Late cornified envelope protein 3B (LCE3B)
The protein contains 95 amino acids for an estimated molecular weight of 9812 Da.
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035). (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
(right-click above to access to more options from the contextual menu)
No binding partner found
The reference OMIM entry for this protein is 612614
Late cornified envelope protein 3b; lce3b
Late envelope protein 14; lep14
For background information on the LCE gene cluster, see 612603.
CLONING
By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE3B, which they called LEP14. RT-PCR detected strong LEP14 expression in human esophagus, but not in skin or heart. Using real-time PCR, Jackson et al. (2005) detected little to no LCE3B expression in human skin or internal epithelia.GENE STRUCTURE
Jackson et al. (2005) determined that the LCE3B gene contains 2 exons. Exon 1 is noncoding.MAPPING
By genomic sequence analysis, Marshall et al. (2001) mapped the LCE3B gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) stated that the mouse Lce3b gene maps to a syntenic LCE gene cluster on chromosome 3F1.MOLECULAR GENETICS
For a discussion of a possible association between variants in the LCE3B gene and psoriasis, see PSORS4 (603935). ... More on the omim web site
Dec. 10, 2018: Protein entry updated
Automatic update: model status changed
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 612614 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).