60S ribosomal protein L39 (RPL39)
The protein contains 51 amino acids for an estimated molecular weight of 6407 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Biological Process
Antibacterial humoral response
Antimicrobial humoral immune response mediated by antimicrobial peptide
Cytoplasmic translation
Defense response to Gram-positive bacterium
Innate immune response in mucosa
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
RRNA processing
SRP-dependent cotranslational protein targeting to membrane
Translation
Translational initiation
Viral transcription
The reference OMIM entry for this protein is 300899
Ribosomal protein l39; rpl39
CLONING
Ribosomes, the site of protein synthesis in the cell, are composed of 4 ribosomal RNA species (see 180450) and approximately 80 ribosomal proteins. Otsuka et al. (1996) cloned the RPL39 gene, the human gene encoding the L39 ribosomal protein, by random cDNA sequencing of a colon carcinoma cDNA library. The gene encodes a 51-amino acid polypeptide. Northern blot analysis revealed ubiquitous expression of the RPL39 transcript. Although the level of RPL39 mRNA varied in several cell lines, including carcinoma cell lines, its level was not cell cycle dependent in fibroblasts. Tsui et al. (1996) isolated a human heart cDNA encoding RPL39. The deduced RPL39 protein has 20 basic residues but no acidic ones; its calculated isoelectric point is 13.05. The predicted human and rat RPL39 proteins are identical.MAPPING
By somatic cell hybrid and radiation hybrid analyses, Uechi et al. (2001) mapped the RPL39 gene to chromosome Xq22. Gross (2013) mapped the RPL39 gene to chromosome Xq24 based on an alignment of the RPL39 sequence (GenBank GENBANK AB061835) with the genomic sequence (GRCh37). ... More on the omim web site
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).
Oct. 19, 2018: Protein entry updated
Automatic update: OMIM entry 300899 was added.