Phosphotriesterase-related protein (PTER)
The protein contains 349 amino acids for an estimated molecular weight of 39018 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs36023740 |
The reference OMIM entry for this protein is 604446
Phosphotriesterase-related protein; pter
CLONING
Microbial phosphotriesterases are a group of zinc metalloenzymes that catalyze the hydrolysis of a range of phosphotriester compounds. Davies et al. (1997) isolated rat cDNAs encoding a phosphotriesterase homolog that they named rpr1. Using a rat rpr1 cDNA as a hybridization probe, Alimova-Kost et al. (1998) isolated human genomic sequences of PTER, a homolog of phosphotriesterases. Hou et al. (1996) cloned mouse Pter, which they called mpr56-1. The deduced 349-amino acid protein has a calculated molecular mass of 39.2 kD. Northern blot analysis detected highest Pter expression in kidney and lower expression in liver. Pter was not detected in fetal kidney, but it was expressed during the postnatal period and showed highest levels in adult kidney. In situ hybridization revealed highest Pter mRNA expression in proximal tubules.GENE FUNCTION
By differential cDNA library screening, Hou et al. (1996) found that Pter was significantly underexpressed in cystic kidneys of the cpk mouse, a model of human autosomal recessive polycystic kidney disease (ARPKD; 263200). Pter expression was significantly decreased upon acute renal injury induced by a single intraperitoneal injection of folic acid, and normal Pter levels returned upon recovery of kidney function.MAPPING
By FISH, Alimova-Kost et al. (1998) mapped the human PTER gene to chromosome 10p12. ... More on the omim web site
Feb. 23, 2019: Protein entry updated
Automatic update: comparative model was added.
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 604446 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).