Sorting nexin-12 (SNX12)
The protein contains 172 amino acids for an estimated molecular weight of 19730 Da.
May be involved in several stages of intracellular trafficking. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
- Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Biological Process
Endocytic recycling
Late endosome to Golgi transport
Negative regulation of early endosome to late endosome transport
Negative regulation of gene expression
Negative regulation of protein catabolic process
Negative regulation of protein processing
Negative regulation of protein transport
Protein transport
Regulation of endocytosis
Regulation of intracellular protein transport
Molecular Function
Enzyme binding
Phosphatidylinositol binding
Phosphatidylinositol-3-phosphate binding
The reference OMIM entry for this protein is 300883
Sorting nexin 12; snx12
DESCRIPTION
SNX12 belongs to a large family of proteins characterized by the presence of an SNX-type phox (see 608512) homology (PX) domain with conserved arg-arg-tyr-X-asp/glu and pro-pro-X-pro-X-lys motifs. SNX family members are predicted to be involved in the sorting of endosomes (Teasdale et al., 2001).CLONING
By searching databases for sequences similar to yeast Snx1 (601272), Teasdale et al. (2001) identified human SNX12. The deduced protein has a central 146-amino acid SNX-PH domain, but it lacks C-terminal coiled-coil motifs found in several other SNX family members.MAPPING
Hartz (2012) mapped the SNX12 gene to chromosome Xq13.1 based on an alignment of the SNX12 sequence (GenBank GENBANK AF171229) with the genomic sequence (GRCh37). ... More on the omim web site
Feb. 23, 2019: Protein entry updated
Automatic update: comparative model was added.
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 300883 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).