Reticulophagy regulator 3 (RETREG3)
The protein contains 466 amino acids for an estimated molecular weight of 51396 Da.
Mediates NRF1-enhanced neurite outgrowth. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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No binding partner found
Molecular Function
The reference OMIM entry for this protein is 616498
Family with sequence similarity 134, member c; fam134c
DESCRIPTION
FAM134C is regulated by NRF1 (600879) and is involved in neurite outgrowth (Wang et al., 2013).CLONING
Wang et al. (2013) stated that FAM134C is highly expressed in the nervous system. In primary rat hippocampal neurons, Fam134c was predominantly expressed in the axon hillock.GENE FUNCTION
Wang et al. (2013) found that NRF1 increased FAM134C promoter activity in human neuroblastoma cells and primary rat cortical neurons. They identified an NRF1 response element 170 to 159 bp upstream of the FAM134C transcription start site, and the site was 100% conserved in mouse. Treatment of human neuroblastoma cells with short hairpin RNA to FAM134C decreased neurite outgrowth, whereas overexpression of FAM134C increased outgrowth. Wang et al. (2013) concluded that FAM134C is downstream of NRF1 and increases neurite outgrowth.MAPPING
Gross (2015) mapped the FAM134C gene to chromosome 17q21.2 based on an alignment of the FAM134C sequence (GenBank GENBANK BC049370) with the genomic sequence (GRCh38). ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 616498 was added.
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).