The protein contains 584 amino acids for an estimated molecular weight of 58827 Da.
Plays a role in the establishment of the epidermal barrier on plantar skin.', '(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.', '(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. (updated: May 8, 2019)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Variant | Description |
---|---|
dbSNP:rs4261597 | |
dbSNP:rs77919366 | |
EHK | |
EHK | |
EHK | |
EHK | |
EHK | |
EHK | |
EHK | |
EHK | |
EHK; severe phenotype | |
EHK | |
EHK | |
AEI | |
EHK | |
EHK | |
AEI | |
EHK | |
dbSNP:rs17855579 |
The reference OMIM entry for this protein is 113800
A number sign (#) is used with this entry because of evidence that epidermolytic hyperkeratosis (EHK) can be caused by heterozygous mutation in the keratin-1 gene (KRT1; 139350) and by heterozygous or homozygous mutation in the keratin-10 gene (KRT10; 148080).
May 11, 2019: Protein entry updated
Automatic update: Entry updated from uniprot information.
May 26, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for KRT10
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 113800 was added.
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed