LHFPL tetraspan subfamily member 2 protein (LHFPL2)
The protein contains 228 amino acids for an estimated molecular weight of 24486 Da.
Plays a role in female and male fertility. Involved in distal reproductive tract development. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is predicted to be membranous by TOPCONS.
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| Variant | Description |
|---|---|
| dbSNP:rs2303654 |
No binding partner found
Biological Process
Development of primary female sexual characteristics
Development of primary male sexual characteristics
Platelet degranulation
Positive regulation of fertilization
Single fertilization
Cellular Component
Integral component of membrane
Membrane
Plasma membrane
Platelet alpha granule membrane
Molecular Function
The reference OMIM entry for this protein is 609718
Lhfp-like protein 2; lhfpl2
Kiaa0206
CLONING
By sequencing clones obtained from a size-fractionated immature myeloid cell line cDNA library, Nagase et al. (1996) cloned LHFPL2, which they designated KIAA0206. The deduced protein contains putative transmembrane domains. Northern blot analysis detected LHFPL2 expression in all tissues and cell lines examined except brain and peripheral blood leukocytes. By searching for sequences similar to LHFP (606710), Petit et al. (1999) identified LHFPL2. The deduced 193-amino acid protein shares 27% identity with LHFP.MAPPING
By radiation hybrid and human-rodent hybrid analyses, Nagase et al. (1996) determined that the LHFPL2 gene maps to either chromosome 5 or 11. The International Radiation Hybrid Analysis Consortium mapped the LHFPL2 gene to chromosome 5 (TMAP SHGC-32444). ... More on the omim web site
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 609718 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).