Protein ZNRD2 (SSSCA1)

The protein contains 199 amino acids for an estimated molecular weight of 21474 Da.

 

Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies. (updated: June 5, 2019)

Protein identification was indicated in the following studies:

  1. Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
  2. Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
  3. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

Interpro domains
Total structural coverage: 100%
Model score: 34

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VariantDescription
dbSNP:rs35971725

Cellular Component

Molecular Function

Identical protein binding GO Logo

The reference OMIM entry for this protein is 606044

Sjogren syndrome/scleroderma autoantigen 1; sssca1
Centromeric autoantigen, 27-kd

CLONING

The centromere plays an essential role in the pairing and partitioning of replicated chromosomes in mitosis and meiosis and is recognized by anticentromere antibodies in patients with autoimmune disorders. By immunoscreening a cDNA library with serum from a Sjogren syndrome (270150) patient with anticentromere antibodies, Muro et al. (1998) isolated a cDNA encoding SSSCA1, which they referred to as p27 due to its molecular mass in Western blot analysis. The deduced 199-amino acid, leucine-rich protein has an N terminus with many charged residues and a potential phosphorylation site; 2 short proline-rich stretches; and a potential C-terminal phosphorylation site. Immunofluorescence analysis failed to demonstrate centromeric or other staining. Immunoblot analysis with recombinant SSSCA1 determined that approximately 2% of patients with anticentromere antibodies had anti-SSSCA1 antibodies, while less than 1% of autoimmune patients without anticentromere antibodies had anti-SSSCA1 antibodies. All 5 seropositive patients had a diagnosis of scleroderma (see 181750) or Sjogren syndrome with internal organ involvement. ... More on the omim web site

Subscribe to this protein entry history

June 7, 2019: Protein entry updated
Automatic update: Entry updated from uniprot information.

Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated

Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated

June 20, 2017: Protein entry updated
Automatic update: comparative model was added.

March 16, 2016: Protein entry updated
Automatic update: OMIM entry 606044 was added.

Feb. 25, 2016: Protein entry updated
Automatic update: model status changed

Feb. 24, 2016: Protein entry updated
Automatic update: model status changed

Jan. 25, 2016: Protein entry updated
Automatic update: model status changed