Inositol 1,4,5-triphosphate receptor associated 2 (LRMP)
The protein contains 555 amino acids for an estimated molecular weight of 62122 Da.
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. (updated: June 17, 2020)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is predicted to be membranous by TOPCONS.
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| Variant | Description |
|---|---|
| dbSNP:rs6487451 | |
| dbSNP:rs7969931 | |
| dbSNP:rs1063159 | |
| dbSNP:rs1908946 |
No binding partner found
Biological Process
Neutrophil degranulation
Nucleus organization
Single fertilization
Vesicle fusion
Vesicle targeting
The reference OMIM entry for this protein is 602003
Lymphoid-restricted membrane protein; lrmp
Lymphoid protein of endoplasmic reticulum
Jaw1
CLONING
Behrens et al. (1994) performed a differential screen of a human B-lymphoma cDNA library to identify genes expressed preferentially in B-cell lines. The authors cloned and characterized a gene, which they called JAW1, that is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. JAW1 encodes a 539-amino acid polypeptide with a predicted molecular mass of 59.6 kD. The authors localized JAW1 to the cytoplasmic face of the endoplasmic reticulum (ER) by indirect immunofluorescence and confocal microscopy. The protein has a coiled-coil domain and a C-terminal membrane anchor with a conserved luminal tail region.GENE FUNCTION
Behrens et al. (1996) showed that the 71 C-terminal amino acids of the JAW1 protein, which contain a hydrophobic membrane-spanning region, are both necessary and sufficient for targeting a heterologous protein to the ER.MAPPING
Gross (2014) mapped the LRMP gene to chromosome 12p12.1 based on an alignment of the LRMP sequence (GenBank GENBANK BC126417) with the genomic sequence (GRCh37). ... More on the omim web site
June 29, 2020: Protein entry updated
Automatic update: Entry updated from uniprot information.
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 602003 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).