The protein contains 248 amino acids for an estimated molecular weight of 29226 Da.
Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs. (updated: Jan. 31, 2018)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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The reference OMIM entry for this protein is 604166
The mammalian ribosome is composed of 4 RNA species (see 180450) and approximately 80 different proteins (see 180466). Meyuhas and Klein (1990) identified a transcriptionally active mouse Rpl7 gene. The 3.1-kb Rpl7 gene contains 7 exons and encodes an mRNA that is 897 nucleotides long. Seshadri et al. (1993) partially sequenced the human RPL7 gene and found that it shares many features with those of mouse Rpl7, including the position of the first intron and the polypyrimidine translation control element in the 5-prime noncoding region. By screening cDNA libraries derived from activated human T-lymphocyte cell lines with a mouse Rpl7 cDNA, Hemmerich et al. (1993) isolated human RPL7 cDNAs. The predicted 248-amino acid human RPL7 protein has an N-terminal basic leucine zipper (bZIP)-like domain and the RNP consensus submotif RNP2. The authors demonstrated that the N-terminal region of mammalian RPL7 proteins mediates RPL7 homodimerization and stable binding of RPL7 to DNA and RNA in vitro. They found that RPL7 preferentially binds to 28S rRNA and mRNA. Hemmerich et al. (1993) showed that mouse Rpl7 mRNA is induced upon activation of resting B and T lymphocytes. The RPL7 protein has been shown to be an autoantigen in patients with systemic lupus erythematosus (152700) and other systemic autoimmune diseases (Absi et al., 1989; von Mikecz et al., 1994; Neu et al., 1995; von Mikecz et al., 1995). Sapi et al. (1994) identified a processed pseudogene for ribosomal protein L7 (RPL7P) within intron 1 of the FMS gene (164770). This pseudogene was not actively transcribed. By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi et al. (1998) mapped the human RPL7 gene to 8q. ... More on the omim web site
May 12, 2019: Protein entry updated
Automatic update: model status changed
Nov. 16, 2018: Protein entry updated
Automatic update: model status changed
Feb. 5, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
Oct. 26, 2017: Protein entry updated
Automatic update: model status changed
March 15, 2016: Protein entry updated
Automatic update: OMIM entry 604166 was added.
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed