Tubulin alpha-1B chain (TUBA1B)

The protein contains 451 amino acids for an estimated molecular weight of 50152 Da.

 

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (updated: April 1, 2015)

Protein identification was indicated in the following studies:

  1. Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
  2. Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
  3. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
  4. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
  5. Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

Interpro domains
Total structural coverage: 100%
Model score: 100

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The reference OMIM entry for this protein is 602530

Tubulin, alpha-1b; tuba1b
Tubulin, alpha, ubiquitous
K-alpha-1

GENE FAMILY

See 602529 for general information about the alpha-tubulin gene family.

NOMENCLATURE

See Khodiyar et al. (2007) for a revised nomenclature of the alpha-tubulin gene family.

CLONING

The human counterpart of the mouse tubulin gene M-alpha-2 is the k-alpha-1 gene, cloned from a human keratinocyte cDNA library by Cowan et al. (1983). The k-alpha-1 gene encodes a predicted 451-amino acid protein that differs from the b-alpha-1 protein by only one amino acid. By Northern blotting, k-alpha-1 mRNA was expressed in all tissues tested. By Northern blot analysis and in situ hybridization, Miller et al. (1987) found that the rat homolog of k-alpha-1, which they called T26, is expressed constitutively at a low level in most or all neural cell types throughout development, with some enrichment in proliferative zones.

MAPPING

Khodiyar et al. (2007) stated that the TUBA1B gene maps to human chromosome 12q13.12 and mouse chromosome 15F1. ... More on the omim web site

Subscribe to this protein entry history

May 13, 2019: Protein entry updated
Automatic update: model status changed

Nov. 17, 2018: Protein entry updated
Automatic update: model status changed

Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated

Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated

June 20, 2017: Protein entry updated
Automatic update: comparative model was added.

March 16, 2016: Protein entry updated
Automatic update: OMIM entry 602530 was added.

Jan. 25, 2016: Protein entry updated
Automatic update: model status changed