Glia maturation factor gamma (GMFG)
The protein contains 142 amino acids for an estimated molecular weight of 16801 Da.
No function (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs36110047 | |
| dbSNP:rs34035414 |
Biological Process
Actin filament debranching
Negative regulation of Arp2/3 complex-mediated actin nucleation
Negative regulation of protein kinase activity
Neutrophil degranulation
Positive regulation of catalytic activity
Protein phosphorylation
Regulation of actin cytoskeleton reorganization
The reference OMIM entry for this protein is 604104
Glia maturation factor, gamma; gmfg
Gmf-gamma
CLONING
Glia maturation factor-beta (GMFB; 601713) is a 17-kD protein that was initially identified as a growth and differentiation factor acting on neurons and glia in vertebrate brain. By searching an EST database for sequences related to GMFB, Asai et al. (1998) identified cDNAs encoding a protein that they designated GMF-gamma. The predicted 142-amino acid protein is 82% identical to GMF-beta and contains the 3 cysteine residues considered to be crucial for GMF-beta biologic activity. Northern blot analysis revealed that the GMF-gamma gene was expressed as a 0.9-kb mRNA predominantly in lung, heart, and placenta. An additional low-abundance 1.2-kb transcript was detected in heart and skeletal muscle. Independently, Mao et al. (1998) identified a cDNA corresponding to GMF-gamma, which they referred to as a GMF-beta homolog, among a collection of cDNAs expressed in hematopoietic stem/progenitor cells.MAPPING
Peters et al. (1999) stated that the GMFG gene had been mapped to 19q13.2.MOLECULAR GENETICS
- Exclusion Studies Given the putative role of GMF-gamma in cell differentiation and proliferation and its map location in a region that is frequently deleted in human malignant gliomas, Peters et al. (1999) considered it a candidate for a glioma tumor suppressor gene. Peters et al. (1999) determined the genomic structure of the human GMFG gene and performed mutation screening in a series of 41 gliomas with and without allelic loss of chromosome 19q. No mutations were detected. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
June 20, 2017: Protein entry updated
Automatic update: comparative model was added.
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 604104 was added.
Jan. 28, 2016: Protein entry updated
Automatic update: model status changed
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed