Keratin, type II cuticular Hb2 (KRT82)

The protein contains 513 amino acids for an estimated molecular weight of 56653 Da.

 

No function (updated: Sept. 12, 2018)

Protein identification was indicated in the following studies:

  1. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

Interpro domains
Total structural coverage: 30%
Model score: 41

(right-click above to access to more options from the contextual menu)

VariantDescription
dbSNP:rs1791634
dbSNP:rs1732263
dbSNP:rs2658658

Biological Process

Cornification GO Logo
Keratinization GO Logo

Cellular Component

Cytosol GO Logo
Keratin filament GO Logo

The reference OMIM entry for this protein is 601078

Keratin 82, type ii; krt82
K82
Kb22
Keratin, hair, basic, 2; krthb2
Keratin, hard, type ii, 2; hb2

See KRTHA1 (601077) for general information on hair keratins. Bowden et al. (1994) isolated a human genomic clone that encodes the alpha-helical 2B domain and the C-terminal region of HB2. ... More on the omim web site

Subscribe to this protein entry history

Feb. 23, 2019: Protein entry updated
Automatic update: model status changed

Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 601078 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).