Unconventional myosin-Ib (MYO1B)

The protein contains 1136 amino acids for an estimated molecular weight of 131985 Da.

 

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. (updated: Oct. 10, 2018)

Protein identification was indicated in the following studies:

  1. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

This protein is annotated as membranous in Gene Ontology.


Interpro domains
Total structural coverage: 0%
Model score: 34

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VariantDescription
a colorectal cancer sample; somatic mutation
a colorectal cancer sample; somatic mutation
a melanoma patient

No binding partner found

The reference OMIM entry for this protein is 606537

Myosin ib; myo1b

Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. For further background information on myosins, see MYO1A (601478).

CLONING

By RT-PCR analysis of an intestinal epithelial cell line and a liver cDNA library, Bement et al. (1994) obtained multiple cDNAs encoding unconventional myosins, among them a liver cDNA encoding MYO1B. RNase protection analysis detected expression of MYO1B in the intestinal epithelial cell line.

MAPPING

The International Radiation Hybrid Mapping Consortium mapped the MYO1B gene to chromosome 2 (TMAP stSG32097). ... More on the omim web site

Subscribe to this protein entry history

Feb. 23, 2019: Protein entry updated
Automatic update: model status changed

Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 606537 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).