Protein SGT1 homolog (SUGT1)
The protein contains 365 amino acids for an estimated molecular weight of 41024 Da.
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. (updated: Nov. 22, 2017)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Biological Process
Innate immune response
Mitotic cell cycle
Mitotic nuclear division
Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
Positive regulation by host of symbiont catalytic activity
Protein stabilization
Purinergic nucleotide receptor signaling pathway
Regulation of protein stability
Cellular Component
Cytoplasm
Cytosol
Kinetochore
Nucleus
Protein complex
Protein-containing complex
Ubiquitin ligase complex
The reference OMIM entry for this protein is 604098
Suppressor of g2 allele of skp1, s. cerevisiae, homolog of; sugt1
Sgt1
CLONING
Kitagawa et al. (1999) identified the S. cerevisiae SGT1 (suppressor of G2 allele of SKP1) gene, which, like SKP1 (see 601434), is required for both the G1/S and G2/M transitions in the cell cycle. The SGT1 protein physically associates with the SKP1 protein and the SCF (SKP1/Cdc53/F box protein) ubiquitin ligase complex (see 603134) and is required for kinetochore function, where it serves as an activator of the Ctf13 protein. Kitagawa et al. (1999) also cloned the human homolog of the yeast SGT1 gene. The yeast and human SGT1 proteins share 26% identity and 30% similarity. Human SGT1 could perform the essential functions of SGT1 in budding yeast, indicating that SGT1 function is conserved throughout eukaryotes.MAPPING
Gross (2012) mapped the SUGT1 gene to chromosome 13q14.3 based on an alignment of the SUGT1 sequence (GenBank GENBANK AF132856) with the genomic sequence (GRCh37). ... More on the omim web site
Feb. 10, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 604098 was added.
Feb. 24, 2016: Protein entry updated
Automatic update: model status changed