[Fri Aug 26 18:19:04 2016] >Input file: TMQ3KAT5M1D.pdb >TM segments: 78-97_ 104-128_ 132-160_ 163-184 MAIDEN score = -6.5242 Below is the ranking list of the residue pairs and their related pseudo-energy (the lower, the better). This includes inter-chain residue pairs. The maximum (least favorable) pairwise energy value has been set to 10. See the MAIDEN software article: Postic,G., Ghouzam,Y. and Gelly,J.C. (2015) Biochimie, 115, 155–161. ----------- ---------------- Calpha pair Empirical energy ----------- ---------------- L158 -V163 2.33345652722538 V122 -W181 1.01084938464502 V125 -W181 0.998322890582351 I116 -V168 0.940510087701594 F118 -L177 0.88003825793069 I116 -N172 0.840846125909719 F118 -V173 0.836630017308992 A115 -T147 0.792333420583236 T150 -F169 0.768994027047411 T149 -F169 0.686375205209139 A115 -M144 0.683951286568576 A115 -V168 0.633695457792273 D127 -A137 0.627806358693642 V125 -Y184 0.624904717672694 V109 -T150 0.62405434412846 A123 -M138 0.617270566226169 L112 -V168 0.599698177503761 F118 -A180 0.582309482230718 A114 -M144 0.564798227800561 A115 -N172 0.560154391419633 S91 -L155 0.543243962756645 L151 -F169 0.52737815177969 S91 -G156 0.519593144240403 R78 -I84 0.515244519372335 V93 -G156 0.515152277493189 A90 -T150 0.505270158699401 F87 -L151 0.504816417949166 V93 -A106 0.494174739641117 S154 -G164 0.47140947935317 G111 -V168 0.469924206202377 L112 -Q166 0.457063193047775 S154 -W165 0.443175683949131 Q110 -V168 0.415808648320497 V168 -V173 0.412782021499235 A114 -T147 0.40663282940213 A126 -Y184 0.403123655912797 V122 -L177 0.397709668065763 I116 -G176 0.395451287799014 I116 -V173 0.394688817643219 A90 -P153 0.394385287282049 M117 -W181 0.391754748757831 D127 -M138 0.382699073096354 L124 -M138 0.37429608545012 Q110 -Q166 0.37424704670703 I116 -F169 0.373653599487874 P174 -N179 0.36422638454171 T121 -L177 0.35798905794765 A95 -A106 0.35716502979307 T88 -C94 0.35350219325524 A90 -A108 0.34977755366311 L120 -M138 0.342751802023196 L158 -G164 0.342292177995586 T121 -G176 0.337328951363569 A119 -T143 0.336037293675837 A108 -L151 0.333871754438679 M117 -G176 0.326478590372118 A114 -G148 0.325668192603828 G111 -A146 0.319495459371576 S91 -A108 0.318863231870774 F87 -G152 0.317924733304973 A114 -A146 0.316053954321832 R78 -G83 0.315803955570426 G113 -G148 0.313247087377147 F118 -L175 0.309473128194218 A106 -G157 0.307341068159945 A97 -G105 0.304849308678145 A90 -L151 0.302450190539607 L120 -L141 0.298481511502449 T147 -P153 0.293289375974064 V109 -T147 0.289796988558132 L112 -A146 0.287484063822325 M117 -V125 0.28556634521216 R107 -M160 0.285463905726353 L92 -G157 0.284701099068413 A128 -G139 0.284064036360715 F118 -N172 0.28171458447376 L140 -G148 0.281006272638836 A106 -S154 0.280384125095845 G83 -L151 0.279871288312032 L124 -A134 0.278897043366663 V125 -A180 0.278570450350319 G135 -L141 0.275117737502403 A106 -G148 0.273577606429344 S154 -V163 0.269210154133353 G105 -P153 0.265862104701171 T121 -W181 0.265424431171742 A119 -A180 0.265329864537613 L120 -L177 0.264425818900719 F118 -N179 0.26438696548662 M160 -W165 0.262496152304073 D127 -Y184 0.261274684085224 T149 -P174 0.260183761154085 A123 -S136 0.257596397826845 G105 -L159 0.257435125510754 G111 -N172 0.253659541685118 Q110 -G157 0.251361561581344 A90 -R107 0.249863576775255 Q110 -A115 0.247062558561126 G156 -W165 0.244930502878892 A123 -A128 0.241977769537988 T147 -Q166 0.241855279848482 G152 -G164 0.235340678424691 L96 -P153 0.231839560771615 R107 -G148 0.22779809435963 A119 -G148 0.225314409537543 A126 -R133 0.223048998848498 G152 -Q166 0.222934729136012 M144 -V168 0.220497081943476 P153 -Q166 0.216871684955619 I116 -T147 0.214786471973289 A89 -A95 0.211489879192881 L120 -V173 0.210149638971113 Q110 -T149 0.209291660795915 S91 -P153 0.208962554077049 A128 -M138 0.208836969765691 A146 -F169 0.207616032077491 G111 -T150 0.207186134270249 G105 -G148 0.203730407968797 I84 -T150 0.203412166491977 G113 -Q166 0.201458423226163 A123 -G135 0.201166400493832 F118 -V125 0.200647824446517 I86 -G152 0.199655426047189 I104 -T150 0.198806342138521 G148 -N172 0.198602451019819 Q110 -T147 0.195531508553218 L124 -N179 0.194330321886076 V122 -L182 0.192299070495564 A119 -T149 0.189074099112852 A119 -Y184 0.18725459267511 T147 -I171 0.184979101873548 A119 -A126 0.184014641807927 A115 -I171 0.183864866308294 M117 -V183 0.182817326656536 C94 -R107 0.182621693114831 V125 -L182 0.18242008245103 M138 -G148 0.175449654032428 L92 -G152 0.174083043018985 T121 -T149 0.173723488590002 A126 -S132 0.17318341532676 L120 -G135 0.172227895638808 T143 -T150 0.171547778373618 A115 -T121 0.170381417228484 S91 -R107 0.16811013006709 G152 -W165 0.16810292604433 A146 -G164 0.167215984969137 T121 -N172 0.166605709411298 L120 -T149 0.166309729677 A95 -G157 0.165743065523594 L151 -N172 0.163708251808886 G152 -F169 0.163323501223498 G111 -G148 0.162762905996373 G105 -G164 0.16263921846088 C94 -G105 0.161877484766865 G105 -G152 0.161851560427699 S145 -P153 0.161694761256921 A123 -G148 0.161636831452177 I171 -G176 0.161132822487316 T150 -G164 0.160755340784643 I116 -T150 0.160110796052335 A108 -G113 0.160006063655173 T88 -L155 0.159039812478527 T149 -W165 0.15857623680899 G148 -G176 0.158332914150165 G85 -L151 0.157039138794632 D127 -W181 0.154828530323933 A119 -L177 0.153971152536563 T121 -A142 0.148945193940298 A90 -A95 0.148607282914805 T121 -T147 0.147794952474679 P174 -W181 0.146840771069471 S136 -A142 0.146115925411817 I116 -G148 0.145934820950128 V109 -S145 0.144906360788405 V109 -V170 0.144077217194162 L151 -V170 0.143807576614448 L96 -M160 0.142045331289885 S167 -P174 0.14091164136849 V168 -G176 0.13998654095356 G105 -T149 0.139539093886212 G111 -M144 0.13921110955597 T121 -L178 0.138218191069065 A115 -S167 0.137881828290574 G113 -T149 0.137550840302358 T150 -I171 0.137321147306985 R107 -G164 0.136342618650377 Q110 -G152 0.135851422305769 V125 -S132 0.133571934365063 T149 -G164 0.133485650089165 A119 -A128 0.133206459046973 G113 -F169 0.132849143318225 A89 -A106 0.132525273492438 L81 -T88 0.129925529358022 L92 -L158 0.127313971574013 I86 -T149 0.127263619423827 A123 -R133 0.126080362680869 V170 -L177 0.1252365116851 G148 -P153 0.124302743521562 Q110 -I171 0.123786897356546 G157 -Q166 0.12325366571893 Q110 -G164 0.123102841586824 A108 -G148 0.122902519821213 F87 -G156 0.122843560391238 G164 -F169 0.122225301224816 S91 -L151 0.122099557996755 V109 -T149 0.119628608569869 G111 -I171 0.11883850366464 R107 -Q166 0.117860607110315 G83 -T150 0.117741528596962 T121 -G139 0.116709201003935 V163 -V168 0.116319858133202 L124 -S136 0.115335163751774 V109 -S167 0.11498894783511 A119 -L178 0.114409283643844 A114 -I171 0.113935199455163 S91 -L159 0.113932529365689 A146 -S154 0.110953872388452 S91 -T149 0.110832698791716 G111 -Q166 0.110604894321181 L124 -L178 0.109812369343224 G113 -V173 0.109805016778128 P153 -L158 0.109760782063075 A128 -A180 0.109443446516738 L112 -V170 0.109420508847816 V122 -L141 0.10881888669943 L92 -G105 0.10807862953581 A114 -L177 0.107329973341576 A119 -G139 0.10728457468826 A97 -G157 0.106402514164989 G113 -I171 0.106363711348219 G113 -T143 0.106329075242373 L120 -L182 0.106294137587222 G111 -V170 0.105477553244425 T121 -V170 0.104841562013265 A119 -A146 0.10467526485013 R133 -G139 0.104517057389048 V122 -A134 0.10448828510469 I84 -L92 0.104208748116796 T88 -S154 0.103756278236215 V109 -L158 0.103571967538855 A106 -L159 0.103391502910884 S91 -A97 0.1032796682819 G105 -G111 0.103194169993063 G156 -G164 0.103044269360216 A146 -S167 0.103025206029575 V122 -G139 0.102512107362123 G156 -V163 0.102492136088765 A89 -P153 0.102334562855433 T149 -V163 0.10212667593283 A95 -G156 0.101702498174206 V93 -P153 0.101496868537723 Q166 -I171 0.101116128080693 D127 -G139 0.101008163316108 T150 -G157 0.0998478908386445 I104 -G152 0.0993323634622036 A123 -S132 0.0989139175083702 D127 -L141 0.0987926407704567 V122 -L140 0.0986575863595174 G83 -V173 0.0985390197208251 I86 -L155 0.0981578592450578 A123 -L182 0.0978287489246799 A90 -G148 0.0970261122133834 Q166 -N172 0.0967370762979723 L120 -P174 0.0964072632143902 M117 -S167 0.0964050971534003 V168 -L177 0.0963481699917985 G113 -A119 0.0963185804848798 A123 -L178 0.0961802438677595 T121 -P174 0.0961277406256258 T149 -S167 0.0960974937881658 A108 -G157 0.0955343277097782 A90 -G157 0.0946537984772793 A114 -A142 0.0945106372463593 G139 -G148 0.0943828195772989 F118 -Y184 0.094085205156305 M117 -L124 0.0937362096138887 L124 -V173 0.0928705584874479 G148 -V170 0.092545386411891 A119 -V168 0.092517078485395 A89 -T150 0.0923529943575234 L79 -L177 0.0921401840410152 I104 -L151 0.0921273477455063 V93 -S154 0.09185547831237 V122 -T147 0.0908531544792335 T88 -A95 0.0907715345405293 A115 -L175 0.0907226636487093 L124 -A142 0.0887892686551464 A95 -I104 0.0885196834662221 G105 -T150 0.0882791313149054 A108 -A115 0.0880433598012025 T88 -G156 0.0873963609356537 V170 -L178 0.0873853500904596 L79 -L178 0.0873801079473759 C94 -P153 0.0872385280874708 I116 -T121 0.0867440927546911 A115 -L177 0.0865212564199322 T147 -S154 0.0859268684813735 V125 -G139 0.0858022143252072 N172 -L177 0.0853268119062109 I116 -L151 0.0852521448488242 Q110 -P153 0.0852462339675846 A126 -S136 0.085179055895642 L92 -A108 0.0848185464890423 L92 -S154 0.0839017659391055 M117 -L141 0.0835177548673989 C94 -A106 0.082866514031263 A108 -L159 0.0826939890131178 G111 -V163 0.0825478212325602 A146 -V168 0.0816877770827049 T147 -S167 0.0813723082407001 F169 -L178 0.0807384502982771 A89 -C94 0.0804932352154044 A90 -L96 0.0802229355195112 C94 -S154 0.0796488425992397 I116 -N179 0.0789902037161618 I104 -G156 0.0787001393985483 L120 -F169 0.0784771190230829 M117 -A142 0.0778160951612382 G152 -S167 0.077412058224485 I104 -M160 0.0770338953435741 N179 -Y184 0.0769182044432393 L92 -L151 0.0767493699612727 A119 -L182 0.0759557512255693 G111 -W165 0.0754445596058435 L141 -G148 0.0750877442127349 F87 -L92 0.0750201361551337 I116 -L141 0.0749483714280301 A119 -S145 0.0743605869693744 G113 -V168 0.0742867388019448 L120 -V183 0.0741910184785513 G105 -S145 0.0738583596284976 G85 -G152 0.0737702159989124 M117 -T149 0.0728312003075842 Q110 -M144 0.0727636546261912 G148 -Q166 0.0723476946316897 A90 -I104 0.0717750215634876 V109 -I171 0.0717370967748452 G83 -G152 0.0716679788667447 L124 -R133 0.0714197593910636 I86 -V173 0.070317338623429 T150 -W165 0.0696415955316407 M117 -Y184 0.069361353892375 L80 -T88 0.0691680030804973 L120 -S145 0.0685610505502741 T121 -F169 0.0684438370884529 S154 -V168 0.0681456116932337 A123 -N179 0.0679388701205235 L120 -M144 0.0671969010432378 L112 -V173 0.0671246688720846 V125 -A137 0.0661143051075346 M117 -N172 0.0660999723816813 N172 -A180 0.0660014496733201 T149 -I171 0.0658739664701944 G113 -N172 0.0652037180106675 A137 -T143 0.0648822692606768 A89 -R107 0.0645504620505115 I86 -V170 0.064208206562995 V109 -N172 0.0633229589426885 I104 -A146 0.0630344069508153 A89 -G156 0.061166274305883 S154 -V170 0.0611486699775639 V125 -N179 0.060476330488155 G135 -A142 0.0595273524378654 R107 -L155 0.05941967048064 T121 -L141 0.0587424422570724 A123 -T143 0.0586921459656367 S91 -W165 0.0574744647718095 L96 -G105 0.0574553302702447 S154 -S167 0.0572502798039412 L112 -G148 0.0571056891985013 L92 -I104 0.0564442575638258 G148 -W165 0.0561944792750582 I104 -L158 0.0558486396756379 G148 -V173 0.0551714099637124 S91 -L158 0.0551495490634732 T150 -L155 0.0547665396740911 V122 -A142 0.0528962914183939 I104 -G148 0.0528551023821686 L120 -I171 0.0520565880682673 T88 -V93 0.0519802895815316 L112 -S145 0.0514843376024037 S91 -L96 0.0503951174544841 G85 -L92 0.0500902749132859 A106 -V163 0.0500253526485928 M117 -M144 0.0500086897196232 A108 -Q166 0.04999838481796 I116 -L178 0.0499616192080758 L96 -A108 0.0492515497080319 M117 -L177 0.0490290532933795 V93 -L159 0.0482535323605457 A128 -L178 0.0482196009017493 A126 -L141 0.0478453477079179 L112 -P174 0.0474471841589139 A119 -A137 0.0473523859391162 F87 -C94 0.0471516636238576 A128 -L141 0.0469342671901885 G139 -S145 0.0463842331497268 V122 -L175 0.0463754897403401 A108 -V168 0.0463727963689733 I171 -N179 0.0455546935242306 G105 -L155 0.0454692427324002 F118 -M138 0.0452600031097465 A128 -L140 0.04482622879233 A146 -N172 0.0443914628846973 A106 -G164 0.0442231008568124 T121 -I171 0.0439510783133095 A108 -S167 0.0439306589767927 A108 -S154 0.0424569089112161 L96 -G157 0.0422026795426298 T121 -A180 0.0421029807405862 G113 -G176 0.0417787068296569 S167 -L175 0.0415989431227703 T149 -L155 0.0415797360293046 V125 -R133 0.0413175160682575 A90 -T149 0.0410572469333816 A126 -L177 0.0407706469859055 I82 -P174 0.0407348300284127 G111 -S154 0.040620209067075 L112 -G164 0.0404453258076423 Q110 -V173 0.0402798260530841 A95 -G152 0.0395322704967191 G105 -G157 0.0379762141384168 A146 -P153 0.0375354217773092 L112 -T150 0.0373502972009994 L140 -S145 0.0369195713105275 S132 -G139 0.0368675780994367 P153 -F169 0.0368432937131194 P153 -S167 0.0368195662574582 M144 -F169 0.0367641194469428 R107 -V163 0.0356404232410404 L112 -N172 0.0352130560085446 S91 -G105 0.0349381891967977 L124 -S132 0.03485710030441 G148 -S154 0.0348030657596747 A114 -V170 0.0340076016179536 M117 -T147 0.0339497942244673 V122 -P174 0.033430215920329 G83 -S91 0.0333138003806061 L120 -A146 0.0330538742550328 G152 -V170 0.0326401281614119 I116 -Q166 0.0325839190547312 G113 -S167 0.0325682880336991 G113 -S145 0.0324665981727286 N172 -N179 0.03241426228666 A115 -A142 0.0321411544347066 A123 -T147 0.0321152034249605 G111 -L151 0.031792398120881 A115 -P174 0.0313288363356774 L112 -F118 0.0309919909212604 F87 -V170 0.0307400548387233 T150 -G156 0.0299725798527117 A119 -L175 0.0289996700439152 A97 -M160 0.0288447770406677 F118 -F169 0.0281857655975983 A128 -L177 0.0277962795607536 T88 -A106 0.0273938882961384 A106 -T147 0.027203112562268 A126 -V183 0.0271110575036042 G105 -Q110 0.026818309962525 A108 -M144 0.0267833055100966 M117 -V170 0.0266387338506955 F118 -A126 0.0265838128178779 A115 -Q166 0.0263705452524463 I116 -A142 0.026116971547399 I116 -I171 0.0261091282894332 T143 -G176 0.0260684207111985 I116 -A146 0.0258292599657359 I82 -L151 0.0257855081440415 A114 -T121 0.025451218300284 D127 -A180 0.0252854436151445 M138 -T143 0.0252283673307354 L79 -V170 0.0249521754824031 P153 -G164 0.0246622596697139 L80 -V170 0.0241840488055609 I84 -G152 0.0241379169543819 R107 -G152 0.0240501886604632 T147 -G176 0.0233074064152641 L120 -A128 0.0230676420467981 V93 -A108 0.0227602162413172 G111 -V173 0.0227174685279392 A89 -L151 0.0218728057436817 A106 -G156 0.0213251974468172 A97 -G156 0.0183218046920111 F118 -A146 0.01670473668909 G83 -L177 0.0159356239424842 A146 -Q166 0.0158999656289263 L155 -V168 0.0156340110227857 A128 -R133 0.0155105000183604 G83 -T149 0.0146377712388541 C94 -L155 0.0146291077724049 L112 -M117 0.0146137676485214 A128 -Y184 0.0128123715146049 A108 -V170 0.0127097804998044 T149 -V168 0.0126126982647179 A126 -G139 0.0122075217617243 F118 -T149 0.0119694070662242 V109 -S154 0.0116886638553115 T121 -V173 0.01144126842454 V125 -L141 0.011335399184965 A115 -L141 0.0105715015762184 A119 -V183 0.0104997888526379 A142 -T149 0.00969595262452705 I84 -V170 0.00926186206295121 A123 -M144 0.00920436561796567 A115 -V122 0.00904585415651837 L159 -G164 0.00890395291367874 A89 -L155 0.00878990076528119 M138 -W181 0.00872316413272189 R107 -A115 0.00763122188081411 Q166 -V173 0.00748542960760945 A115 -V170 0.00741738657154478 A119 -M138 0.00706885228761323 L120 -V170 0.0068528845498097 V125 -G176 0.00649954071496328 V109 -T143 0.00640998827381445 C94 -L159 0.00532305617087614 G105 -T147 0.00525577789252818 L141 -T150 0.00502350826891929 Q110 -A146 0.00436099045991334 A115 -G176 0.00373148879451612 I82 -A90 0.00309727137329485 I86 -P153 0.00199190743227518 C94 -G152 0.0014665321081333 I104 -L155 0.000603727890982952 L92 -M160 0.000502476049828005 G176 -W181 0.000410055589934011 V109 -L151 0.000397464967308636 S132 -A137 8.33149368532071e-05 A126 -L140 -0.000473936126336838 L158 -S167 -0.000806715402513081 G111 -M117 -0.00158995475958212 A108 -G152 -0.00188570342176142 G83 -V170 -0.001919600804833 A114 -G176 -0.00202506256583534 L151 -M160 -0.00209509928573937 G156 -Q166 -0.00223509723362003 R133 -M138 -0.00249186118788947 T121 -Y184 -0.00350087655673237 I82 -T150 -0.00353132982461046 L112 -G176 -0.00370715124084331 A126 -A142 -0.00380199501582812 A95 -G105 -0.0040729970845641 L96 -G156 -0.00424381707309029 V109 -G157 -0.00429879215040607 A114 -V173 -0.00465424974752082 A123 -G176 -0.00556913591032426 T150 -S167 -0.00592434978650758 G164 -V170 -0.00630643084748161 V109 -G156 -0.00668781045711553 T121 -L175 -0.00672144891805537 A114 -F169 -0.0074768454982812 L124 -T143 -0.00773010134403407 G111 -I116 -0.00805496055320809 M117 -L182 -0.00805726191380529 M117 -F169 -0.0083719960914076 A90 -V109 -0.00838743539004005 F118 -A123 -0.00907209661381314 V109 -M117 -0.00952754447590287 F87 -V93 -0.00984738352855086 T121 -S136 -0.00996070343031441 Q110 -T143 -0.00996969498433531 V122 -Y184 -0.0112418616188386 A108 -M160 -0.0112999741262843 V109 -G148 -0.0116072369123519 S167 -G176 -0.0116629088110332 V109 -V173 -0.0118466432799709 G113 -A146 -0.0122584906610963 L124 -G176 -0.0126147005920774 G105 -L151 -0.0128437235699383 I116 -S145 -0.0130601530180966 A146 -V173 -0.0132750114335849 S145 -T150 -0.0133103621515582 L155 -V163 -0.0133826986633956 L124 -V183 -0.013743018129345 I84 -S91 -0.0138082354839817 T147 -V170 -0.0141207332489373 L140 -T149 -0.0143034006031986 A95 -P153 -0.0150148049551957 L112 -S154 -0.0150698372318967 F87 -T149 -0.0150904818522051 L81 -A89 -0.0159722669410405 A119 -L141 -0.0167215858209839 A126 -G135 -0.0167233331815595 D127 -L140 -0.0169497842542126 C94 -I104 -0.0171491828855885 V125 -P174 -0.0181261101925432 V122 -N172 -0.018571885618653 T88 -G152 -0.0190571137223259 R78 -G85 -0.0191659817761218 A97 -P153 -0.0196063801533635 Q110 -T150 -0.0204974809648752 L124 -L140 -0.0209496870529211 R78 -I86 -0.0211078931509501 L80 -F87 -0.0220325394315237 Q110 -V170 -0.0221626355324784 R107 -S145 -0.0229879718086834 V109 -V163 -0.0236004545644839 V109 -F169 -0.0241609903339617 V122 -A137 -0.024717519028755 L151 -L159 -0.0247412087446879 M117 -A123 -0.0248410461578503 V109 -A114 -0.0248943510822048 G152 -M160 -0.0259946277690792 A89 -L96 -0.0266087326460571 A123 -V183 -0.0267172163374949 A126 -N179 -0.026973641735806 I84 -L155 -0.0270492943119205 A134 -A142 -0.0275029982563693 V122 -D127 -0.0275738337853308 R107 -L158 -0.0276603787754954 Q110 -G156 -0.0277562554742875 A89 -T149 -0.0279197406533647 I116 -V122 -0.0286909505481032 V93 -G152 -0.0287006443878095 M117 -G148 -0.029175625256705 L79 -P174 -0.0292537162756492 V109 -I116 -0.0293589997178874 G113 -F118 -0.0305547552664578 T147 -F169 -0.0311438545672955 L120 -N179 -0.0317168706814001 V125 -G135 -0.0319862292992195 L120 -G176 -0.0322887772297467 T150 -V163 -0.0324966937316793 V122 -G176 -0.0325221195808698 I104 -T149 -0.0331980353738501 L141 -A146 -0.033288784764121 Q110 -S167 -0.0334881462692672 G111 -P153 -0.0336838923139644 L120 -N172 -0.0346154195930148 L120 -L178 -0.0349990429567888 Q110 -S145 -0.0354374531634658 L124 -A180 -0.0360235695713453 L112 -M144 -0.0362415509501632 G139 -T149 -0.0363128077992632 Q110 -W165 -0.0369130363242918 A119 -P174 -0.0370012966752209 A106 -L155 -0.0373871375143046 L120 -A134 -0.0375837604561235 A115 -A180 -0.0377955399020635 F118 -V170 -0.0379349155032824 A108 -L155 -0.0385359982979598 V109 -A146 -0.0389135077128233 Q110 -V163 -0.0392778835750791 L120 -A142 -0.0393235272322627 I104 -S154 -0.0400005514096309 I104 -V163 -0.0400442343611775 S91 -I104 -0.0402596591760305 L175 -L182 -0.0405178942434086 T147 -W165 -0.0407724465183602 R107 -T150 -0.0408046562444664 A128 -W181 -0.0412433828153977 F87 -G148 -0.0413041112568409 M144 -T150 -0.0415342482054051 S91 -G148 -0.0415365672578705 I104 -G164 -0.0419728402437929 V109 -A115 -0.0422119085550818 S145 -V168 -0.0428361395106043 S91 -V109 -0.0428667573100805 A90 -L159 -0.043090199138712 A119 -G176 -0.0453428548470605 L141 -T149 -0.0455394577728523 G148 -S167 -0.0464119577546089 V122 -G135 -0.0467095538450701 A134 -L141 -0.0470328512670424 F118 -S145 -0.0474116096093611 Q110 -N172 -0.0479228120350261 G111 -T143 -0.0484926277608864 L92 -G156 -0.0487001998956949 T149 -G176 -0.0490622041957768 V122 -T143 -0.0494072044904721 P174 -V183 -0.0512687094612878 A123 -V173 -0.0515389107221749 A114 -V122 -0.0526831051892822 F87 -G157 -0.0530686790186742 G139 -T147 -0.053088491070883 T121 -G148 -0.0533788464709035 R133 -L140 -0.0533942661681506 F118 -G148 -0.0535775173009143 V125 -L140 -0.0542657579121695 Q110 -S154 -0.0551464342997261 I86 -G156 -0.0551836416866336 L155 -G164 -0.0553488247418308 T147 -G152 -0.0556658188845556 G105 -M160 -0.0566632026503675 A114 -L141 -0.0569175004209406 G157 -V163 -0.0569181407650028 L155 -F169 -0.0573359624210319 R133 -L141 -0.0575091839998132 T149 -G156 -0.0576322396612303 I82 -S91 -0.0576362097812484 F118 -A142 -0.057904908652838 G176 -Y184 -0.0580328022466834 G113 -M144 -0.0582570636135538 A89 -S154 -0.0589922565476098 A119 -D127 -0.0597575285112493 L140 -T147 -0.0598842280226988 G105 -A146 -0.0603826538584606 A90 -G105 -0.0604740303117884 I104 -V109 -0.0609979223927919 I86 -S154 -0.0611047047429616 A119 -N179 -0.0613091705397504 F118 -P174 -0.0621123171030313 V122 -N179 -0.0622904162318967 C94 -M160 -0.0623261171965774 M144 -N172 -0.0624136708395406 L124 -L182 -0.0626373598190799 Q110 -L158 -0.0629368609737051 G85 -T150 -0.0635054649481015 A114 -L120 -0.0635062066169061 A115 -W165 -0.0635953778926207 T143 -T149 -0.063765916144443 V109 -P153 -0.0639963312991743 L155 -S167 -0.0647874215890378 T150 -N172 -0.0661232184716294 D127 -S136 -0.0664339095601465 T150 -L158 -0.0666537189206244 A146 -W165 -0.0678789069602331 S154 -F169 -0.0679113952226993 D127 -S132 -0.068148033548649 Q110 -L155 -0.0687585849015911 A106 -A146 -0.068952372623551 G83 -P174 -0.0691763829294776 T121 -M138 -0.0698585287384734 T149 -G157 -0.0707775487886027 L79 -V173 -0.071691624522586 M117 -V173 -0.0716933079100031 T121 -G135 -0.0718996893539372 G83 -A90 -0.0725222677660968 G111 -T149 -0.0727358548910066 R107 -M144 -0.0730396838726977 T121 -A134 -0.0737501042417041 I104 -L159 -0.0737941939418985 A123 -G139 -0.0738975391697565 I171 -L178 -0.0743398524130345 L112 -T143 -0.0746927931030417 A108 -T149 -0.0748164964592481 A114 -N172 -0.0748426806113609 W165 -I171 -0.0749324766952819 T143 -N172 -0.0753181122186311 D127 -G135 -0.0753902212377788 L79 -T88 -0.0754367121020469 T121 -L140 -0.0758280948529246 V93 -T150 -0.076050691746663 C94 -G157 -0.0762326940531538 R78 -F87 -0.0766057001418092 P153 -V170 -0.0766067490064812 P153 -V168 -0.077301884433459 A126 -L182 -0.0782544968118186 I86 -G148 -0.0787131599835988 L80 -P174 -0.0798882725870724 S145 -F169 -0.0799211081469402 I104 -S145 -0.0811195495875845 A97 -R107 -0.0816965922387123 V122 -V173 -0.0830029241939227 L155 -Q166 -0.0833839023599223 G152 -L159 -0.0843287134861264 G83 -F169 -0.0867004978335757 I116 -L175 -0.0868255357909522 R107 -G157 -0.0870954303567938 T121 -A128 -0.0875179290749213 A119 -L140 -0.0881303707267378 M117 -L178 -0.0883243121943531 A106 -W165 -0.0889296612492063 A114 -S167 -0.0897502693735568 I104 -Q110 -0.0901319083356569 A142 -G148 -0.0902094757943277 I171 -A180 -0.0903160350386472 L151 -V173 -0.0905921775096026 A119 -N172 -0.0916217387293633 T147 -L177 -0.0918926292959792 T149 -L177 -0.0919968999259371 I84 -L151 -0.0928471226029788 A108 -T150 -0.0929649421568699 T121 -N179 -0.0930174772479858 I116 -A180 -0.0930323097343936 A108 -T147 -0.0932563301804719 P174 -L182 -0.0942660784094933 L151 -Q166 -0.0955090004920613 V170 -N179 -0.0961934827984936 M138 -L177 -0.0965813835029815 I86 -F169 -0.097217902345597 F118 -L182 -0.0972228569178397 L92 -T150 -0.0991549817557207 A97 -L159 -0.0996234090944208 A114 -Q166 -0.0996270640426875 A90 -L158 -0.100047251290626 F87 -F169 -0.100140412834525 R107 -T149 -0.100167074344538 L120 -S136 -0.100287604669747 A123 -A137 -0.100598424705151 A106 -T150 -0.100711028828432 M117 -A180 -0.101332096338082 V125 -S136 -0.10175764322906 T150 -V173 -0.101828461833243 T121 -A137 -0.101937166015902 L155 -V170 -0.102854822249723 L124 -L177 -0.103000011077153 V93 -G157 -0.103185942989138 G152 -V168 -0.103854898443179 A142 -T147 -0.103956198724779 A108 -F169 -0.104270079442595 L120 -Y184 -0.104417280697676 S132 -M138 -0.10463419328151 G113 -V170 -0.105386839677302 F118 -V168 -0.105622224684211 L158 -Q166 -0.106436060006669 I82 -G152 -0.106745461478287 G148 -F169 -0.106932744143397 L120 -T150 -0.107022940115325 R107 -S154 -0.107266898448698 M117 -L175 -0.108149975102577 L96 -G152 -0.108575608311503 M117 -N179 -0.108884243447999 C94 -G156 -0.109811074598334 V173 -L182 -0.110691344991675 F87 -A108 -0.111067346403894 F87 -L155 -0.111528027115793 R107 -L159 -0.111545146641907 P153 -W165 -0.111693721356819 A108 -W165 -0.112125951308538 A114 -T143 -0.112449025862537 V93 -L151 -0.112475118302424 S167 -N172 -0.114605827708182 Q166 -P174 -0.115038940814669 A106 -S145 -0.115489766530716 A119 -W181 -0.116005010596712 R107 -F169 -0.116972280737436 F169 -L175 -0.11705511899517 L151 -I171 -0.117934557569586 I86 -L92 -0.118196253748071 S91 -M160 -0.118682535267698 P153 -V163 -0.118895149430448 F87 -T150 -0.118956872708487 A95 -R107 -0.119870075081282 A115 -L151 -0.12097373847083 V122 -L178 -0.121247809608974 L158 -W165 -0.122564395655839 I86 -V93 -0.12259487378063 F118 -L141 -0.122914748981222 A114 -T149 -0.123023661732035 A115 -V173 -0.123317381122736 L151 -V163 -0.123713175069722 F118 -V183 -0.123803201838825 L81 -F87 -0.123821826944474 L112 -L175 -0.124497923371985 G176 -V183 -0.124809932791531 D127 -A142 -0.12504340313756 L124 -Y184 -0.126169720719653 I116 -T143 -0.126866382431754 G105 -W165 -0.127865161826677 F87 -V173 -0.128662679918285 T143 -V173 -0.128966390591093 A146 -L151 -0.129279753381029 A115 -T150 -0.129841170103961 V173 -W181 -0.129977519972369 D127 -R133 -0.130221450137333 L112 -W165 -0.131000050268955 G152 -V163 -0.131356985230891 T147 -P174 -0.132866356461008 G105 -S154 -0.133157478109116 F118 -D127 -0.133178583532628 G105 -V163 -0.134782189065426 T121 -D127 -0.136201465270776 A108 -G156 -0.136292364564745 L79 -F87 -0.136362487459135 F169 -G176 -0.136435242639868 A119 -T147 -0.136688851396653 V168 -L175 -0.136773235231008 L120 -G148 -0.138044873157378 P174 -A180 -0.139444071100231 L112 -L151 -0.139657277878876 A123 -W181 -0.141082942622371 A126 -W181 -0.141872244810159 V93 -G105 -0.142386140731722 F169 -L177 -0.142516162820449 S132 -L140 -0.142590178800479 M138 -T147 -0.142874687327915 N172 -L178 -0.143979488408607 L92 -R107 -0.144667338677714 F118 -I171 -0.144839916986407 R107 -T147 -0.144916019292996 L175 -V183 -0.145141325091471 L92 -A106 -0.145193968368698 L124 -P174 -0.145302125777937 V109 -Q166 -0.145389501684551 G105 -G156 -0.145828519799126 V109 -G152 -0.14669996050725 D127 -L177 -0.146795747966262 A114 -L175 -0.147271254773266 V170 -G176 -0.147332950771936 G111 -S145 -0.147509969099684 G85 -S91 -0.147739911032925 V122 -A128 -0.147940450769624 S91 -G157 -0.148401761212361 V163 -F169 -0.148701502805504 T149 -N172 -0.148976476176487 L96 -R107 -0.1498114517067 A119 -I171 -0.150019445432099 L112 -A119 -0.150093132374023 G111 -S167 -0.150187414434923 I116 -S167 -0.150729836525721 A126 -L178 -0.150955666901396 T147 -N172 -0.150983379973922 P153 -M160 -0.151474965352907 F169 -P174 -0.151526793903402 A90 -F169 -0.152045462485781 L151 -P174 -0.15413132220219 G148 -V168 -0.156120514675937 V93 -R107 -0.156205185806906 A119 -F169 -0.156824621142925 A126 -A180 -0.157080170758018 A128 -L182 -0.158102902028681 I116 -L177 -0.158258343379864 A114 -V168 -0.158866846473673 G111 -G164 -0.159556915470151 L151 -G164 -0.159719142685237 L80 -A89 -0.161310590957698 S154 -Q166 -0.161473454618587 A128 -G135 -0.161903296356345 L120 -A126 -0.162181549295678 T88 -P153 -0.163055951451023 L81 -A90 -0.163707869094996 A106 -T149 -0.163783452376512 S91 -A106 -0.164568107769264 A90 -G152 -0.164586406638082 T149 -V170 -0.16469714665178 A123 -A180 -0.164911993454361 T150 -V170 -0.165005316225585 A123 -L140 -0.16515186547271 L112 -T147 -0.166902621374657 V109 -M144 -0.1671605629356 R107 -W165 -0.168266703241502 L151 -G156 -0.168316980050623 M117 -P174 -0.168513959382332 S154 -M160 -0.16937316249459 A123 -A142 -0.172679039891798 L155 -M160 -0.17278552932658 G111 -F169 -0.173425019583475 R107 -A146 -0.174441393534734 T121 -M144 -0.174493600057423 V109 -W165 -0.175349157409374 T149 -V173 -0.175842650770206 A126 -A134 -0.175950549548746 Q110 -M117 -0.176808049557397 V109 -G164 -0.177988247441836 A123 -A134 -0.178006212011917 F118 -L124 -0.178829756022775 F87 -A106 -0.178934078718317 A90 -A106 -0.180193011307227 F87 -P153 -0.180751762906597 F118 -W181 -0.180818550482476 L177 -Y184 -0.182286507057857 V125 -L178 -0.183157960550814 M144 -T149 -0.184938570304539 M117 -S145 -0.185207016975679 V93 -I104 -0.187883436329518 A106 -L151 -0.188585032290066 A126 -A137 -0.188780750509965 A119 -A142 -0.189796766617629 A97 -A106 -0.189847528024068 L124 -L141 -0.189969099065813 L151 -L158 -0.191671950461276 A106 -L158 -0.192148680929588 R107 -G156 -0.192693695418034 V93 -L158 -0.192753197444472 A108 -S145 -0.192906341151757 L178 -Y184 -0.193507635320624 A134 -G139 -0.193818757338579 L175 -Y184 -0.194434115532425 M117 -A146 -0.197907037598421 L175 -A180 -0.198306800290817 L120 -A137 -0.199339496417056 A90 -S154 -0.199876375718695 A128 -S136 -0.20116003943842 G176 -L182 -0.201195199544799 F87 -S154 -0.202707077606801 V173 -A180 -0.204255315735818 A119 -M144 -0.204421016652599 T147 -V168 -0.205143336270856 A108 -G164 -0.205568656407667 Q110 -I116 -0.205938179701226 L151 -W165 -0.211217996587507 V109 -L155 -0.211341929907573 L178 -V183 -0.212018210700965 T149 -Q166 -0.212158683912751 F118 -T143 -0.213340406091712 V168 -P174 -0.213476147921755 L151 -S167 -0.213510368295721 I86 -S91 -0.213575641448501 T150 -Q166 -0.214994700069701 L120 -L175 -0.215614888521563 A114 -S145 -0.215762723529211 A123 -Y184 -0.218186653275424 L92 -P153 -0.218330216542541 I116 -T149 -0.218823106436871 L92 -L159 -0.218900011075483 I82 -A89 -0.218987026938566 T121 -V183 -0.219126060516702 L159 -W165 -0.220292410183902 L92 -A97 -0.220474856568234 F118 -T147 -0.221705762742427 R107 -L151 -0.223541508060888 L112 -T149 -0.224436690075065 T121 -L182 -0.22463236981777 G139 -M144 -0.225254805393307 I82 -F87 -0.225395512487475 L120 -T147 -0.226968851461189 Q110 -L151 -0.227251522035154 A115 -S145 -0.227646933478558 L124 -W181 -0.228256693943969 T150 -V168 -0.229969415790872 G105 -L158 -0.233490172297849 M117 -T143 -0.233903537595329 G113 -T147 -0.237746260243966 V93 -L155 -0.238023077844129 T149 -S154 -0.239817480970866 L120 -D127 -0.241176587780267 W165 -N172 -0.244955092195322 A114 -A119 -0.247334096254863 A137 -A142 -0.247705322389298 A108 -A146 -0.249653332920202 I116 -P174 -0.249931204934849 F118 -M144 -0.251042963038901 F118 -G176 -0.252039200296514 A115 -F169 -0.254902777151006 M117 -V168 -0.255005559621596 L155 -W165 -0.255786337559782 N172 -W181 -0.257661983335301 T88 -L151 -0.25952993020318 A106 -G152 -0.259553709580204 L124 -G139 -0.259773331744814 T150 -P174 -0.262771574787198 A97 -I104 -0.26505586756811 A90 -G156 -0.265811347010035 T147 -V173 -0.266724435040008 A108 -P153 -0.267257523346131 G83 -A89 -0.267369958062049 L175 -W181 -0.268119574057581 S91 -S154 -0.270143305996116 A115 -L120 -0.270774138798895 L151 -V168 -0.271079408918928 S91 -T150 -0.271775147093767 T88 -T150 -0.272507467215553 V93 -M160 -0.272701712742645 L124 -A137 -0.273791691615425 A123 -L141 -0.27407329706176 A108 -L158 -0.275646379146034 I104 -G157 -0.275794878242458 A123 -L177 -0.275870383931767 A106 -P153 -0.275968472342988 L124 -G135 -0.278848550960048 V122 -M138 -0.279153292726685 I104 -P153 -0.283830834484356 G157 -W165 -0.287993389603015 A128 -A137 -0.288293381393816 A108 -V163 -0.288810063446576 L79 -G85 -0.292938373889744 M138 -M144 -0.292956784330047 A134 -L140 -0.293613232679435 L141 -T147 -0.300716456665639 A90 -L155 -0.300859831801753 A119 -L124 -0.302875913781081 L120 -A180 -0.302972129727424 L92 -L155 -0.303360629650511 L96 -A106 -0.303641378203785 V122 -V183 -0.305068912362451 T143 -G148 -0.306442535481185 L120 -L140 -0.309965167843304 I116 -M144 -0.310093976827227 A106 -M160 -0.311808523563299 L120 -T143 -0.311943970501902 S167 -V173 -0.313353128505331 I84 -A90 -0.314365301757738 G157 -G164 -0.314799435478826 G152 -L158 -0.315649548403091 G135 -L140 -0.3165413867097 A115 -T149 -0.317797292668136 T121 -A126 -0.318067509615355 D127 -A134 -0.320516683529208 L120 -G139 -0.324719333581969 L79 -I86 -0.326105478128048 V122 -A180 -0.328781468232545 M117 -I171 -0.329646528210095 L120 -W181 -0.332344400857853 V125 -V183 -0.332945180217113 S154 -L159 -0.333640067522835 I171 -L177 -0.33423330856892 V173 -N179 -0.338081051780381 I86 -T150 -0.338612718028886 S136 -L141 -0.339285150872811 L151 -G157 -0.339685401848292 V109 -V168 -0.341308118112287 L177 -V183 -0.344073017036624 M117 -V122 -0.344155588295747 L80 -G85 -0.345760806048011 A119 -V125 -0.348241586891312 G111 -T147 -0.350317716486478 L112 -S167 -0.352953757899967 G83 -T88 -0.355663290924391 A115 -G148 -0.360266571677885 L96 -I104 -0.36272223472342 Q110 -G148 -0.363381754844924 V125 -M138 -0.363603638915754 L177 -L182 -0.365222093312602 F118 -L178 -0.365371491104479 V125 -A134 -0.369578966135966 A119 -V173 -0.37168426454749 A115 -T143 -0.375477845127395 A128 -A134 -0.380162789042967 L112 -I171 -0.382121157991638 L112 -F169 -0.384837388852881 W165 -V170 -0.385043945413589 L79 -I84 -0.386753544410503 L81 -I86 -0.387009155298497 V170 -L175 -0.393394889927046 L80 -I86 -0.396692679448031 A126 -M138 -0.40802382572145 V125 -L177 -0.408544563370034 G152 -G157 -0.413846302118191 I82 -T88 -0.416296868300019 I86 -L151 -0.418182822639059 L120 -V125 -0.4214483879967 G85 -A90 -0.42642722836262 Q110 -F169 -0.432268179390716 I84 -A89 -0.43322937258937 T121 -T143 -0.436918326374938 A89 -G152 -0.437984851195409 V173 -L178 -0.451451382205086 P153 -L159 -0.453041549150146 I116 -V170 -0.466313682039854 A115 -A146 -0.47414037028615 R107 -P153 -0.54069113113854 S91 -G152 -0.668529673438709