The protein contains 128 amino acids for an estimated molecular weight of 13811 Da.
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. (updated: April 1, 2015)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt, is predicted to be membranous by TOPCONS.
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Variant | Description |
---|---|
Webb (WB) antigen | |
Duch (DH(a)) antigen | |
Ahonen (AN(a)) antigen | |
dbSNP:rs28370000 |
The reference OMIM entry for this protein is 110750
The reference OMIM entry for this protein is 616089
A number sign (#) is used with this entry because the Gerbich (Ge) blood group system is based on variation in the GYPC gene (110750) on chromosome 2q14.3.
The reference OMIM entry for this protein is 611162
A number sign (#) is used with this entry because variation in several different genes influences susceptibility and resistance to malaria, as well as disease progression and severity. These genes include HBB (141900), ICAM1 (147840), CD36 (173510), CR1 (120620), GYPA (111300), GYPB (111740), GYPC (110750), TNF (191160), NOS2A (163730), TIRAP (606252), FCGR2B (604590), and CISH (602441). In addition, a locus associated with Plasmodium falciparum blood infection level has been mapped to chromosome 5q31-q33 (PFBI; 248310), a locus for susceptibility to mild malaria has been mapped to chromosome 6p21.3 (MALS; 609148), a locus associated with malaria fever episodes has been mapped to chromosome 10p15 (PFFE1; 611384), and a locus for susceptibility to placental malarial infection has been mapped to chromosome 6 (FUT9; 606865). Complete protection from Plasmodium vivax infection is associated with the Duffy blood group-negative phenotype (see 110700). Alpha(+)-thalassemia (141800), the X-linked disorder G6PD deficiency (300908), and Southeast Asian ovalocytosis (109270) are associated with resistance to malaria.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 616089 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 110750 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 611162 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 616089 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 611162 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 616089 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 110750 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 616089 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 110750 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 611162 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 616089 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 110750 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Sept. 23, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Sept. 23, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Sept. 23, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Aug. 20, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Aug. 20, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Aug. 20, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
July 5, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 5, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 5, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Jan. 21, 2019: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Jan. 21, 2019: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Jan. 21, 2019: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Oct. 19, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
July 7, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 7, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 7, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
July 3, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
July 3, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
July 3, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 110750 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 611162 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 616089 was added.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for GYPC
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 110750 was added.
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed