Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10)

The protein contains 68 amino acids for an estimated molecular weight of 7205 Da.

 

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3. (updated: Sept. 12, 2018)

Protein identification was indicated in the following studies:

  1. Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
  2. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt.


Interpro domains
Total structural coverage: 90%
Model score: 0
No model available.

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The reference OMIM entry for this protein is 604389

Guanine nucleotide-binding protein, gamma-10; gng10

G protein beta and gamma subunits directly regulate the activities of various enzymes and ion channels. For structural information about these proteins, see 600874. The beta and gamma subunits belong to large multigene families. The beta subunits are highly conserved at the amino acid level, whereas the gamma subunits are more divergent. In the course of identifying and characterizing ESTs from the human genome, Ray et al. (1995) isolated cDNA clones from a variety of tissue- or cell-specific cDNA libraries for 8 different human G protein gamma subunits, 3 of which represented novel subunits (GNG10; GNG4, 604388; and GNG11, 604390). GNG10 encodes a deduced 68-amino acid protein, the sequence of which is only 35 to 53% homologous to the sequence of other known gamma subunits. By Northern blot analysis, GNG10 hybridized to a single 1.4-kb species in all tissues tested. GNG10 was found to associate with the G protein beta-1 (139380) and beta-2 (139390) subunits. ... More on the omim web site

Subscribe to this protein entry history

Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 604389 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).