[Mon Aug 29 17:01:28 2016] >Input file: TMQ4C1M8M3G.pdb >TM segments: 159-192_ 247-315_ 417-426_ 482-494_ 498-507_ 509-521 MAIDEN score = -36.7881 Below is the ranking list of the residue pairs and their related pseudo-energy (the lower, the better). This includes inter-chain residue pairs. The maximum (least favorable) pairwise energy value has been set to 10. See the MAIDEN software article: Postic,G., Ghouzam,Y. and Gelly,J.C. (2015) Biochimie, 115, 155–161. ----------- ---------------- Calpha pair Empirical energy ----------- ---------------- I267 -I272 1.7147185482593 M171 -I248 1.58469304656078 V419 -L500 1.3049340562464 I267 -I274 1.18577031323215 L163 -L259 1.07356951605615 L187 -V306 0.992200634722929 Q421 -L500 0.959054451529603 V175 -I248 0.917553784665325 V419 -D502 0.84832941571758 L187 -Q303 0.825783442092796 A266 -I271 0.809928566858293 P420 -L500 0.779123715560111 L187 -D309 0.752331530397598 Q483 -L504 0.75159939522478 M171 -L251 0.727554314624497 L160 -L259 0.721817683136197 I248 -G295 0.68325049977276 P420 -A503 0.682308208134633 L163 -M258 0.671966973318507 I267 -F277 0.659464867665753 I272 -F277 0.642985572169831 Y418 -A490 0.636540546241164 L491 -Q521 0.634982057308488 V167 -L251 0.62565564163989 A417 -L498 0.62425737146325 A417 -D494 0.614167230055532 L182 -Q303 0.608111980159074 F424 -A486 0.607586751286637 V419 -L487 0.585340979555422 I267 -S273 0.584028512391585 V167 -I254 0.579432503163457 I184 -V306 0.576913923017481 A164 -L256 0.575127925318097 Y253 -V288 0.570863370586843 P420 -D502 0.558640141746348 Q183 -Q303 0.547622866158014 L256 -V288 0.543880140698906 L160 -F262 0.537749363595709 Y418 -L498 0.515834743155397 Y418 -L500 0.493662040726997 D276 -L281 0.486567359876702 L170 -L251 0.481027010132276 Y418 -D501 0.480982532011681 Q185 -Y301 0.473960867094204 L256 -V284 0.473039704452147 L487 -A503 0.470235818100982 R484 -V507 0.445208368605599 L425 -R482 0.441488865207594 L187 -R310 0.434031887942938 S264 -F277 0.43132089541648 V165 -S255 0.429939513289946 V419 -A490 0.429837369402699 L163 -F262 0.427930794570951 R482 -L487 0.425556608343644 Y168 -S255 0.417968079350019 Q483 -V507 0.415577717013108 S161 -L259 0.404685046155785 V419 -R489 0.396904821342429 Q186 -Q303 0.393263600621006 A164 -M258 0.390147944989415 Y168 -S252 0.388408802874573 E249 -P290 0.384179249766816 K180 -Q188 0.368954021615951 A174 -I248 0.367812534152213 S255 -P290 0.36285381216931 Q421 -D502 0.362386761674805 A174 -L247 0.355752748609382 K180 -A300 0.353251510842347 Q483 -A503 0.352423194844412 L182 -T299 0.347285142844614 A166 -S255 0.340721740658736 L504 -A512 0.336429920660013 Q183 -E191 0.335220273014042 L259 -S264 0.325178469146223 G263 -F277 0.318098746616429 K510 -S518 0.318035467306879 Q176 -Y301 0.315555898729131 G270 -G275 0.314577264092012 A417 -M493 0.313231047382103 S179 -T299 0.311392780003608 T485 -T511 0.309546402323749 T291 -T299 0.307912108614703 Y418 -V499 0.307312117875991 S252 -T291 0.305887580625054 Q190 -E305 0.30135632542687 A490 -S518 0.299250703090426 R484 -L504 0.296723237927445 S179 -I298 0.296625226567098 I274 -A279 0.296474638245619 S264 -G275 0.293877331918439 A490 -L498 0.292008946692699 V284 -F289 0.286045528466481 V419 -L498 0.281282884727384 A488 -A503 0.280220024174715 M171 -S252 0.278252661301385 L425 -A486 0.277803157181012 E249 -A292 0.276362456625216 D276 -V284 0.276284692021256 Q185 -E305 0.273760454205019 S423 -R482 0.270684990120395 S505 -K510 0.26758333540826 S179 -G304 0.2650698098233 V419 -V499 0.261439832711655 T268 -S273 0.261427714120154 Y418 -R489 0.258258457536575 Q188 -E305 0.257259267056609 D309 -F315 0.252539489336824 L187 -S307 0.24895300332827 E191 -Q303 0.248331904315704 P169 -Y253 0.246357346185228 K192 -S307 0.245987037380856 P420 -L498 0.244564612178597 K180 -Q302 0.244472798734322 L256 -T291 0.242016939328862 K180 -S307 0.236671129478012 Y418 -A488 0.234099471040079 F178 -Q186 0.233886509665449 G270 -F277 0.23219934013883 S255 -V288 0.227182364412163 S161 -S265 0.226360993284844 F178 -G295 0.22591891160934 F426 -A486 0.225460982445322 G250 -V288 0.221732933642341 R159 -M258 0.221087064904001 Q421 -D501 0.220112871259694 A503 -S518 0.218866349435696 I184 -G304 0.215983198261139 A164 -L259 0.21593918349835 Q176 -Q303 0.215417889346781 E249 -T299 0.214746018035304 G250 -L257 0.213876219284403 S161 -A261 0.213474006167022 L163 -G263 0.213009762843454 Q190 -S307 0.212594436957737 Q269 -F277 0.212172710818526 V419 -S505 0.211369570922188 S252 -V284 0.207951311210484 K180 -D309 0.207203297715712 K180 -E305 0.206879458708388 F277 -V284 0.206298582991069 A417 -D501 0.205422225331236 P420 -S506 0.204937306828435 Q176 -Q185 0.204149703047483 T268 -G275 0.203719229308336 M493 -L500 0.202825935808988 F178 -E249 0.20194058104119 L160 -G263 0.199846431019477 T297 -E305 0.199314495486016 S255 -S264 0.198824127867884 P169 -G295 0.196671191886563 Q483 -S506 0.195654164925669 S161 -Y168 0.192926993319803 V175 -I298 0.192659448231991 A417 -R489 0.190727051924571 V167 -S252 0.189954570516698 L260 -S265 0.189492212950819 D422 -R482 0.185807115337894 L504 -N509 0.185576432166302 L256 -P290 0.184907066778106 A266 -I272 0.184714765668058 Q421 -T485 0.181998896777969 M171 -L256 0.181107724382105 L504 -K517 0.18079517920831 I272 -A279 0.180661182320676 Y168 -F289 0.179525933675398 I293 -A300 0.179310185674438 L160 -G270 0.178886705404792 L163 -S255 0.177103039639148 R482 -D501 0.176924769555198 L283 -P290 0.175662587644006 P420 -R489 0.174108160074021 G263 -A279 0.172975190049326 V167 -L256 0.172381423611803 S273 -L281 0.17230467301565 S179 -G295 0.172198424045579 S255 -L280 0.171783855907727 V175 -S252 0.170281632066125 G275 -L283 0.170099559289707 D422 -R489 0.169924974394818 L187 -K192 0.169687420794075 R489 -D501 0.169232371729882 S255 -R286 0.168026030466962 E191 -A313 0.167885013714418 R484 -Q521 0.167598100447658 E191 -V311 0.166569454867268 L170 -G295 0.16589834434618 T268 -I278 0.164938086048944 D422 -V499 0.164318659976206 K192 -R310 0.163924682891194 Y168 -V284 0.163345273368549 A261 -G270 0.162997576496726 Q185 -G304 0.161586655370902 T268 -D276 0.161417124966082 L163 -S252 0.16098307467032 A174 -T291 0.160240790771209 A486 -S506 0.160232712826227 D501 -V507 0.159416443350556 A417 -L500 0.159171460065645 R484 -K510 0.158102219972811 I173 -I248 0.156985339420456 S179 -S307 0.156721795275109 L516 -Q521 0.15593941384392 Q183 -Q302 0.155248930486334 A164 -R286 0.152208526524726 A490 -S520 0.15137641380719 A503 -K517 0.15039426034906 S252 -A292 0.150223584251913 Y418 -R484 0.150204361425351 A164 -I282 0.149922570353955 S423 -Q483 0.149535652383369 N514 -L519 0.149172464334477 L487 -S520 0.149091563736154 V167 -A261 0.14698937862797 L260 -L281 0.14655007975501 Q185 -A300 0.145842008370995 D502 -A512 0.145690874660353 V308 -A313 0.145047960715221 L163 -Y253 0.144305004231701 R489 -A503 0.143354204476213 L247 -I293 0.14246068052635 V419 -R482 0.141863215804141 A166 -F262 0.141313719237699 I254 -E285 0.141299264289272 L172 -I254 0.141262642808027 A166 -T291 0.139442446473135 A417 -S423 0.13864403082512 P420 -R484 0.137669561394036 A486 -D501 0.13760989814134 K181 -A300 0.136849681276502 L172 -G250 0.136581457661661 I184 -K192 0.135132646877413 G263 -G275 0.134645496312867 M493 -L519 0.134490244835065 Y301 -D309 0.134203068252165 L182 -L247 0.13396357218284 A503 -N509 0.13370816921395 F178 -Q303 0.133232322745374 K181 -I189 0.133134005286973 D422 -T485 0.132958098298487 A488 -N514 0.132417222768099 S505 -T511 0.13187929075843 A300 -E305 0.131506310439895 E249 -T297 0.131341505030753 Q176 -G295 0.131209580030772 I173 -T291 0.131030523443602 Y253 -A261 0.129866641384478 G250 -L256 0.129682479687762 A486 -D502 0.128858601994446 Y418 -L519 0.127176554293404 F262 -S273 0.12693115145333 R489 -Q521 0.126622486579469 A164 -A266 0.12635400398 I189 -E305 0.126328740339648 Y168 -L257 0.126000202487796 S161 -S252 0.125432198306862 Y418 -L504 0.125017978872655 S252 -A261 0.124891682016846 I278 -E285 0.12461262840532 P169 -G250 0.124481319502718 I173 -G250 0.124282073944272 G263 -I282 0.123943116458037 L172 -I293 0.123889487463565 I173 -K180 0.12331435784184 A292 -A300 0.12318553592626 S179 -Q188 0.122172654982793 S161 -A279 0.121892819493912 L487 -K517 0.121729262492551 R159 -A261 0.121138316587357 K510 -I515 0.121112527412185 L504 -T511 0.121035720661773 L251 -L259 0.119884322414211 F426 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0.110476919349262 S423 -L504 0.110305945647476 V499 -L519 0.109789222093781 F424 -R482 0.109083518571956 A488 -S506 0.108919796542055 R159 -I271 0.107714924002604 S161 -L257 0.107629194010546 L259 -V288 0.10761401425125 A166 -G263 0.106390760008932 A300 -V308 0.105961364474838 L160 -L287 0.105462423471579 G250 -I293 0.105051914370435 A279 -R286 0.104806795219966 L162 -V167 0.104238234847003 L163 -V288 0.104157538873998 D502 -L516 0.104142554587789 S161 -L260 0.104120876807551 V167 -L287 0.103554384069021 K180 -Q185 0.103467832368622 S161 -A266 0.103331566956255 V167 -L260 0.102961292145861 Q303 -V311 0.102079616027482 V419 -S506 0.102050865148563 G250 -G295 0.102018818787484 L172 -S255 0.101380418221886 T485 -V507 0.101336684195366 A279 -E285 0.100972555736151 T299 -S307 0.100376534794502 G250 -T291 0.100075848730635 I173 -E249 0.0997963970877356 A166 -A261 0.0995907311893887 K181 -D309 0.0992835892759794 F296 -Q303 0.0991951969586928 Y418 -Q483 0.0991602588552958 L251 -L287 0.0990781751723659 F262 -A279 0.0989778708427744 A261 -I278 0.0987184917079098 I189 -Q302 0.0985199775591417 D422 -L487 0.0984837682250139 V167 -L247 0.0983649398317676 A174 -L294 0.0980670786210847 L163 -I272 0.0979906398053068 Q421 -L504 0.0977389174083778 M493 -S518 0.0971770222593031 S423 -L500 0.0967572920041513 K192 -V306 0.0966634038739089 A417 -L491 0.0963897945130192 L162 -L283 0.096255703702985 L260 -Q269 0.096229913612613 L162 -P169 0.0960253887112262 A261 -L280 0.0956307852969011 A488 -L504 0.095383440231557 A266 -G275 0.0952023758293553 L162 -L170 0.0950441210241855 A261 -S273 0.0949250270184134 L247 -L294 0.0949127002758554 F426 -A488 0.0946795877699653 F178 -Q302 0.0946609042474575 M258 -L287 0.0943786341137822 S161 -D276 0.0943139059433085 I271 -I278 0.0942000480518286 Q188 -G304 0.0936184841353507 L170 -I298 0.0932505731362752 Y253 -R286 0.0931524396482635 Q183 -R310 0.0927895860513974 L281 -V288 0.0927407255795765 M171 -L287 0.0924024685094897 L170 -L257 0.0923567965055949 T291 -Y301 0.0922813854921021 S252 -V288 0.0921041670963394 L162 -L257 0.0912417283717675 V175 -F296 0.0911406812084739 Y253 -L287 0.0911352985287355 T485 -M493 0.0909204359329298 A417 -T485 0.0908976100863148 A486 -L519 0.0906958663993513 A164 -L251 0.0906502637933406 S423 -A488 0.0906501552373067 F289 -F296 0.0904234430907791 I274 -L283 0.0903138970824825 L163 -A279 0.0902661281594419 V165 -A292 0.0901912050834648 A486 -L498 0.0901218253503497 V306 -I314 0.0899838956905815 I298 -V306 0.089957715454071 L170 -M258 0.089685152078415 L257 -L283 0.0892316152277017 V165 -L260 0.08918318774061 V175 -T291 0.0890187175045067 T485 -N514 0.0886279837723896 L160 -S255 0.0885645927104612 Y418 -S505 0.0884736675396747 K181 -T299 0.0883078368815258 L259 -F277 0.0881466614115571 S179 -L294 0.0879632585649066 I248 -L287 0.0878084842575194 K180 -G304 0.0877773774282666 P169 -A292 0.0876817452568748 L172 -Q302 0.0876107114610289 L500 -S520 0.0870672049293706 L492 -I515 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0.0696677404842347 L162 -L287 0.0695349789570061 Q421 -R489 0.0692667379526158 V175 -T297 0.0690699023242626 M171 -M258 0.0690498252809909 E191 -E305 0.0689523687715522 L251 -L294 0.0688234986634706 Q188 -V308 0.0686954677886352 L182 -E305 0.068391699635399 L425 -Q483 0.0683017168566682 V165 -T291 0.0680550426732788 Q190 -V306 0.0679570030344721 L162 -L281 0.0678351074010273 Q186 -V311 0.0675678221155558 R482 -T511 0.0674762432466614 F424 -A490 0.0672642640592407 L160 -A279 0.0666520250650637 R159 -L280 0.0662437659635762 A490 -L504 0.0661254842414401 L163 -I267 0.065901606680725 A279 -L287 0.0658996461727872 M171 -P290 0.0655113408121828 V165 -G263 0.0653321924870056 G263 -I278 0.065325526836185 L187 -A300 0.0653160509159609 S179 -I248 0.0652298185218387 L251 -I293 0.0650267475563151 L280 -F289 0.0647975026464147 A174 -Y253 0.0646120864913926 A174 -L251 0.0642077589142218 Y168 -L251 0.0641028599698013 V419 -A503 0.0640693448426002 D422 -V507 0.0637646802170542 L172 -L287 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