Protein S100-P (S100P)
The protein contains 95 amino acids for an estimated molecular weight of 10400 Da.
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in UniProt.
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Biological Process
Endothelial cell migration
Neutrophil degranulation
Response to organic substance
The reference OMIM entry for this protein is 600614
S100 calcium-binding protein p; s100p
DESCRIPTION
Members of the S100 family, such as S100P, belong to the superfamily of Ca(2+)-binding proteins containing EF-hand motifs. S100 proteins show cell type-specific expression patterns and are thought to be involved in cytoplasmic Ca(2+) control (Becker et al., 1992).CLONING
S100P was cloned and characterized by Becker et al. (1992).GENE FUNCTION
Using Far Western screening, in vitro binding assays, and coimmunoprecipitation analysis, Dowen et al. (2005) found that S100P interacted with S100PBP (611889). Binding of S100P to S100PBP in vitro was dependent on Ca(2+) and Mg(2+). GFP-tagged S100PBP localized to nuclei of transfected HeLa cells, whereas immunocytochemical analysis localized endogenous S100P to both nuclei and cytoplasm in HeLa cells, suggesting that S100P and S100PBP interact in the nucleus. Quantitative PCR revealed upregulated S100P and S100PBP expression in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma samples, and S100PBP expression was also upregulated in chronic pancreatitis samples. Both S100P and S100PBP showed upregulated expression in pancreatic cancer cell lines, including the HPDE cell line derived from normal pancreatic duct cells. In situ hybridization of normal pancreas detected S100PBP mRNA in islet cells and at low levels in some acinar cells, but not in ductal cells. However, in pancreatic ductal adenocarcinoma samples, S100PBP mRNA was detected in malignant ductal epithelial cells, as well as in islet cells and acinar cells. S100P showed a pattern of expression similar to that of S100PBP in both healthy pancreas and pancreatic cancer. Immunohistochemical analysis showed that S100P expression correlated significantly with increasing grade of pancreatic intraepithelial neoplasia. Dowen et al. (2005) concluded that S100P and S100PBP may be involved in early pancreatic cancer development.MAPPING
Using isotopic in situ hybridization, Schafer et al. (1995) mapped the S100P gene to chromosome 4p16. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 600614 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).