Keratin, type I cytoskeletal 13 (KRT13)
The protein contains 458 amino acids for an estimated molecular weight of 49588 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs12150581 | |
| WSN2 | |
| WSN2 | |
| WSN2 | |
| WSN2 | |
| WSN2 | |
| dbSNP:rs760134 | |
| dbSNP:rs9891361 | |
| dbSNP:rs4796697 |
No binding partner found
Cellular Component
Cytosol
Extracellular exosome
Intermediate filament cytoskeleton
Keratin filament
Nucleus
The reference OMIM entry for this protein is 148065
Keratin 13, type i; krt13
K13
Ka13
Cytokeratin 13; ck13
DESCRIPTION
Keratin intermediate filaments (KIFs) are assembled from heterodimeric subunits comprised of a type I and a type II protein. Keratin-13 (KRT13) is a member of the type I (acidic) subfamily of genes characteristic of the internal stratified epithelia (Romano et al., 1991).MAPPING
By PCR amplification with cytokeratin 13-specific DNA antimers of a human-hamster somatic cell hybrid DNA panel, Romano et al. (1991) mapped the KRT13 gene to chromosome 17. By means of in situ hybridization, they determined the subchromosomal localization to be 17q12-q22. They further analyzed this region by pulsed field gel electrophoresis and demonstrated that the KRT13 gene is in the same large DNA fragment as the KRT10 (148080) and KRT15 (148030) genes. Further experiments performed with conventional agarose gel electrophoresis showed that the KRT10 and KRT13 genes are located in the same 14-kb fragment. A correlation of assignments of the 3 genes makes 17q21-q22 the likely location of the cluster. Romano et al. (1992) gave the location as 17q12-q21.2. Ceratto et al. (1997) isolated and analyzed a YAC clone that mapped to 17q12-q21 by fluorescence in situ hybridization. By Southern analysis and pulsed field gel electrophoresis they concluded that KRT13, KRT14 (148066), KRT15, KRT16, and the linked type I genes KRT17 (148069) and KRT19 (148020), are contained in less than 150 kb of genomic DNA.MOLECULAR GENETICS
In affected members of a multigenerational Italian family segregating white sponge nevus-2 (WSN2; 615785), Richard et al. (1995) identified heterozygosity for a missense mutation in the KRT13 gene (148065.0001). In a Japanese mother and 2 children with WSN2, who were negative for mutation in the KRT4 gene (123940), Shibuya et al. (2003) identified heterozygosity for a missense mutation in the KRT13 gene (L111P; 148065.0002). ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 148065 was added.
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).