High affinity cationic amino acid transporter 1 (SLC7A1)

The protein contains 629 amino acids for an estimated molecular weight of 67638 Da.

 

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. (updated: Oct. 10, 2018)

Protein identification was indicated in the following studies:

  1. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
  2. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
  3. Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt, is predicted to be membranous by TOPCONS.


Interpro domains
Total structural coverage: 0%
Model score: 39

(right-click above to access to more options from the contextual menu)

No binding partner found

The reference OMIM entry for this protein is 104615

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; slc7a1
Amino acid transporter, cationic 1; atrc1
Cationic amino acid transporter 1; cat1

CLONING

Susceptibility to murine ecotropic retroviruses is attributed to the binding of the virus envelope to the membrane receptor encoded by the Rec1 gene. Rec1 was identified as the principal transporter of the cationic amino acids arginine, lysine, and ornithine in mouse cells (Kim et al., 1991). Albritton et al. (1992) a human cDNA with homology to mouse Rec1.

GENE FUNCTION

Bhattacharyya et al. (2006) found that endogenous CAT1 mRNA was translationally repressed by miR122 (MIR122A; 609582) in Huh7 human hepatoma cells. CAT1 mRNA and reporters bearing its 3-prime UTR could be relieved from miR122-mediated repression by subjecting Huh7 cells to different stress conditions. This derepression was accompanied by release of CAT1 mRNA from cytoplasmic processing bodies and its entry into polysomes, and this process involved binding of HuR (ELAVL1; 603466) to the 3-prime UTR of CAT1.

MAPPING

Oie et al. (1978), Ruddle et al. (1978), and Kozak et al. (1990) mapped the Rec1 gene to mouse chromosome 5 by analysis of murine-hamster somatic cell hybrids. Using a human cDNA obtained by homology to Rec1, Albritton et al. (1992) determined the location of the human cationic amino acid transporter by somatic cell genetics, in situ hybridization, and RFLP linkage analysis. The studies indicated that ATRC1 is located at chromosome 13q12-q14, closely linked to ATP1AL1 (182360). The CEPH consortium linkage map of chromosome 13 published by Bowcock et al. (1993) showed ATRC1 to be distal to ATP1AL1. ... More on the omim web site

Subscribe to this protein entry history

June 30, 2020: Protein entry updated
Automatic update: OMIM entry 104615 was added.

Feb. 23, 2019: Protein entry updated
Automatic update: model status changed

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).