[Fri Aug 26 16:40:43 2016] >Input file: TMA0A0D8Y1I3M1D.pdb >TM segments: 87-110_ 153-174_ 209-232_ 253-272 MAIDEN score = 8.9384 Below is the ranking list of the residue pairs and their related pseudo-energy (the lower, the better). This includes inter-chain residue pairs. The maximum (least favorable) pairwise energy value has been set to 10. See the MAIDEN software article: Postic,G., Ghouzam,Y. and Gelly,J.C. (2015) Biochimie, 115, 155–161. ----------- ---------------- Calpha pair Empirical energy ----------- ---------------- C219 -Y260 10 H224 -S230 10 L221 -Q226 6.47342538748342 C219 -Y259 2.00595355294167 P222 -L229 1.85302790684971 I161 -I166 1.09056364747088 L221 -L228 1.05805894946871 I156 -I161 0.963620269325926 F223 -Y259 0.900924465783288 F223 -C257 0.804737551566447 L221 -R227 0.704781106379897 W95 -I100 0.699263437332341 F223 -L228 0.696738529794589 A159 -F164 0.678021331443308 A101 -F163 0.67734314462709 F223 -L229 0.665991396342115 F223 -G256 0.665650256472659 V212 -N266 0.661607210151452 W220 -I225 0.623727785131678 F223 -S230 0.575838764213489 H224 -L229 0.56415741765507 H224 -C257 0.554479297792397 F223 -Y260 0.552484766576657 F158 -F163 0.542725608325068 F216 -L221 0.539158285848186 F160 -M165 0.532599698904387 L229 -Y253 0.52692245739963 I155 -F160 0.518932395698602 A101 -F158 0.507223449223534 C219 -N262 0.505927672839061 I97 -F163 0.429602183826464 S153 -F158 0.423357570788511 A162 -P167 0.417149443550569 V212 -L269 0.411334497201111 Q226 -V231 0.407628724505962 R227 -F232 0.407420617104949 S98 -I103 0.407288741928401 S230 -Y253 0.406003367730062 M165 -W220 0.397128714522273 H224 -S261 0.384783506595029 F163 -I225 0.373120783489663 F164 -I225 0.361691715808101 S211 -P267 0.355414001227575 S255 -Y260 0.345839861218076 V213 -Y270 0.345752329781247 S157 -A162 0.337259493780361 I254 -Y259 0.335319249282368 C219 -S263 0.305040259629374 A168 -L173 0.287375131044334 P167 -Q226 0.284543147412003 F164 -C219 0.276902497546137 L221 -L229 0.265615354314023 P222 -N262 0.256250610467418 A102 -A162 0.254757338512716 A87 -I92 0.252153950050222 P222 -C257 0.249070270732742 S215 -L269 0.247094586513213 L229 -S255 0.245756510035299 F216 -C257 0.242814809221096 F164 -R227 0.236879481853529 S215 -N262 0.236576599501229 S99 -A159 0.22539161423528 L229 -G256 0.224997927666585 Q226 -Y253 0.223897903902412 W220 -Q226 0.223318658443496 F232 -C257 0.223118878382815 A101 -S153 0.218088863791996 S157 -P167 0.215747106977719 S153 -S230 0.215679216990475 F216 -A264 0.208647590041608 Y88 -I93 0.205198517759007 F164 -V231 0.203517646461907 S255 -N262 0.201720255935371 L221 -N262 0.201626898491422 N262 -L269 0.20004572912783 W220 -G256 0.196460225078117 H154 -V231 0.194817041579847 F160 -R227 0.187615040125446 P222 -L228 0.18695974805485 M165 -S230 0.182025923828337 A264 -Y270 0.179885465148092 H154 -A159 0.179524190419705 M165 -V231 0.1776100436787 F217 -Q226 0.176529053711649 S263 -Y270 0.173867143266182 I97 -A159 0.172260924568561 P167 -R227 0.172240264115408 P167 -L221 0.171983990038084 A159 -S230 0.168253947030468 Y253 -S261 0.167674547125175 S98 -M165 0.167124334918187 P222 -S263 0.165555304732164 C219 -Y253 0.165551225638246 M165 -L228 0.16450359539163 F158 -F164 0.164001775346242 G256 -S263 0.163910242877551 A101 -A162 0.163724380358621 C219 -L229 0.163647143591681 V213 -S263 0.15996591784326 H224 -Y259 0.159204132772682 I214 -N266 0.158504638310193 Y253 -Y259 0.158401865628326 I156 -I166 0.158079604828451 L218 -S255 0.157271275491864 P222 -S230 0.156528639894917 I100 -I155 0.156159894148439 I97 -I161 0.155895663430294 V213 -Y260 0.154318822886049 W220 -S255 0.153251789896958 S215 -P222 0.151903023895777 M89 -S98 0.151251437477926 I103 -A159 0.151171767571487 F163 -S230 0.151052473092991 I97 -A168 0.149864578026835 M94 -I171 0.14950280649334 I97 -I225 0.148928949267106 A162 -R227 0.148876248194416 P104 -S157 0.148594154913581 I103 -H154 0.148099917547458 I214 -I265 0.147319568546385 I96 -I103 0.146791925250007 A168 -R227 0.146329444376542 I97 -I166 0.146253282672234 I171 -V210 0.145867714408121 I100 -I166 0.145188212914207 S215 -A264 0.144756485275011 A102 -I225 0.142685066613086 I166 -I225 0.141730904263831 F258 -A264 0.140034288178601 A168 -V212 0.136767347847465 M94 -A101 0.135031754260922 F223 -Y253 0.131724014223641 C219 -S230 0.130365483976112 V231 -C257 0.129836651436188 S261 -N266 0.129041659363975 L221 -I254 0.128584625354944 F163 -F217 0.127753705363255 V213 -L221 0.127592711206103 V210 -L269 0.127564605048711 I225 -I254 0.126773073186025 A162 -H224 0.126253554007101 H224 -V231 0.126084996505631 I214 -Y260 0.126033468754085 I214 -Q226 0.125606753543648 W220 -Y260 0.123755924495239 I156 -I225 0.123144592211275 F217 -C257 0.123086743454717 S98 -F160 0.122842110058994 I225 -S261 0.1226856123425 S99 -P167 0.122536132361265 L218 -L269 0.122106039039409 S157 -S230 0.121956789855157 A168 -V210 0.121781433441654 F217 -S261 0.120608203702257 A87 -W95 0.120518981860953 S230 -F258 0.119797484390712 A264 -N271 0.119094447690812 S98 -A168 0.118077084403543 S263 -L269 0.115824557852536 C257 -I265 0.115515199467424 S211 -L218 0.115436224085559 Q226 -S261 0.112117981838288 A101 -Q226 0.11186807996888 S157 -V231 0.111163550264579 A102 -I108 0.110577520331131 A168 -S215 0.109331824328981 A168 -I214 0.107900331739588 P104 -H154 0.107569837521228 H224 -S255 0.106909479760891 S230 -Y259 0.104326002086985 S215 -F223 0.101893096703769 A102 -I155 0.101505110679393 I171 -V213 0.101227188406614 L170 -V210 0.100695156579886 I103 -I155 0.100024883305174 I91 -S99 0.0992842074503137 A168 -W220 0.0990395696470925 V212 -Y260 0.0958761264964352 L221 -Y260 0.0952757102550246 R227 -Y253 0.0949008096913921 S157 -Q226 0.0947771012095284 F217 -P222 0.0946874195989627 I169 -L221 0.0938017842234385 P104 -A162 0.0935779506408143 I171 -L221 0.0923693708317982 I225 -S230 0.0917372056098293 A101 -H224 0.0915644030293787 A168 -L221 0.0908728537404766 Y259 -N266 0.0901273811552423 Q226 -C257 0.0900429472907545 V213 -L269 0.0898421499023936 H224 -F232 0.0897150792660888 L228 -S255 0.089048013265254 V213 -Q226 0.0885406498938459 A162 -V231 0.0884403636176256 S215 -Y259 0.087520640488977 A101 -A159 0.0874519261435844 I156 -H224 0.0871622239058416 L229 -Y260 0.0870258207882157 H154 -S230 0.0853652963786793 S215 -N271 0.0846684251155088 I100 -H154 0.0843284855410133 T90 -S99 0.0843010570666718 V212 -L221 0.0841170700845932 Y88 -W95 0.0837341524677582 A168 -L228 0.0827535378654085 M94 -A102 0.0823064275208116 P167 -T172 0.0805897153225441 I96 -A102 0.0804049330671499 T172 -S215 0.0803889116591724 S153 -V231 0.0801451871534598 F217 -G256 0.0798715522723752 S230 -S261 0.0788226810351382 I92 -A102 0.0787211712624591 P222 -V231 0.0786421295765541 Y88 -I97 0.0786318553390375 I156 -L229 0.0785169074151222 I100 -A159 0.0783378519628055 S215 -Y270 0.0777624360857105 S153 -I161 0.0774585655623223 S211 -S263 0.0763434936629173 S255 -S263 0.0755572008201062 Y253 -N262 0.0754574215343444 S215 -G256 0.0753285700692905 A162 -L170 0.0752920983414347 F164 -Y260 0.0744341087006717 W220 -I265 0.0743256005874237 A101 -F107 0.0735844086084558 I93 -A101 0.0735677422676089 Y260 -P267 0.0731891711233756 I97 -I171 0.0712376945172055 A162 -I171 0.0706852598834402 V212 -N262 0.0700688264206788 V231 -Y253 0.0696873691775646 S153 -A162 0.0684533773643432 F216 -G256 0.0678818958553125 I93 -I171 0.0677730385644519 F164 -L229 0.0670665681548703 M165 -I214 0.0670121889218906 S255 -S261 0.0668513642989064 I171 -S215 0.0667901869257426 I92 -A101 0.0658497111838381 L209 -I214 0.0657590293082007 S98 -I166 0.0655101005461398 F160 -P222 0.0652268561087608 F158 -A168 0.0649413091720543 S211 -N266 0.0645350795610806 L218 -A264 0.0642016382078396 M94 -I225 0.0641376519633017 L209 -V272 0.0639875306891291 A101 -I108 0.0639695353980221 S98 -I105 0.0639562670286595 F163 -T172 0.0621398467696879 H224 -S263 0.0613749927373788 I155 -F223 0.0611606915057912 C257 -A264 0.0604766204586995 L209 -I268 0.0601737119474097 I100 -I225 0.060069653231543 G256 -A264 0.0593991646097705 S211 -I265 0.0592363231236339 P104 -S153 0.0584813644996505 C219 -L269 0.0577810449714518 I156 -P167 0.0577238544756349 A101 -M165 0.0570323208343178 I155 -L228 0.0565997017744648 V231 -I254 0.0563141937009748 S211 -N271 0.0557876060546592 S230 -I254 0.0555636361591993 F223 -A264 0.0553550503972824 V210 -C219 0.054188083171093 I155 -F163 0.0539028582270786 A159 -I225 0.0538874557865565 A159 -A168 0.0536594578738407 F223 -N262 0.0533108395305676 M174 -S211 0.0529170005485717 L229 -Y259 0.0513857331112555 I155 -S230 0.0511688834357003 M165 -F223 0.0488803628180545 M165 -F216 0.0478826951162968 A159 -F223 0.0473403899508877 A162 -I225 0.0472445285715284 F217 -F223 0.046048941835366 I156 -L228 0.0460454501342298 I100 -I156 0.0460221113142447 F163 -F223 0.0458821044759983 I100 -S157 0.0457634229633106 L218 -S261 0.0443807126398623 S153 -F163 0.0441769015809435 S230 -Y260 0.0428163491323215 A168 -L218 0.0419153454233403 I100 -P167 0.0418795710757105 H154 -F164 0.0417810585926628 I96 -P104 0.0410258482481574 F216 -I268 0.0409919885342607 W95 -G106 0.0403418747616815 I161 -L228 0.0400772566968763 I105 -K110 0.0399687306421712 C219 -A264 0.0391009923451753 Q226 -F258 0.038178759180703 A159 -P167 0.0381086798086976 I100 -M165 0.038092968383145 N262 -Y270 0.0380201416981312 I254 -N262 0.0378406326946195 I156 -Q226 0.0375486203302329 P104 -F163 0.0374232199790172 I96 -P167 0.0369679361413144 I169 -F217 0.036806805314141 I169 -I214 0.0367886872503531 I100 -A162 0.0362746444153341 I171 -V212 0.0361921407126387 S215 -V272 0.0358097269858231 S215 -Q226 0.0357617796211604 S230 -S255 0.0353774262117503 W220 -N262 0.0353068184796506 T90 -I171 0.0352678211407769 I155 -M165 0.0337661163348688 A102 -F164 0.0334291290547428 M94 -A168 0.0321524780857692 A168 -Q226 0.031967048101321 F163 -L221 0.0315156627656787 F216 -L228 0.031225230517089 W220 -F232 0.0310118278815861 L221 -S255 0.0309935827136258 F164 -Q226 0.0307939734395477 I225 -S263 0.0305745823041672 P104 -F158 0.0304691113550646 F217 -F258 0.0287182691399273 Y260 -N266 0.0285596808270547 L221 -S261 0.0284561748300439 H154 -M165 0.0283501839935556 V213 -I225 0.0278342265312315 I93 -L170 0.0275027260123686 I97 -A162 0.0269701379114906 L221 -S263 0.0266030626152647 S98 -G106 0.0265577180686751 V213 -L218 0.0263254913874018 T172 -V213 0.0262196428632619 P167 -F217 0.0257267449660075 F158 -Q226 0.0255081116746518 P167 -V213 0.0251930214558378 S99 -G106 0.0251730628521845 A162 -Q226 0.0246456234493722 M174 -L209 0.0246150509133445 A101 -P167 0.0239340406654431 Q226 -S255 0.0238553684225549 S99 -H154 0.0237897476143245 I214 -V272 0.0230382891094347 I214 -R227 0.0221980117138338 I169 -R227 0.0206676414177603 I214 -P222 0.0205422065639196 T172 -F216 0.0205267879781056 V210 -Y270 0.0203452010851732 F158 -V231 0.0201635713211048 I166 -Q226 0.0197039919064435 I156 -F232 0.0188277132426206 C219 -S255 0.0187731255432499 L218 -H224 0.0183771052013405 H154 -I225 0.0179745062516314 L170 -V212 0.0174935132707574 S98 -H224 0.0170321367477309 P104 -K110 0.0169204953473101 V213 -I265 0.0158555076464506 A101 -I156 0.0152362119521152 C257 -S263 0.0151960484821503 L221 -Y253 0.0143639658212082 F164 -V213 0.0139531512236051 S98 -F158 0.0133809512368094 C219 -S261 0.012840206760047 L218 -F223 0.0125946824777818 I103 -A162 0.0124419848249211 S99 -F158 0.01235999193413 H154 -R227 0.012014661655964 S99 -A162 0.0117659157626029 I171 -F216 0.0116594554137111 I155 -L229 0.0114291536165423 F164 -F223 0.0114167479082878 I100 -I105 0.0111018416331046 I93 -P167 0.0109845930194978 A159 -L221 0.0108388628688481 S215 -S261 0.0105243868338538 S98 -Q226 0.0104499104914586 L209 -L218 0.010257218093094 M94 -F164 0.0102394867096725 S157 -I225 0.0101806667873561 I97 -F160 0.0099912868620482 A102 -S153 0.0096755715653547 S215 -P267 0.00902939855101259 I166 -L221 0.00888046249015861 S211 -V272 0.00874016669931699 S211 -C219 0.00796959148491649 M94 -P167 0.00770616480188857 F216 -R227 0.00735119991811928 A102 -V109 0.00693710701499839 S157 -F163 0.00685606528319682 I100 -G106 0.00675510839633153 W95 -F163 0.00664212400871012 H224 -G256 0.00656291757932159 M94 -L170 0.00605223392036791 I97 -P104 0.00462458303688384 F160 -I225 0.00454285370359919 N262 -I268 0.00446104597268082 V210 -S215 0.00435971046418793 I96 -F163 0.00431020842716778 L218 -I268 0.00332407334279772 V212 -N271 0.00278586266465553 H154 -H224 0.00137212325301839 F216 -I225 0.000438241218544189 I93 -F163 0.000341988723233655 L228 -F258 -9.17215253295467e-05 A168 -C219 -0.000487454603278703 S215 -L228 -0.000872980956534666 S99 -P104 -0.00151957860796426 I105 -H154 -0.00243514100443809 A101 -G106 -0.00283132331829172 I100 -F158 -0.00327726973159237 F164 -T172 -0.0033915735162009 V212 -W220 -0.00346513671257753 A101 -S157 -0.00388309194534298 W220 -N266 -0.00445626882921157 F160 -W220 -0.00528662671305913 I103 -I225 -0.00640899159033559 S153 -F164 -0.00671654681880862 C219 -I254 -0.00697317610881254 I171 -S211 -0.00703352396949475 A168 -I225 -0.00704733035049321 I93 -S98 -0.00739914060091706 T90 -L170 -0.00744486350540363 P167 -I225 -0.00776696617517669 P222 -S255 -0.0100870118400191 L221 -F258 -0.0106670680529293 V213 -A264 -0.0111449807963613 R227 -I254 -0.011560236852632 V210 -V272 -0.0116833387371105 F163 -L170 -0.0118376994469385 Q226 -S263 -0.012183360155865 M89 -I97 -0.0125379663355538 S211 -I268 -0.0132535325564014 M165 -M174 -0.01332610618927 V210 -I268 -0.0134611945204774 W95 -I105 -0.0136569599751306 F164 -F232 -0.0141570319856461 P104 -I155 -0.0143978539079629 F232 -G256 -0.0150722993942711 M94 -S99 -0.0155777560488497 I156 -F223 -0.0164858755418127 F164 -L218 -0.0167192924469397 P167 -F216 -0.0171978961294665 F163 -V231 -0.0173228687791709 S98 -W220 -0.0177224912782719 A159 -I169 -0.0181307960349653 S99 -I108 -0.0181396721841258 P104 -A159 -0.018151138670246 S99 -F160 -0.018192614093225 V213 -P267 -0.0183141011391577 S157 -I166 -0.0201237947848112 W95 -F107 -0.0219963448089908 T172 -S211 -0.0220432422848984 S98 -H154 -0.022176530950069 T90 -S98 -0.0227230757663528 I161 -H224 -0.0227857654144963 W220 -Y259 -0.0228294309753778 F216 -H224 -0.0234420472584764 F223 -S261 -0.0237555461719241 Q226 -Y259 -0.023856576250302 W220 -A264 -0.0242328767139997 I166 -R227 -0.0261041166578218 I214 -Y270 -0.0264589881283119 F217 -I265 -0.0265096962399118 W220 -R227 -0.0273010990952032 V212 -A264 -0.0274581003459119 F216 -Q226 -0.0279804034093822 F216 -Y259 -0.028449276952383 L170 -I214 -0.0289409242222334 C257 -N262 -0.0291395744451584 I171 -F217 -0.0300860525693931 A101 -I155 -0.0303986482091201 T172 -F217 -0.0313668975994326 I93 -A162 -0.0316941150043544 I93 -A102 -0.0320885044803116 F216 -N266 -0.0322714642336401 L209 -F217 -0.0325171954873946 I103 -S157 -0.0330213452244775 I103 -S153 -0.0339440115170992 W220 -I254 -0.035127367280996 L228 -Y259 -0.0354038078143333 P222 -Y259 -0.0355284115342603 I161 -P167 -0.0362090950823921 F158 -R227 -0.0363033243488089 F160 -F217 -0.0394800778051767 I156 -A162 -0.0395313477513071 P167 -I214 -0.0397132562456601 L228 -Y260 -0.0399783230902546 S98 -I155 -0.0399839658426333 S98 -I225 -0.040015463222776 H154 -F163 -0.0404287285251059 V231 -S255 -0.0406395681075846 I97 -Q226 -0.0418040885580302 M174 -V213 -0.0425024067758009 I97 -F164 -0.0426644233968929 A159 -L228 -0.0436383930832065 C219 -I268 -0.0439802946858396 I161 -I225 -0.0445189545935039 S99 -I155 -0.0449147378214096 W95 -P167 -0.0458371881348081 L218 -F258 -0.0461997459422649 S215 -W220 -0.0464439781613679 F258 -S263 -0.0474848378038528 R227 -S255 -0.0477213499988725 S215 -I268 -0.0478442503816865 M165 -L221 -0.0488333660297693 V210 -L218 -0.0495450440471981 I97 -M165 -0.0499557264529341 V210 -F217 -0.050214451274802 M94 -I103 -0.051260604021593 M165 -I225 -0.0520015014905342 S261 -I268 -0.0521793222584019 L170 -V213 -0.0525958780358975 S99 -F107 -0.0527224199348281 V210 -N266 -0.052754920766545 I96 -A162 -0.0546123172954252 S157 -H224 -0.055144998559602 I166 -M174 -0.0551862171065032 A101 -I166 -0.0554255774806114 W220 -C257 -0.0558114078763783 F216 -N262 -0.0558117458968188 S98 -F107 -0.0564735813554917 F217 -N266 -0.0582716790477704 S99 -V109 -0.0596469989985264 P222 -Y260 -0.0596980588067777 F160 -L229 -0.0597351510028945 M94 -A162 -0.0598851388555073 F163 -I171 -0.0601092462841886 L173 -L209 -0.0605657474411885 I225 -F258 -0.0636491012136591 L209 -I265 -0.0637165729890405 S99 -I225 -0.0637171241854038 L218 -Y260 -0.0637726134620733 H154 -F160 -0.0638463426270981 L209 -Y270 -0.0645258413713266 F217 -A264 -0.0650508639365608 I96 -F164 -0.0661348604753915 L228 -Y253 -0.0661359274020272 V210 -P267 -0.0662708413384252 F258 -I265 -0.0662737357510759 W95 -A162 -0.0663255373183975 L218 -N266 -0.0669859361220633 L228 -I254 -0.0683262414242822 V212 -S261 -0.0683359584123808 S157 -R227 -0.068497343346677 M165 -L173 -0.0685776765340314 F160 -F232 -0.0686224976712557 I100 -F160 -0.068913364020863 I156 -V231 -0.0693409056053458 F164 -S230 -0.0699120886606175 M165 -V213 -0.0706719273478713 I103 -F158 -0.0714366271384668 T90 -P167 -0.071944850116938 R227 -F258 -0.0723944003123661 S153 -F160 -0.0731587332229202 W220 -Y253 -0.0732479315386687 Y253 -Y260 -0.0733825284852418 S98 -A162 -0.0734525147792819 V213 -P222 -0.073648622099308 I214 -I268 -0.0738123305749232 A102 -H154 -0.0739366287150567 I97 -F158 -0.0742191095355409 P167 -L209 -0.0742271731647257 P167 -V210 -0.0751029436095124 F232 -S255 -0.0751544784485394 F217 -S230 -0.0753487409532173 I214 -F223 -0.0753587697440474 P167 -V212 -0.0753966353884836 L173 -V213 -0.0754712068485492 W95 -I108 -0.0761167744288676 F160 -S230 -0.0768068253072487 A159 -F232 -0.0768472082178935 I161 -L221 -0.0773617278620362 F160 -I169 -0.0774086687731996 I214 -L269 -0.0776889064508697 W220 -S261 -0.0777497765406145 L218 -L229 -0.0784026010729235 S211 -W220 -0.0787994721635696 S99 -F164 -0.0791410496899251 W95 -P104 -0.0794456801775341 F164 -L221 -0.0798790277139858 L221 -Y259 -0.0802981287364117 S211 -F217 -0.0804556758334045 F158 -S230 -0.0804716429429718 I96 -F158 -0.0804984863118094 T172 -V212 -0.0806064937155339 I103 -F160 -0.0807046878151436 S215 -I225 -0.0812856892779803 R227 -Y259 -0.0822255637578204 I171 -Q226 -0.0829607783775241 A159 -M165 -0.0837184633171715 L221 -S230 -0.0839539507262099 I100 -F164 -0.0845356479637012 M165 -P222 -0.0851457455003963 I225 -S255 -0.0853147870772872 S98 -I161 -0.0857928978362617 F217 -L229 -0.0857978283306347 F158 -I166 -0.0862654304360984 P167 -W220 -0.086763118187744 I96 -A159 -0.0869130014047981 V213 -N262 -0.0872858018811846 I214 -S263 -0.0874934077628098 A102 -S157 -0.0882576569562223 A102 -Q226 -0.0882838357591331 I155 -F232 -0.0885791413625459 F158 -I225 -0.0887011874933599 Y259 -A264 -0.0887390422029751 I155 -I225 -0.0889229854484768 F216 -S263 -0.0889537880214579 F223 -I254 -0.0903284314421202 V213 -N266 -0.0906144636894313 F232 -I254 -0.0925312360918342 G256 -N262 -0.0925935652992167 I214 -P267 -0.0927735017299995 L218 -I265 -0.0932876951035216 A101 -F164 -0.0938388681537665 I166 -I171 -0.094139106792567 F163 -L228 -0.0954517574334379 I225 -Y260 -0.0958159426377168 I103 -F163 -0.0958344779358495 M174 -V212 -0.0961470896916721 I97 -I103 -0.0971857606223736 F160 -Q226 -0.0980833025050867 S157 -M165 -0.0982860379278748 I265 -Y270 -0.0990005677902936 F216 -F223 -0.0991981375012028 F217 -R227 -0.099260903439562 A168 -V213 -0.0992645231825557 F164 -L173 -0.0993005198249506 W220 -S263 -0.0993096563691706 F217 -H224 -0.0993629839883163 F217 -L269 -0.0994573348929451 S98 -I108 -0.0995912984993348 I225 -F232 -0.0995939822365792 I166 -F217 -0.0998399468820574 R227 -Y260 -0.099935033876255 A159 -H224 -0.100018852094317 A102 -F160 -0.100251562698453 S99 -F163 -0.100368115691202 I171 -I214 -0.100468176616969 S157 -F164 -0.100568271579088 F216 -P222 -0.101067721236677 H224 -N262 -0.101167118040508 L221 -F232 -0.102419565036165 I161 -S230 -0.102658558887581 A102 -F107 -0.103157853458729 F164 -F217 -0.103215665716705 T90 -L209 -0.103650583182125 L173 -I214 -0.104198814097541 C219 -G256 -0.105011433602207 F160 -A168 -0.105722790989738 F216 -Y270 -0.107454003261052 F163 -R227 -0.107504549569218 P167 -L173 -0.108265783047687 M94 -I166 -0.108571532651307 S215 -R227 -0.108677387062892 I100 -F107 -0.109062271840593 V212 -V272 -0.109283348134716 L218 -C257 -0.10945744275274 L218 -I225 -0.110335484368426 S215 -N266 -0.111863702929201 L209 -P267 -0.112140017614162 G256 -I265 -0.112808919655478 L209 -N271 -0.112834128868592 F160 -L170 -0.113396712473968 A102 -H224 -0.114106226009976 F216 -Y260 -0.114257063710483 I91 -I100 -0.114889577783154 M165 -H224 -0.11537965776355 A159 -W220 -0.116229520634348 I156 -F163 -0.116747636927 I171 -W220 -0.11858933688909 S215 -S263 -0.118608494319124 F164 -L228 -0.119062870195108 V213 -I268 -0.119170958854971 F163 -H224 -0.119896212112806 I169 -V210 -0.119904985890892 F216 -L269 -0.120502192351279 F217 -N262 -0.122034057037284 L170 -F216 -0.122965566387913 A159 -V231 -0.123376893828675 I169 -F216 -0.123509383356414 F223 -F258 -0.125015291026715 T172 -V210 -0.125104637243541 S230 -G256 -0.125191340091553 F164 -F216 -0.125240797062275 A168 -S211 -0.125556206140057 W220 -V231 -0.125889285491754 L170 -F217 -0.126041194362945 W95 -A101 -0.127796684294929 I214 -N262 -0.129476753627945 T172 -L209 -0.129940877589653 F160 -L228 -0.130298033320317 W220 -L229 -0.131017491670281 A168 -F216 -0.131716961024599 I166 -V213 -0.13184182828447 F164 -I214 -0.134168781353682 I161 -V231 -0.134604151762908 I225 -N262 -0.134705344089377 L229 -C257 -0.136305833204823 F160 -F223 -0.136550096827857 I169 -Q226 -0.136577138028942 P167 -M174 -0.136638973156278 A159 -L229 -0.136653660039263 L218 -N262 -0.136941224063066 L209 -N266 -0.137166219888913 I93 -I103 -0.137563874997312 Q226 -I254 -0.141618262910509 L229 -I254 -0.143176511052685 A87 -I96 -0.144400100342175 C219 -I265 -0.144820726731812 H154 -A162 -0.144986897313735 I96 -I166 -0.145373915460894 I93 -I100 -0.146317860716684 S98 -P167 -0.146342840714887 L228 -C257 -0.147552040348804 F217 -V231 -0.148452621970219 I97 -I169 -0.148801576211036 I169 -M174 -0.149430031843441 L170 -L209 -0.149778832342432 F164 -I171 -0.150076411103236 P222 -F258 -0.150696516335208 I92 -S99 -0.150729440657897 L229 -F258 -0.151862752006806 F164 -L170 -0.152797000741657 F217 -I225 -0.153366838142929 I155 -I166 -0.15400103557457 I97 -L170 -0.154357006202014 A102 -I156 -0.154459745627491 A102 -I161 -0.155203468293659 C219 -N266 -0.155249556244916 I96 -I105 -0.155281206084166 I93 -I166 -0.155753130907955 F223 -S263 -0.155880107066831 I161 -I171 -0.156945573667308 Y259 -I265 -0.156950739071048 I225 -Y259 -0.157076398792961 F164 -P222 -0.157172254580473 F217 -Y259 -0.157223469392747 I156 -S230 -0.157279520043745 A102 -F163 -0.157444603852838 A101 -I161 -0.157555238551273 M89 -I96 -0.158686414525786 I161 -L170 -0.159097547306513 Q226 -N262 -0.160437928939124 V231 -G256 -0.161329916915101 A102 -A159 -0.161385123439286 F217 -Y260 -0.161578178865848 F160 -P167 -0.161700393738055 I91 -S98 -0.162060469871737 F217 -S263 -0.163330707669073 F223 -V231 -0.163674641706415 A168 -L209 -0.16381651937423 F160 -L221 -0.164123932438243 I155 -Q226 -0.16514457353516 P222 -I254 -0.16546070355926 S263 -I268 -0.167104317841875 S261 -P267 -0.168633839704266 I161 -Q226 -0.16876681845152 W95 -A102 -0.168986340939283 I100 -I161 -0.169438019019752 F223 -F232 -0.17021318610194 A264 -L269 -0.170298754467106 F158 -P167 -0.171411048192249 F216 -P267 -0.171665886216754 I161 -I169 -0.171932526523229 P222 -Y253 -0.172381690231436 F232 -Y253 -0.172665076801497 A159 -Q226 -0.173679097789011 I254 -S261 -0.175502843502152 S215 -Y260 -0.175807843619417 L209 -F216 -0.176814569345225 I225 -V231 -0.177116379958893 F217 -L228 -0.177941889347101 L218 -S230 -0.177968294087923 Y88 -M94 -0.178246004422273 I97 -P167 -0.178321022893082 S98 -P104 -0.178495626760869 S215 -I265 -0.179540627733603 I265 -V272 -0.179677630354903 A102 -F158 -0.180855384012504 F216 -F258 -0.18151426866963 F216 -S261 -0.182850414866035 L218 -R227 -0.18390516169946 F163 -W220 -0.184051854941262 F163 -I169 -0.184174697499759 I225 -Y253 -0.186531977293506 L209 -S263 -0.187081755193639 Y253 -F258 -0.188135481065053 F158 -H224 -0.18838989957206 V212 -I268 -0.189494699133898 L229 -S261 -0.190229986416873 P222 -S261 -0.190468596529357 F164 -H224 -0.190699583084077 S98 -F164 -0.190817907946026 I169 -V213 -0.190915127985926 S98 -A159 -0.191237784529995 I155 -I161 -0.194213707123246 I265 -N271 -0.194222519004894 Y260 -I265 -0.194318719285632 T90 -W95 -0.196647986578311 M94 -F163 -0.197152340651185 Y88 -I96 -0.197944847184146 I225 -G256 -0.1992734795538 V212 -I265 -0.200348743702008 P222 -F232 -0.201748136413705 I254 -Y260 -0.202343564267262 A162 -I169 -0.202357017362651 F163 -F216 -0.202397551468108 W220 -L228 -0.202685173563541 Q226 -F232 -0.204357761852918 Q226 -Y260 -0.20468216411026 R227 -G256 -0.205918209680416 L173 -V210 -0.207082799381484 F164 -I169 -0.208264102692612 I92 -I97 -0.208906370680756 L218 -S263 -0.208991612898342 H224 -Y253 -0.212850846944481 V212 -P267 -0.214258039667264 I156 -M165 -0.214678384463053 I156 -F164 -0.2161590169452 T90 -I96 -0.217014189524743 S211 -L269 -0.217521263103242 V212 -L218 -0.218005673817317 I92 -I100 -0.220617572733209 M174 -I214 -0.220688577197025 I161 -R227 -0.220813619229052 L218 -Y259 -0.221039950211826 I103 -I108 -0.221212071159581 F216 -I265 -0.221639111968065 C219 -Q226 -0.221980385343509 C219 -I225 -0.222038926211721 I155 -F164 -0.222242729316706 M165 -F217 -0.226604897126482 I93 -S99 -0.227629363633215 W220 -F258 -0.227786896749858 A87 -M94 -0.229205392856801 Q226 -G256 -0.233221220160249 A162 -A168 -0.233572210488699 L218 -Q226 -0.233780322191748 V213 -W220 -0.23425548526556 L218 -G256 -0.23771985391746 T172 -I214 -0.240051983582342 T90 -I97 -0.240127117703137 G256 -S261 -0.240596824807492 M165 -T172 -0.243555243655841 M165 -R227 -0.246130434137799 M94 -I100 -0.246254733036293 L209 -S215 -0.246350627319901 V212 -S263 -0.25047458221669 A159 -R227 -0.251368401457531 S99 -I105 -0.257348578984332 I166 -L173 -0.257762278897046 A101 -I225 -0.260069556087108 P267 -V272 -0.260195169343901 I171 -L209 -0.261485796162818 A101 -F160 -0.263097909477467 F223 -S255 -0.263950074408321 S98 -F163 -0.267405473317257 S211 -F216 -0.269486486596903 W220 -S230 -0.272316514468375 A168 -F217 -0.272324110273673 F158 -M165 -0.273365256970297 N266 -V272 -0.274010798723463 I92 -S98 -0.276874494220245 I91 -I96 -0.278130162351738 H224 -F258 -0.279064884093076 C219 -P267 -0.282849275974166 M174 -V210 -0.289414848301438 I166 -T172 -0.289595014500881 V212 -Y270 -0.29771118970895 V212 -C219 -0.298050531787545 I156 -R227 -0.301610366202574 F163 -A168 -0.302442387997729 F164 -W220 -0.30958802730924 C219 -H224 -0.310920074155312 A159 -I166 -0.3131849350302 S211 -Y270 -0.314579829461243 I214 -L221 -0.31739509255891 M89 -M94 -0.318612618076306 F160 -H224 -0.321331858739228 I155 -A162 -0.321498176701532 L221 -V231 -0.325522341793832 S215 -L221 -0.326069166948202 F163 -Q226 -0.327171554419619 F160 -V231 -0.328444529317255 V212 -F217 -0.330623166944037 W95 -I103 -0.333288338546658 I100 -F163 -0.33430149527641 M165 -Q226 -0.335015263298908 S153 -A159 -0.335023076404941 A87 -I93 -0.335595903832856 F160 -I166 -0.33613517659903 N262 -P267 -0.336414033518356 I161 -A168 -0.343505481781462 C219 -L228 -0.344754938235466 N266 -N271 -0.349781149695008 I214 -W220 -0.350128079601813 L221 -G256 -0.352506183044513 L218 -L228 -0.356568600128863 V210 -F216 -0.358288496805108 I91 -I97 -0.361517238603388 M165 -I171 -0.382819511354275 A101 -H154 -0.38552568584119 H224 -Y260 -0.38975037043718 I155 -R227 -0.392180301908001 L228 -G256 -0.395599711397054 I97 -A102 -0.40246789857407 M165 -L170 -0.402844816961408 L209 -L269 -0.411141929720472 A168 -M174 -0.411681883027915 M89 -W95 -0.423853278057737 H154 -Q226 -0.433417577926739 S230 -C257 -0.44503901115389 I225 -C257 -0.451209726207727 I96 -A101 -0.45897440269941 V213 -C219 -0.469157450649631 I155 -V231 -0.486095064838546 R227 -C257 -0.500448610941746 H224 -I254 -0.502565120348972 C219 -C257 -0.511652285060144 I155 -H224 -0.512571594165246 H154 -I161 -0.516026424933643 I214 -C219 -0.541381755351635 L221 -C257 -0.545366026505609 P222 -R227 -0.609800625000157 P222 -G256 -0.611061738193346 C219 -R227 -0.624828878565642 C219 -F258 -0.782395799270538