[Mon Aug 29 17:19:44 2016] >Input file: TMB2HHL2M3G.pdb >TM segments: 110-135_ 214-239_ 241-290_ 440-456_ 546-573 MAIDEN score = -32.6326 Below is the ranking list of the residue pairs and their related pseudo-energy (the lower, the better). This includes inter-chain residue pairs. The maximum (least favorable) pairwise energy value has been set to 10. See the MAIDEN software article: Postic,G., Ghouzam,Y. and Gelly,J.C. (2015) Biochimie, 115, 155–161. ----------- ---------------- Calpha pair Empirical energy ----------- ---------------- V228 -F252 0.957974240333046 W547 -A568 0.826804393462986 L218 -T262 0.741483281002015 V239 -E248 0.719730577933163 L218 -A266 0.672761828742967 D267 -L272 0.629792239064848 H214 -T262 0.595743272161944 I236 -R244 0.580388594666826 E215 -A263 0.545402190347202 V239 -R244 0.503874243173016 H214 -A265 0.475699709111278 V238 -R244 0.458605659387084 V546 -R551 0.45433179087629 S563 -A569 0.444390210101113 T561 -E571 0.44391100885464 C242 -R249 0.419292558571885 C554 -V559 0.419133168358132 M225 -S256 0.415911929446636 R224 -V229 0.402230813206831 V228 -V255 0.383085519004348 Q219 -Y259 0.3507951384792 L218 -D223 0.349657231071641 L221 -V255 0.348376056674132 Q270 -P275 0.346069089044151 H214 -Q270 0.340964072129102 G132 -E442 0.338420042525549 L221 -T262 0.338044364455626 R224 -V255 0.336189594421228 P555 -E571 0.336177639755745 D223 -R230 0.332614225686536 M225 -Y259 0.330929887641779 R230 -I236 0.3291191953709 K220 -A257 0.32282266718074 S563 -A568 0.316827158492481 G111 -G119 0.312811127806978 Q254 -Y259 0.312479764771098 L218 -R261 0.311781473520871 H214 -Q219 0.309217047600529 K220 -Y259 0.308985641569961 S446 -A557 0.303396373937305 K220 -M225 0.302866213283838 T561 -A569 0.301295180387564 G217 -S260 0.293764373115097 R268 -L273 0.292628465167487 A558 -A572 0.291415464593369 R251 -Y259 0.290076943765457 D223 -Y259 0.28627268909374 M225 -V255 0.285771122687481 L218 -Y259 0.282262226173497 S446 -A558 0.279405700857067 A448 -A557 0.276506456246925 N226 -E248 0.27555838923785 R216 -L221 0.27288734287168 G217 -L264 0.272695053413476 W269 -A274 0.266347213012526 G235 -E245 0.265906905964898 Q232 -V239 0.257242489180067 R224 -A257 0.252535963429922 Q232 -G250 0.251307485890383 V449 -C554 0.249251480871577 M225 -R261 0.248148957087801 R129 -M135 0.247600653551797 V229 -F252 0.244382345679044 M116 -R124 0.240801752473393 N226 -R251 0.238488187042394 T131 -E442 0.229413692482534 Q227 -G235 0.226162845269159 G217 -T262 0.225830229373084 R551 -A558 0.225040106710896 E125 -V130 0.220741997314211 Q232 -F247 0.219940430056948 L550 -T561 0.216729787967893 A277 -S284 0.2164878294037 N226 -G253 0.21579407475563 V229 -Y259 0.214093205594118 Q219 -A263 0.213258331360733 R249 -A257 0.213003542172554 Q219 -S256 0.210956127366734 M225 -R249 0.20787236985637 V228 -I236 0.207216895976669 Q232 -Q254 0.206340399341594 W547 -P555 0.205178610114865 R224 -R249 0.204494934218331 A121 -D128 0.204395911954706 V562 -D573 0.203134914386029 H214 -S260 0.200911816402265 N226 -Q232 0.196121956232914 A552 -E571 0.191815826174986 L221 -S258 0.191180741279028 S446 -S553 0.190515751455234 V228 -R251 0.190390747750641 T131 -P441 0.187265387217226 R216 -A265 0.186698372337152 Q219 -Q270 0.186490019093982 L218 -A263 0.184124170215877 W547 -T561 0.177397600947507 D267 -P275 0.177301840038523 V566 -D573 0.176982157761336 E245 -G253 0.174989298164861 L233 -V239 0.173186522908904 E245 -R251 0.171173134623386 E215 -A266 0.170847885706956 P451 -L456 0.169517844705993 R216 -R268 0.16832819146143 R224 -S260 0.167584600441896 Q219 -R224 0.167249644082594 M225 -S234 0.164324515483047 V229 -G253 0.162833221786909 D223 -T262 0.161201384577205 E231 -V239 0.161093948610489 T561 -G567 0.160750797299181 G253 -A263 0.160702336168387 A448 -G453 0.160235055158248 R230 -E245 0.159707177141087 G235 -E248 0.155578028506172 R551 -A569 0.153745525698254 S112 -R120 0.151396030328272 P451 -Q564 0.150267946284385 V450 -V546 0.148940753465376 E442 -A448 0.147362784050988 R551 -A570 0.146838771218787 R216 -Q270 0.146407889233802 Q232 -G253 0.144553019766663 S134 -E442 0.144190331983789 Q452 -R565 0.144042245205157 W547 -R565 0.143389471739001 F222 -Q254 0.142082138204483 D128 -M135 0.141001691759705 T262 -Q270 0.140012704320236 L218 -N226 0.139512475081443 V449 -I560 0.137011386785643 H214 -S258 0.13652948996785 A241 -E248 0.135557561712145 R124 -G132 0.135529591843467 Q227 -R249 0.135294444835223 M225 -F252 0.132739666580471 A548 -A570 0.132684504442559 E231 -R244 0.129414888946187 I560 -A570 0.128571232298338 E215 -A265 0.128402263668424 M116 -R123 0.125863111691825 A548 -A572 0.124024145702228 Q232 -G246 0.123672533052036 R565 -A572 0.123042111716164 N226 -A257 0.121774188687063 E248 -V255 0.12081003404095 W547 -G567 0.120164727782123 G235 -Y455 0.11998434343565 W547 -A570 0.11946834609657 V228 -A257 0.119210721827214 H214 -A271 0.11817094873139 A448 -S553 0.117973035545003 A243 -E248 0.117548666144596 S282 -V289 0.117525051351101 R216 -D223 0.116943001934122 S563 -A572 0.116289246823971 Q219 -N226 0.116281428548994 L218 -Q270 0.116124488546198 A243 -G250 0.115871052112057 F247 -Q254 0.115447630889408 S284 -V289 0.115106236789451 E215 -S258 0.114519732432585 A552 -A558 0.114110360154401 L218 -S256 0.113460529390578 M225 -E231 0.113166278041806 L264 -A274 0.112369062292482 M135 -Y455 0.111837681369751 A557 -A572 0.110575230343148 G453 -V562 0.109990531236864 D223 -R261 0.108402761985023 A549 -A557 0.107998011991072 A121 -R129 0.107498085907107 R224 -Y259 0.107026440840148 A448 -G454 0.106228111745504 R261 -R268 0.10530304013533 E231 -V238 0.105188713979744 K220 -R261 0.104089066465511 G235 -G246 0.10395710833577 R237 -E245 0.10317814630256 P555 -A570 0.101752231511131 R237 -R249 0.10155787426296 R230 -G235 0.101375987819578 D223 -E231 0.101338670978865 T561 -A570 0.101287629179056 R237 -R244 0.100745379742768 R249 -Q254 0.100140793558903 S234 -E245 0.0999440955186488 L272 -V280 0.0992247950465788 A552 -A572 0.0980043649581264 A266 -P275 0.0978860104116719 S260 -R268 0.0971748477034859 D223 -S260 0.0968615013348566 M135 -P441 0.0962622641112385 R224 -A263 0.0960447040871184 R551 -E571 0.0959425274289236 G250 -V255 0.0955294665581228 V280 -L288 0.0954633845942885 E215 -D223 0.0954570634803518 V546 -V559 0.09532760269098 S446 -C554 0.0947270341473426 A548 -V559 0.0946670587512441 R551 -T561 0.0943413473244905 I560 -A572 0.0941172090201219 W269 -A277 0.0931402442015221 M225 -G250 0.0931263678956791 C554 -D573 0.0926797043159516 V238 -G246 0.0920072375289283 H214 -Y259 0.0918981399350574 R237 -E248 0.0912568313117355 R261 -W269 0.0912198813783607 L279 -V286 0.0909410631246792 L444 -V449 0.0905419236254685 A121 -V130 0.0904621503303402 R224 -R230 0.089207880796248 L264 -L272 0.0883124136435742 S256 -L264 0.0882544067515392 Q270 -L279 0.0866338329801808 M225 -T262 0.0865034635242035 L233 -R251 0.0859847238670471 V238 -E248 0.0859405500192594 L221 -N226 0.0855767965937044 V450 -A558 0.0843824039258361 G235 -R249 0.0843507647864538 A557 -D573 0.0840416975761542 A548 -A569 0.0829561540529928 V276 -L283 0.0826385566838801 V449 -L550 0.0825887872730526 F222 -Y259 0.0823147603162759 S553 -T561 0.0822882620627902 S234 -A241 0.0819905162167984 T278 -S285 0.0818787893851951 G235 -A243 0.0818175111586936 R565 -E571 0.0815239557062446 G217 -Q270 0.0810885526211211 L218 -A257 0.0808501146073217 L233 -R244 0.0800184468090454 C554 -A572 0.0795044254753925 R216 -L264 0.079268146014926 S234 -C242 0.078560460633945 M225 -A263 0.0782086318042859 R224 -T262 0.078031837755297 G117 -E125 0.0775250514830645 A552 -I560 0.0769594503225828 V276 -S284 0.0767593880062587 L279 -L288 0.0767518478466682 R445 -V450 0.0765046692858911 K220 -A265 0.0761567280260156 V450 -S563 0.075364518638136 R251 -S258 0.0747882506073644 R244 -R251 0.0743027237076699 E215 -L221 0.074189290904578 E231 -R251 0.0735070604118571 A271 -V280 0.0722476509835035 G132 -P441 0.0707796030824905 R120 -R129 0.0698368385808732 C554 -A569 0.0696542570094545 R123 -T131 0.0683437629975785 E231 -I236 0.0679509624047494 E215 -Y259 0.0679475326388743 R261 -Q270 0.0678122516723987 W547 -S563 0.0677448645449129 G453 -T561 0.0676083282801443 H214 -A274 0.0672301149790799 H214 -W269 0.0659865405057848 Q452 -I560 0.0657726830279994 Q219 -A265 0.0654347472641024 W133 -P441 0.0651776018601078 R445 -A557 0.0648570083876329 R261 -A271 0.0648411805549722 A549 -A568 0.0645118943225342 F222 -S256 0.0643611848609105 E231 -E245 0.0643324407054059 V228 -L233 0.0641840365069406 A274 -S282 0.0639508367626487 V546 -G567 0.0638647103342862 S553 -E571 0.0633983416099859 G235 -F252 0.061673540687758 I560 -E571 0.061487386137427 N226 -S260 0.0582261086153147 R268 -P275 0.058021995813428 L218 -Q227 0.0577616098581641 K220 -S256 0.0574991252372814 V546 -C554 0.0574266182852066 G111 -F118 0.0572167885515142 Q219 -D267 0.0568685577307459 S446 -V559 0.0564927209568609 V280 -V289 0.0563088190892937 R268 -V276 0.0560515217237143 A241 -R249 0.0556529401748311 L233 -A241 0.0554816305565391 S446 -D556 0.0553925074596571 V239 -R251 0.0545221774180737 E215 -R261 0.0539227469373258 G217 -M225 0.0527209389340655 E125 -G132 0.0525554142901346 V229 -G246 0.0515208191718172 R123 -R129 0.0511754743405171 R224 -Q254 0.0511305162380751 V449 -A557 0.0510477861384029 G246 -V255 0.05097066387604 L218 -Q254 0.0502431882057817 D128 -S134 0.0499102879974074 D223 -S258 0.0497317051024144 A558 -D573 0.0486898369409348 N226 -S258 0.0484083097592811 V228 -V239 0.0479961207543607 W547 -A572 0.0472665112485817 R124 -T131 0.0454620833316439 V228 -S258 0.0447839022569423 V229 -V238 0.0445391184397979 R244 -R249 0.0439658840409827 A552 -A569 0.0435515655096177 S256 -A265 0.0435030347813434 G250 -S258 0.0434851968600105 N226 -S234 0.0423526549194486 S282 -W290 0.0411349170076214 E125 -W133 0.0409091411063471 V546 -A569 0.0406464174703434 I447 -T561 0.0377004288631131 R224 -E231 0.0376773134411112 A448 -L550 0.0376316771643248 F222 -V255 0.037349982296992 R551 -I560 0.0371922662086828 A263 -A271 0.0371717421010067 G246 -Q254 0.0366718661226262 F247 -V255 0.035935914722301 G132 -Q443 0.0357591614301627 K220 -V228 0.0356431176109566 R230 -V255 0.0331294776858352 L221 -Y259 0.0328300531318639 A552 -T561 0.0326965161252526 V228 -V238 0.0325898490001215 Q232 -R237 0.0325682232520692 A548 -T561 0.0321335361196248 V229 -V239 0.0311034772484522 G235 -C242 0.0306875940900597 T278 -V286 0.0303448625561524 I447 -C554 0.0301939342587385 P451 -I560 0.0297792202619782 S234 -E248 0.0294299772543338 L233 -E245 0.0293389949850382 A266 -A274 0.0292686092273051 S134 -D440 0.0292585601927318 G217 -V255 0.0291603727965084 M225 -G235 0.0282698324946971 A549 -T561 0.0280401637712178 M116 -E125 0.0277984089007659 Q232 -V255 0.027384579200203 R124 -R129 0.0268906312306876 A257 -A265 0.0265037957815011 I560 -A568 0.0256821755944632 G235 -A241 0.0251764462903044 F222 -L264 0.0251019164566526 A548 -G567 0.024861730952574 Q227 -Y259 0.0247503867550858 G217 -A257 0.0246761348008255 Q227 -S258 0.0245652809523751 M135 -P451 0.0225919772991767 Y259 -D267 0.0217185615653754 R230 -F252 0.0214621236278965 L233 -V255 0.0206818224868763 V229 -R237 0.0199383379825941 W547 -V559 0.019914893565514 A549 -D556 0.0197512854457011 R129 -S134 0.0193288468960877 V229 -G250 0.0188790531893956 L221 -S256 0.0184982526187873 V559 -A569 0.0180195497903202 L233 -G250 0.0179726883366551 E231 -V255 0.0177291698257972 Q254 -T262 0.017600915642876 L233 -R249 0.0175057584465019 L221 -G253 0.0174860166791664 V229 -E245 0.0169883850619913 V239 -G250 0.0161215056848132 S258 -A266 0.0159719481270346 L126 -W133 0.0158142465120399 K220 -A266 0.0154452114376635 A243 -F252 0.0150349473725369 V559 -E571 0.0149737987814676 A263 -Q270 0.0146861749614438 P451 -T561 0.0140950922794145 C554 -A568 0.0140711605172119 H214 -L272 0.0140101508116022 M225 -G253 0.0129811222878633 R551 -D573 0.0129560915612594 A241 -F247 0.0129018377628154 A548 -A557 0.0127586305496719 V238 -E245 0.0124499567218361 P451 -S563 0.0124350743473673 I560 -R565 0.0116759155571327 L233 -G253 0.0116662473265099 V238 -A243 0.0115248342637102 F222 -R230 0.0114929925600133 S553 -I560 0.0111422949494751 C554 -V562 0.0111369579258103 Q232 -S256 0.010478292178401 G235 -R244 0.00999617208832548 G253 -R261 0.00993673685626467 I447 -V559 0.00978238996134628 W133 -E442 0.00951094264662089 H214 -L273 0.00933848088888811 S258 -D267 0.00915132591204054 D223 -V228 0.00854267149597199 V228 -Y259 0.00843580546903588 S563 -D573 0.00836779454032566 F222 -A265 0.00792838850674027 Q564 -A570 0.00763385086834312 V229 -S234 0.00715286820038363 Q227 -Q254 0.00673422060380968 Q219 -V255 0.00644466754249295 V228 -S256 0.00641655888577386 C554 -A570 0.00612351163257774 E231 -G250 0.00525523515358817 Q270 -T278 0.00522816828499639 R230 -V239 0.00414502007463646 L444 -V450 0.0040400759258965 V562 -A572 0.00398779131302085 K220 -S260 0.00383727119917721 V239 -G246 0.00357812915767042 R249 -Y259 0.00295256941138566 L264 -L273 0.00271449955588388 G119 -R124 0.00268418824826844 I236 -G246 0.00263572896120889 R261 -A266 0.00246481612470784 S115 -R123 0.00211502631260618 L233 -F247 0.00175083086070948 E231 -F252 0.0014315807688785 G132 -L444 0.000506022757186475 V229 -Q254 0.000290332664891313 P275 -L283 -0.000612981878283847 S134 -L444 -0.000855465510582659 L233 -S256 -0.000920129326154484 S234 -Y455 -0.00272930252877579 F127 -S134 -0.0031564091529015 R244 -F252 -0.00366914144473518 L550 -A570 -0.00450801782907817 P555 -I560 -0.00496598350824873 V559 -A570 -0.00529284329046797 V238 -F247 -0.00572349062643918 A265 -Q270 -0.00576700426038634 V450 -C554 -0.00588571506913382 N226 -R249 -0.00635103807473225 T262 -A271 -0.00655074686640811 V450 -A549 -0.00677848988995322 G235 -R251 -0.00696078646701093 R120 -E125 -0.0071138652917373 G453 -S563 -0.00754162983461359 C554 -T561 -0.00762569502561661 A549 -V559 -0.00769788593005094 L218 -V255 -0.00770350463920622 A552 -V559 -0.00802687077552067 I281 -W290 -0.00836627305084958 V449 -V562 -0.00846845069480784 V255 -A263 -0.00908244491081422 W269 -L279 -0.00915013878728477 R224 -G253 -0.00922296322461524 D440 -S446 -0.00930757872362564 Q232 -R244 -0.010202120556206 A549 -A569 -0.0102095409974527 E231 -S256 -0.0103157412134435 A263 -R268 -0.0115306602385691 V229 -A257 -0.0128272715747531 P555 -A569 -0.0129679096030859 V239 -F252 -0.0133523883914881 E215 -R268 -0.0133651852132832 G217 -S256 -0.0134550957381316 V562 -E571 -0.0136502810322123 R237 -C242 -0.013958951301334 A448 -C554 -0.0151850290542981 E231 -R237 -0.0152897173372674 Q270 -A277 -0.0154264787582159 A558 -A569 -0.0164810986234167 Q564 -A572 -0.0165069121926584 R224 -G250 -0.016598911291605 D223 -A263 -0.0183056415278107 S256 -R261 -0.0183344479493246 R230 -R249 -0.0183504643643666 L279 -S285 -0.0186096046705622 V450 -Q564 -0.0190209840445399 V228 -S260 -0.0193815278899054 V450 -V559 -0.0196241628227414 I236 -F252 -0.0197963587200336 S115 -R120 -0.0205529355753993 H214 -D267 -0.0205772257605608 Q564 -E571 -0.0208415510193157 T561 -D573 -0.0208687294089316 I236 -R249 -0.0212386373326474 F252 -S260 -0.0213369748266796 S260 -W269 -0.0221383399445658 L221 -R261 -0.0221407128442781 G217 -D223 -0.0224537236937685 R251 -S256 -0.0225944993937763 A241 -G246 -0.0232976781513083 V562 -A570 -0.0233240821522427 L272 -I281 -0.0236703338989486 P555 -D573 -0.0237870565906695 N226 -Q254 -0.0238812882639339 P441 -A448 -0.0243162105067244 V449 -A558 -0.0252860463512478 L550 -G567 -0.0253702240249725 G453 -Q564 -0.0255575197453275 H214 -F222 -0.0260142782467208 G119 -D128 -0.0266205872324516 V559 -A568 -0.0266286363766207 Y259 -A266 -0.0274296193764467 Q254 -A263 -0.0282292341784931 R230 -G253 -0.0286435044249149 L233 -E248 -0.0287194758875771 G217 -D267 -0.0292024975897207 V449 -Y455 -0.0294072199531383 F222 -T262 -0.0298461908187584 A448 -V562 -0.0299666000769547 V255 -S260 -0.0302909463105321 A568 -D573 -0.0306052524493965 E245 -Q254 -0.0319041270656076 Q227 -E248 -0.0320979772028781 T262 -R268 -0.0331231880819291 V546 -T561 -0.0336170874710278 V228 -R249 -0.0339490275061607 P451 -V559 -0.0339525961990685 R216 -T262 -0.0340039052571343 S260 -D267 -0.0341340051931422 D223 -G253 -0.0342237899841027 D223 -S256 -0.0342535932311994 Y259 -R268 -0.0355036077612882 D556 -T561 -0.0359597092620989 Q254 -S260 -0.0362024537583918 L550 -D556 -0.0362936748308765 Q219 -V228 -0.0366222834124783 T278 -A287 -0.0366670561240159 R551 -G567 -0.0367335867785119 A243 -R249 -0.037181357866837 L221 -A257 -0.0376364596825274 E215 -R224 -0.0376945102207706 L233 -G246 -0.0383397392583964 G117 -R123 -0.0384395132721806 T262 -W269 -0.0392625679750704 I236 -R251 -0.0401068384056131 Q232 -A243 -0.0405835103276599 Q443 -A448 -0.0410204670652932 Q227 -R251 -0.0418353982927031 R230 -R251 -0.0419145084342162 M225 -Q232 -0.0420102349338016 E215 -K220 -0.0423425024934563 S134 -P441 -0.0430030928546081 R216 -R261 -0.043239026499772 E215 -D267 -0.0432974113923543 R445 -A558 -0.0436021403185993 R224 -R261 -0.0438851560888632 G246 -G253 -0.0439464617734497 E231 -G253 -0.0445721589744066 N226 -F252 -0.0448213802431794 Q443 -V449 -0.0451494069757414 V449 -S553 -0.0454120556005591 R216 -D267 -0.0459581336136281 N226 -A263 -0.0462948127477949 G250 -S260 -0.0464120666752042 L279 -S284 -0.0469807922290979 R216 -S260 -0.0469810596995515 G246 -S256 -0.0473856121370529 R249 -S258 -0.0485813947681241 R224 -S256 -0.0487001208800604 G253 -T262 -0.0487773600188453 A257 -A266 -0.0490102393249998 Q254 -R261 -0.0490706858154208 R445 -P451 -0.0491720566442599 I560 -D573 -0.0494857470334629 P275 -S284 -0.0499379772185531 Q219 -A257 -0.0508717854582796 G246 -R251 -0.0509900356966952 E215 -S260 -0.0511220970712463 E215 -W269 -0.0514033901387494 D223 -A257 -0.0520618566631184 M225 -R230 -0.0524468903726039 G132 -D440 -0.052498086051346 V546 -P555 -0.0529226707683073 Q564 -A569 -0.0534990611279118 R230 -R237 -0.0537818358192856 E248 -Q254 -0.0538387204008659 Q232 -A241 -0.0539125711506601 F222 -A266 -0.0541125121505992 G217 -Y259 -0.054947351989667 G119 -F127 -0.0550495770105481 A557 -E571 -0.0553494205644216 R230 -S256 -0.0557637626049302 L122 -T131 -0.0557961089582846 I447 -D556 -0.0561162984870617 L233 -C242 -0.0569194137738176 Q232 -V238 -0.0572020523928289 F222 -G253 -0.0573007245723509 R216 -S258 -0.0575247909703783 I236 -E245 -0.0578200406695952 W547 -A552 -0.0580219505051653 W269 -T278 -0.05802827125716 A265 -A274 -0.0590388721426649 D267 -A274 -0.0600626487057498 L221 -R251 -0.0614495418564198 K220 -S258 -0.0616872751620212 H214 -K220 -0.0634041100636207 S563 -E571 -0.0634822468614065 Q219 -R261 -0.0636455516483703 Q452 -S563 -0.0636974060648365 V114 -G119 -0.0645369438111008 S234 -L456 -0.0654429026564531 Q227 -A257 -0.0661555392260427 A121 -F127 -0.0662754402724249 E215 -A271 -0.0663467170479981 V559 -A572 -0.0669718164979303 A448 -A558 -0.0673343909858133 R120 -F127 -0.0673457263793331 F222 -A257 -0.0673578565942364 P275 -I281 -0.0674822963957853 G250 -Y259 -0.0680419477760879 E248 -S256 -0.0688581097087775 H214 -R268 -0.0692207983754329 S112 -F118 -0.0693465192482385 L550 -A569 -0.0695770232452491 R120 -D128 -0.0701231131669473 A265 -L273 -0.0707418319435815 Y259 -L264 -0.0710599117583923 R224 -Q232 -0.0711808179053524 A552 -A568 -0.0717435685829517 A448 -T561 -0.0720736125960961 E215 -L273 -0.0721100103841308 R249 -S256 -0.072576399682535 G454 -V562 -0.0729844147759646 Q232 -F252 -0.0733700952694392 F252 -A257 -0.0735843436664538 A271 -T278 -0.0738790798880276 S234 -F252 -0.0746342291316973 S115 -R124 -0.0758457553880012 M225 -L233 -0.0759179270945702 I236 -F247 -0.0763315638184174 L126 -S134 -0.0765616254878712 L221 -A265 -0.0766321672895796 L279 -A287 -0.0768523783983843 E215 -L264 -0.0769751594791055 R244 -G250 -0.0770035597491372 P441 -V449 -0.0772199928547079 Q232 -E245 -0.0776833852107421 F118 -L126 -0.0781121545420032 F247 -S256 -0.0787350697101785 D267 -V276 -0.0792872384034133 L233 -F252 -0.0804648873393559 Q227 -Q232 -0.0805730533882401 Q452 -V562 -0.0808086864499122 I447 -A557 -0.0808771193440663 A271 -L279 -0.0819507297637911 Q219 -T262 -0.0829216653724698 A548 -E571 -0.0829932719028954 S285 -W290 -0.0835449849906187 N226 -I236 -0.0835751077719076 A558 -E571 -0.0837287924500645 V239 -F247 -0.0837990150526053 D556 -A572 -0.0850719904477789 D223 -Q232 -0.0866270597329559 V546 -S563 -0.0867714738137422 L113 -A121 -0.0887734415500931 R216 -R224 -0.0888467239249495 R268 -A277 -0.0889220242929447 M225 -S258 -0.0892037192946589 R551 -S563 -0.0893467666932835 F252 -S258 -0.0894131153366746 E231 -E248 -0.0898306445320571 L221 -A266 -0.0904948247866493 D223 -Q254 -0.0906437382005869 L550 -E571 -0.0907431114368009 Q227 -G253 -0.0908872309775903 Q219 -L264 -0.0917523190148373 D440 -I447 -0.0920353369963767 E248 -A257 -0.0921351653909068 G117 -L126 -0.0921692883916405 V238 -R249 -0.0922041081356815 V229 -S258 -0.093080863134873 L550 -A568 -0.0930929482685334 R224 -R251 -0.0931715692423198 I281 -L288 -0.0934292292490187 L550 -I560 -0.0935507236672116 A549 -E571 -0.0936046351237972 W547 -Q564 -0.0940257376106211 M135 -G453 -0.0942154865791593 R551 -V562 -0.0959564494330074 R124 -W133 -0.096174768242602 E215 -Q270 -0.096273712326163 Q232 -R251 -0.0965667453843344 Q219 -S260 -0.0968088841152523 I447 -S553 -0.0970683797048482 S553 -A572 -0.097325269348584 D440 -R445 -0.0980925271278534 R224 -S258 -0.0982059063958312 G217 -R268 -0.0982172101497989 I281 -V289 -0.0987602647424395 R237 -F247 -0.0995474968317556 V228 -E245 -0.0997003585372989 P451 -V562 -0.0997780080174326 G217 -W269 -0.0998814516070765 T262 -D267 -0.100601264963878 L550 -A558 -0.102389573042303 L273 -I281 -0.102394014141553 S234 -R249 -0.102560572844459 W547 -V566 -0.103577373184026 L218 -M225 -0.103850812883428 Y259 -A265 -0.104515005857446 L550 -V562 -0.104655658312155 V450 -S553 -0.105558239363631 Q232 -C242 -0.105672599955332 N226 -V255 -0.105768725419211 L110 -G119 -0.106138752284501 G111 -R120 -0.106758985626741 L550 -A572 -0.106900312541177 R251 -S260 -0.107089732922174 W547 -A569 -0.107828938015667 V449 -L456 -0.108056583055535 K220 -N226 -0.108259465929418 V239 -E245 -0.108474995817829 V449 -S563 -0.108507937148368 S446 -I560 -0.108581767579467 L550 -P555 -0.10899595660222 L122 -V130 -0.109483519147881 R224 -L233 -0.109940487752735 V255 -L264 -0.11067409646248 S234 -R244 -0.11105611569235 R216 -W269 -0.111371145307639 A549 -P555 -0.111454634266634 V228 -G250 -0.1115720425712 F252 -R261 -0.111705556965005 F222 -R251 -0.112039822244926 I236 -G250 -0.11222014882626 V228 -G235 -0.112255400174318 G567 -D573 -0.112618178344319 A448 -Y455 -0.113070231929549 H214 -L264 -0.113718533384568 F118 -F127 -0.113805905214349 V114 -L122 -0.113977216163514 F222 -R261 -0.114015992532051 W269 -P275 -0.114105257830837 L273 -S282 -0.114142788837043 G250 -S256 -0.114454027200661 F222 -F252 -0.114958129620346 Q232 -R249 -0.115979266496973 A263 -W269 -0.117536583196089 A263 -L272 -0.118168094096561 V228 -F247 -0.118257947535327 G217 -N226 -0.119441131374808 I560 -V566 -0.119804471364789 D223 -F252 -0.121225104259488 A274 -L279 -0.121510864541603 F222 -D267 -0.121696804342263 R123 -D128 -0.122052648444047 L221 -Q227 -0.12250398932871 G119 -E125 -0.123396771943516 G250 -A257 -0.123476501696081 Q227 -I236 -0.123632066929337 V229 -G235 -0.124316204397802 V280 -W290 -0.125433775066979 D128 -W133 -0.125458782973651 W547 -V562 -0.12643705076674 A277 -S285 -0.127126201791029 S112 -A121 -0.127423701428192 V114 -A121 -0.12747499351104 V228 -G253 -0.128423102331106 L233 -A243 -0.128814348626777 G119 -L126 -0.129072388811191 G235 -F247 -0.129228011973115 E215 -T262 -0.129429037330965 P555 -T561 -0.130432119456005 V229 -F247 -0.132877830351607 R216 -Y259 -0.134667190697125 Q452 -Q564 -0.134806196024459 H214 -A263 -0.135539145612221 F118 -R123 -0.136777472153205 S112 -G119 -0.139145440207539 C242 -F247 -0.139387056465273 T561 -A568 -0.13948883700387 D556 -E571 -0.13966212292992 A274 -L283 -0.139834511036327 P555 -A572 -0.140925625213651 V229 -R249 -0.142298394672459 G253 -Y259 -0.14314886913143 L110 -F118 -0.143740376939807 A548 -C554 -0.143941300800835 P441 -I447 -0.144222363642326 N226 -T262 -0.144280369793597 L221 -L264 -0.144952653302067 L444 -A558 -0.145341945744271 I236 -E248 -0.146267956050468 L110 -G117 -0.146635247278237 M225 -R251 -0.146770895067954 F247 -G253 -0.147006526976492 Q219 -Q227 -0.147727357502934 G217 -S258 -0.148632228779885 L218 -S258 -0.14902343038241 G253 -S260 -0.150158302453326 R124 -V130 -0.150847106450212 F252 -Y259 -0.150993215236996 V114 -R120 -0.151010435217829 V239 -R249 -0.151194115745801 L113 -L122 -0.151217905299886 L272 -L279 -0.151707867322634 L218 -R268 -0.151998268224073 Q219 -A266 -0.152611977424023 R249 -V255 -0.153044601111606 W547 -E571 -0.153302682363105 A552 -D573 -0.153337362493162 S256 -A263 -0.154108383331365 L221 -F252 -0.154246074393121 F222 -V229 -0.154328872798932 R551 -V559 -0.154610216546181 F118 -R124 -0.15486733118741 V546 -A568 -0.156451340060241 F222 -E231 -0.156784447330592 G253 -S258 -0.157449326469995 R123 -V130 -0.159372498135022 E215 -L272 -0.160685995217009 M225 -E248 -0.161245433669876 W547 -I560 -0.161546698636601 A448 -D556 -0.16184751749267 R244 -G253 -0.162201839994092 V562 -G567 -0.162482847010137 V229 -E248 -0.162501681243818 A548 -D556 -0.163098892450137 V229 -R251 -0.163275638328178 V280 -A287 -0.163484776440046 R216 -A266 -0.163968487514998 A277 -L283 -0.164206596685684 L221 -R230 -0.164675632841548 T561 -V566 -0.165365716362281 N226 -E231 -0.165755816200237 L221 -V228 -0.165769706399681 E231 -R249 -0.165802660554335 A548 -P555 -0.165918923693677 M225 -A257 -0.167656155888359 L550 -S563 -0.169064989253262 K220 -T262 -0.169211536645235 R123 -G132 -0.169214027315984 R251 -A257 -0.170462687639576 R551 -A572 -0.170505501325504 R230 -E248 -0.171287279266603 G111 -G117 -0.17169812585342 V255 -R261 -0.17204002480623 R237 -G246 -0.172130443196057 A548 -A568 -0.172276040932114 E442 -V449 -0.172565121710521 V546 -E571 -0.172685168783499 G246 -F252 -0.172939577572825 V450 -L550 -0.173385115241206 L273 -V280 -0.173685926556557 A448 -V559 -0.173713581528714 L218 -A265 -0.174336724445581 A271 -A277 -0.175463753527461 D556 -D573 -0.175703338627265 N226 -L233 -0.176199661489679 M225 -S260 -0.176254163544563 H214 -D223 -0.177307121185424 I236 -A241 -0.177374799912856 Q227 -S256 -0.178447165434513 L221 -D267 -0.179248251985016 L550 -D573 -0.179434929242698 R216 -A263 -0.179656849176287 G117 -R124 -0.180417756175898 E125 -T131 -0.180871719011406 V450 -T561 -0.182386492447927 V449 -G454 -0.182933706817841 S563 -A570 -0.183647521452685 R551 -A557 -0.184962560177958 R216 -F222 -0.185600176032009 L218 -S260 -0.185914966269888 K220 -V255 -0.187478953514955 H214 -L221 -0.189394380826128 R268 -A274 -0.189449955770141 G567 -A572 -0.189832932970988 L272 -A277 -0.190418877553894 A243 -R251 -0.190651799335122 I236 -C242 -0.190704952063226 Q219 -S258 -0.190848959086373 Q227 -S234 -0.191047039034913 W547 -S553 -0.192481247235234 N226 -G235 -0.193114262921396 R565 -A570 -0.193699399326441 S553 -A558 -0.193778267300774 Q452 -T561 -0.195008609091071 E442 -I447 -0.195217285496064 L221 -V229 -0.195254692624982 S282 -L288 -0.196714939127722 I560 -A569 -0.197420380209449 V450 -W547 -0.199283288277196 V450 -I560 -0.199363671468605 R230 -V238 -0.199739972300236 L122 -R129 -0.199950907225568 L113 -R120 -0.200389728301497 V546 -R565 -0.201098545678425 S258 -A265 -0.2034278874187 K220 -Q227 -0.203487241995338 S115 -L122 -0.20401092924712 K220 -L264 -0.204752771001158 D267 -L273 -0.205118849004177 G217 -R224 -0.206425760490727 G217 -R261 -0.207694011795261 R237 -A243 -0.208968785680623 K220 -V229 -0.209996000465247 L264 -Q270 -0.210393510641927 V130 -M135 -0.210892161377028 H214 -A266 -0.211348432446116 I281 -V286 -0.212555000907486 G217 -F222 -0.212759973597005 S256 -T262 -0.214159375826457 V449 -T561 -0.214500440326947 E245 -G250 -0.215115257742223 S115 -A121 -0.215308143017473 A274 -I281 -0.216114756011349 F222 -A263 -0.217368544820182 S284 -W290 -0.220036324360269 S260 -A266 -0.220802038439428 V228 -Q254 -0.222511363714184 R551 -D556 -0.224761354030374 L221 -Q254 -0.225080541825443 V450 -L456 -0.225938002604365 K220 -A263 -0.228877436945847 D128 -E442 -0.229840949145582 A448 -I560 -0.230739231655348 A266 -L272 -0.231062764482029 R261 -D267 -0.231441853535679 R216 -M225 -0.233986521487692 A257 -A263 -0.23508989784597 Q227 -F252 -0.235484120675658 I447 -I560 -0.236797632622411 T278 -S284 -0.236999666105419 I281 -A287 -0.238072417784128 R224 -F252 -0.238907426329169 T561 -A572 -0.240591558352833 V114 -R123 -0.240697740414044 L264 -A271 -0.241284801856388 A265 -L272 -0.241818137446139 F127 -G132 -0.24312337917504 H214 -R261 -0.244570461442937 L272 -T278 -0.244997826211541 L113 -F118 -0.24549594896409 A265 -A271 -0.245567961602326 R445 -V559 -0.246165751637544 R551 -A568 -0.246355045673839 A552 -A557 -0.246687974188504 V546 -A552 -0.247585324459873 E248 -G253 -0.247727234882657 K220 -Q254 -0.25097265634427 I447 -A558 -0.252049648812132 P275 -V280 -0.252379701430786 L264 -W269 -0.253726329626062 L218 -D267 -0.254472214125779 L122 -F127 -0.257364417166423 L221 -A263 -0.258216289160345 S282 -A287 -0.258734516203521 R120 -L126 -0.260401644508436 L126 -T131 -0.261275096654748 A257 -L264 -0.262649680112023 S112 -G117 -0.264443023984301 F222 -V228 -0.26606550933834 V255 -T262 -0.266640346563908 L122 -D128 -0.266739068658749 A266 -L273 -0.269392220393297 C242 -E248 -0.271179348404839 L218 -W269 -0.271859846646004 G217 -A265 -0.272605082601658 C554 -I560 -0.274082632518145 Q219 -M225 -0.274830265190694 L550 -A557 -0.27561479753945 L218 -R224 -0.279232810318891 F222 -S258 -0.279885792160996 L273 -L279 -0.282380587302109 D223 -V255 -0.283070976540731 E245 -F252 -0.285498350067201 Q232 -E248 -0.287029673316771 F222 -S260 -0.28981785842159 L233 -V238 -0.289849510309848 V559 -D573 -0.29286294410428 I236 -A243 -0.293397229356416 L283 -W290 -0.295045378497264 A274 -V280 -0.296286891792867 L218 -L264 -0.297454860831472 D223 -V229 -0.301488095381495 A121 -L126 -0.302805827657025 V228 -S234 -0.303595030135147 V450 -Y455 -0.303823906957561 V566 -A572 -0.307397924003426 L273 -T278 -0.312944311456411 V229 -V255 -0.314025154585819 V546 -S553 -0.315869711353383 V566 -E571 -0.315916801585756 S258 -A263 -0.316934729415133 S258 -L264 -0.31765443100457 G111 -M116 -0.318189788929438 P275 -S282 -0.32092696423206 T278 -L283 -0.324821848184078 V228 -E248 -0.326757380712167 N226 -S256 -0.32778326184664 P441 -S446 -0.328172695867637 F127 -W133 -0.328829491936412 S553 -V559 -0.329020056997063 L113 -G119 -0.329061117220153 F247 -F252 -0.330832756167117 L283 -V289 -0.331240995111553 V449 -V559 -0.334183658714552 M116 -A121 -0.338345266182067 S234 -V239 -0.339302627743166 V562 -A568 -0.340232479624421 M225 -Q254 -0.341372118092457 L126 -G132 -0.343313567997759 V229 -S256 -0.344286944620683 V280 -V286 -0.349020398176099 L221 -S260 -0.352248654907241 V450 -V562 -0.353084561721294 L550 -V559 -0.356803916668922 V276 -S282 -0.357909467369773 L110 -S115 -0.358996705381192 V280 -S285 -0.360341570307668 W269 -V276 -0.362403008395717 A549 -C554 -0.372286724867954 A266 -A271 -0.373371846360782 A257 -T262 -0.37548681379224 E215 -F222 -0.377322198609411 L110 -M116 -0.38390993455338 Q270 -V276 -0.392191973914479 G117 -L122 -0.40283152439 W547 -C554 -0.403683597975501 L283 -L288 -0.408778979989844 C554 -E571 -0.427723372638687 F222 -Q227 -0.431825399044466 Q227 -V255 -0.437562844051352 F118 -E125 -0.440877977264468 V562 -A569 -0.451363995786634 A271 -V276 -0.453985562166687 Q227 -L233 -0.459201848543933 V229 -I236 -0.461618701255345 N226 -Y259 -0.461767156612419 G217 -A263 -0.474756335349823 M116 -L122 -0.477453369683538 G217 -A266 -0.479420527507297 V276 -I281 -0.485505635290998 A548 -S553 -0.502888425319274 A277 -S282 -0.542848034716591 S260 -A265 -0.543379547191466