297852114553195 L446C-M502C -0.298012445587229 A435C-V440C -0.299603019927178 A435C-L516C -0.301609679587149 L446C-A453C -0.304160346370162 E457C-Q464C -0.305715341569454 L441C-T507C -0.307254160384129 L452C-T467C -0.307757777887282 V501C-S508C -0.309855720749582 T467C-W474C -0.311214718156952 L442C-I506C -0.31594877934866 M502C-F509C -0.317684712261059 A448C-V454C -0.317718995787491 Q464C-Y488C -0.319262795095896 L465C-V490C -0.319792769311976 V445C-V499C -0.320332316650148 V443C-V501C -0.321658217956103 V445C-V476C -0.324895866083431 L455C-G494C -0.325566976853958 W473C-V482C -0.326339691099175 T439C-T507C -0.32694526123205 G459C-L465C -0.327405288738568 P469C-W474C -0.327631444965827 G449C-C496C -0.327697125552196 L447C-W473C -0.327795474321154 V443C-S508C -0.32824012774288 A434C-V440C -0.328784277494153 V443C-S450C -0.329423830329006 A453C-P489C -0.331166153619392 A438C-G505C -0.33268041502302 P469C-S475C -0.336542080111695 A438C-I444C -0.33940991472782 F509C-A514C -0.342120003492575 S475C-V500C -0.342661872993446 V445C-V503C -0.346148013840113 V443C-V476C -0.346410147753239 A435C-T513C -0.351224254978393 S475C-V497C -0.351893977834975 L442C-V503C -0.353582657392082 V497C-A504C -0.356098657812449 A456C-I466C -0.356720875530478 A453C-V490C -0.356944847301406 E457C-P469C -0.357273399197496 A453C-A498C -0.358585552366129 V445C-A498C -0.363656523799749 V454C-A460C -0.364979515735401 A438C-G510C -0.367608251084132 V443C-A504C -0.369579056036358 A471C-V476C -0.372662210317056 T480C-T507C -0.373062901486122 A437C-S508C -0.373318959351423 T478C-T507C -0.382667718929712 L465C-L472C -0.384882562665622 I506C-L511C -0.384952464860535 L442C-M502C -0.385204185541877 A438C-A504C -0.387498679303355 L441C-L446C -0.398756006116468 G436C-L441C -0.399745652846566 W493C-V500C -0.401043186140548 I506C-V512C -0.407635163473914 V440C-L446C -0.41004262129703 A434C-A514C -0.419062743493591 A438C-V443C -0.421584898531854 A434C-S508C -0.422495318056873 L472C-L487C -0.42401140803808 A504C-F509C -0.432355034426485 L441C-L447C -0.438743597517682 L442C-V501C -0.445456547279262 A448C-V497C -0.447333385799703 A479C-F509C -0.458741099182822 V490C-C496C -0.460091871549842 A438C-S508C -0.464626347205281 T481C-T507C -0.494151326821741 L447C-P469C -0.527533803010948 E457C-L465C -0.540905139904523 A479C-S508C -0.542432275359347 E457C-C496C -0.571331342443125 P489C-R495C -0.593394911696894