Ras-related protein Rab-2B (RAB2B)
The protein contains 216 amino acids for an estimated molecular weight of 24214 Da.
Required for protein transport from the endoplasmic reticulum to the Golgi complex. (updated: April 1, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt.
(right-click above to access to more options from the contextual menu)
| Variant | Description |
|---|---|
| dbSNP:rs17106411 |
Biological Process
Intracellular protein transport
Metabolic process
Positive regulation of exocytosis
Protein transport
Rab protein signal transduction
Vesicle-mediated transport
The reference OMIM entry for this protein is 607466
Ras-associated protein rab2b; rab2b
DESCRIPTION
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see 179508.CLONING
During a large-scale sequencing analysis of human cDNA libraries, Ni et al. (2002) cloned a full-length cDNA of a novel RAB gene, designated RAB2B. The deduced 216-amino acid RAB2B protein shares 82% and 83% sequence identity with human RAB2 (179509) and mouse Rab2, respectively. RT-PCR analysis revealed expression of RAB2B in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and at lower levels in placenta. No transcript was detected in heart, brain, spleen, testis, ovary, small intestine, and leukocyte. Overexpression was observed in a colon adenocarcinoma.GENE STRUCTURE
Ni et al. (2002) determined that the RAB2B gene contains 9 exons.MAPPING
By sequence analysis, Ni et al. (2002) mapped the RAB2B gene to chromosome 14q11.1-q11.2. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for RAB2B
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 607466 was added.