The protein contains 84 amino acids for an estimated molecular weight of 9461 Da.
Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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The reference OMIM entry for this protein is 603702
The mammalian ribosome is composed of 4 RNA species (see 180450) and approximately 80 different proteins. Using differential hybridization to screen a cDNA library derived from a human mammary carcinoma cell line that was stimulated with TGFB1 (190180) in the presence of cyclohexamide, Fernandez-Pol et al. (1993) isolated a cDNA whose corresponding mRNA was induced by TGFB1. The deduced protein, which the authors named metallopanstimulin-1 (MPS1), has 84 amino acids and an unmodified molecular mass of 9,460 Da. The MPS1 protein contains a predicted zinc finger domain of the C4 type. Immunofluorescence demonstrated that MPS1 is located predominantly in the nucleus. Northern blot analysis detected an approximately 0.4-kb MPS1 transcript which was induced by a variety of growth factors. MPS1 mRNA levels were increased in cultured malignant cells and in cancerous tissue specimens compared to cultured normal cells and normal tissue specimens, respectively. Fernandez-Pol et al. (1994) showed that recombinant MPS1 expressed in the Sf9 insect cell line was phosphorylated and can bind to DNA. Tsui et al. (1996) cloned a human heart cDNA encoding ribosomal protein S27 (RPS27). The deduced human RPS27 protein is 96% identical to the rat Rps27 protein. The RPS27 and MPS1 cDNAs differ by 1 bp; whereas MPS1 contains the putative polyadenylation signal AACAAA, RPS27 contains AATAAA. By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi et al. (1998) mapped the RPS27 gene to chromosome 1. ... More on the omim web site
June 29, 2020: Protein entry updated
Automatic update: OMIM entry 603702 was added.
Dec. 9, 2018: Protein entry updated
Automatic update: model status changed
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).