Keratin-associated protein 11-1 (KRTAP11-1)
The protein contains 163 amino acids for an estimated molecular weight of 17085 Da.
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs9636845 |
No binding partner found
Molecular Function
The reference OMIM entry for this protein is 600064
Keratin-associated protein 11-1; krtap11-1
Hair follicle-specific gene 1; hacl1
CLONING
From a cDNA library of mouse skin, Huh et al. (1994) isolated a hair-follicle-specific gene which they designated Hacl1. The gene was expressed specifically in skin, and its mRNA level was correlated with the active state of hair follicles in developmental and regenerative processes of hair. Its mRNA was approximately 1 kb. The deduced amino acid sequence showed 6 direct repeats of a decapeptide on the C-terminal side. In situ hybridization showed that the gene is expressed specifically in the keratogenous zone of the cortical cells of the hair shaft.MAPPING
By genomic sequence analysis, Pruett et al. (2004) mapped the mouse Krtap11-1 gene to distal chromosome 16 and the human KRTAP11-1 gene to chromosome 21q22.11, a region of conserved linkage. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 600064 was added.
Dec. 10, 2018: Protein entry updated
Automatic update: model status changed
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).