RELT-like protein 1 (RELL1)

The protein contains 271 amino acids for an estimated molecular weight of 29340 Da.

 

Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). (updated: Nov. 7, 2018)

Protein identification was indicated in the following studies:

  1. Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
  2. Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
  3. Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
  4. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
  5. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
  6. Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt, is predicted to be membranous by TOPCONS.


Interpro domains
Total structural coverage: 91%
Model score: 0
No model available.

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The reference OMIM entry for this protein is 611212

Relt-like 1; rell1

CLONING

By EST database analysis to search for sequences with similarity to RELT (611211), Cusick et al. (2006) cloned full-length RELL1 and RELL2 (611213). The predicted RELL1 sequence contains a transmembrane domain but lacks extracellular cysteine-rich domains. RELL1 shares 32% and 40% amino acid identity with RELT and RELL2, respectively. Northern blot analysis detected an approximately 4-kb transcript in all human tissues examined with highest expression in placenta, spleen, skeletal muscle, and testis. Immunofluorescent confocal microscopy localized RELL1 to the plasma membrane in COS-7 cells and colocalized RELL1 with RELL2 and RELT.

GENE FUNCTION

Using yeast 2-hybrid analysis with the RELL1 intracellular domain as bait to screen a B-cell library, Cusick et al. (2006) identified the serine-threonine kinase OSR1 (OXSR1; 604046) as a RELL1-binding protein. Coimmunoprecipitation studies showed that RELL1 interacted with RELL2, RELT, and OSR1. By in vitro kinase assay, Cusick et al. (2006) showed that RELL1, RELL2, and RELT were phosphorylated by OSR1.

MAPPING

The International Radiation Hybrid Mapping Consortium mapped the RELL1 gene to chromosome 4 (TMAP STS-H93265). ... More on the omim web site

Subscribe to this protein entry history

Nov. 16, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.

Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated

Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated

March 25, 2017: Additional information
No protein expression data in P. Mayeux work for RELL1

March 16, 2016: Protein entry updated
Automatic update: OMIM entry 611212 was added.