Tektin-1 (TEKT1)

The protein contains 418 amino acids for an estimated molecular weight of 48283 Da.

 

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. (updated: Sept. 12, 2018)

Protein identification was indicated in the following studies:

  1. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

Interpro domains
Total structural coverage: 0%
Model score: 45

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VariantDescription
dbSNP:rs34431552
dbSNP:rs3744395
dbSNP:rs2271233

No binding partner found

The reference OMIM entry for this protein is 609002

Tektin 1; tekt1

CLONING

Xu et al. (2001) cloned TEKT1 from a fetal brain cDNA library. The deduced 418-amino acid protein has a calculated molecular mass of 48.3 kD. Xu et al. (2001) determined that TEKT1 contains about 76.3% alpha helix, which they predicted forms extended rod homodimers with 4 major coiled-coil segments. TEKT1 has 4 evolutionarily conserved cysteines and a tektin-specific peptide sequence. Northern blot analysis of several human tissues detected TEKT1 only in testis. In situ hybridization of mouse testis found Tekt1 weakly expressed in pachytene spermatocytes at postnatal day 12, with stronger Tekt1 expression in spermatocytes and round spermatids at later developmental stages.

GENE STRUCTURE

Xu et al. (2001) determined that the TEKT1 gene contains 8 exons.

MAPPING

By genomic sequence analysis, Xu et al. (2001) mapped the TEKT1 gene to chromosome 17. ... More on the omim web site

Subscribe to this protein entry history

Feb. 23, 2019: Protein entry updated
Automatic update: model status changed

Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 609002 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).