Blood group Rh(CE) polypeptide (RHCE)
The protein contains 417 amino acids for an estimated molecular weight of 45560 Da.
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is predicted to be membranous by TOPCONS.
(right-click above to access to more options from the contextual menu)
No binding partner found
Biological Process
Ammonium transmembrane transport
Organic cation transport
Peptide biosynthetic process
The reference OMIM entry for this protein is 111690
Blood group--rhesus system e polypeptide; rhe
A number sign (#) is used with this entry because Colin et al. (1991) presented evidence indicating that one gene codes both C/c and E/e specificities (see 111700), whereas another gene codes Rh D specificity (111680). ... More on the omim web site
The reference OMIM entry for this protein is 111700
Rhesus blood group, ccee antigens; rhce
Blood group--rhesus system cc/ee polypeptide
Rhc
Rhe rh-null disease, amorph type, included
Rh, elliptocytosis, PGM1, and 6PGD are all on the same chromosome. The first 2 loci appear to lie between the latter 2 (Renwick, 1971). Information from cell hybridization studies placed the Rh-elliptocytosis-PGM(1)-6PGD linkage group on chromosome 1. Jacobs et al. (1970) reported data suggesting a loose linkage between a translocation breakpoint near the end of the long arm of chromosome 1 and Rh. Lamm et al. (1970) published family data consistent with loose linkage of Duffy and PGM1. Renwick (1971) suggested that PGM1 is on the side of Rh, remote from 6PGD and about 30 centimorgans from Rh. Cook et al. (1972) confirmed this interval. Although the Rh and Duffy loci are both on chromosome 1, they are too far apart to demonstrate linkage in family studies (Sanger et al., 1973). Marsh et al. (1974) found Rh-negative erythrocytes in an Rh-positive man suffering from myelofibrosis. Nucleated hemopoietic precursors were circulating in his blood, and these cells had an abnormal chromosome complement from which part of the short arm of chromosome 1 had been deleted. They concluded that the Rh locus probably lies on the distal segment of the short arm at some point between 1p32 and the end of the short arm. The conclusion is consistent with the finding of Douglas et al. (1973) that the PGM1 locus, which is linked to Rh, is on the short arm of chromosome 1. Since the patient of Marsh et al. (1974) did not have deletion of the PGM1 locus in the mutant clone, the Rh locus is probably distal to the PGM1 locus. Corney et al. (1977) observed only 1 recombination in 58 opportunities between the alpha-fucosidase locus (FUCA1; 612280) and the Rh locus. Rh antigen still eludes chemical definition (Tippett, 1978), but it is thought to be a lipoprotein. No completely certain example of recombination within a postulated gene complex has been described. Steinberg (1965) described a Hutterite family in which the father was CDe-cde, mother cde-cde, 4 children cde-cde, 3 children CDe-cde, and 1 child (the 6th born) Cde-cde. Steinberg (1965) thought this was an instance of crossing-over. Mutation and, much less likely, a recessive suppressor of the D antigen were mentioned as other possibilities. Race and Sanger (1975) considered a recessive suppressor likely. (Illegitimacy was excluded by the mores of the sect and by marker studies.) Rosenfield (1981) wrote: 'We still know nothing about Rh. Except for Steinberg's one crossover, there have been no exceptions to the inheritance of Rh antigens in tight haplotype packages. Hopefully, Rh antigen will be isolated for characterisation but there has been nothing published since the report of Plapp et al. (1979).' Steinberg et al. (1984) reexamined the Hutterite family, making use of other markers thought to be on 1p (6PGD, Colton, UMPK1) and concluded that crossover or mutation indeed had occurred. (Colton is probably not on chromosome 1p; UMPK1 was not informative in the critical parent (Lewis, 1989).) They concluded further that if, as seems likely from other evidence, C lies between D and E, their data indicate that the D gene (116800) is distal (telomeric) in the Rh complex. This order is consistent with the rare Rh haplotype D. Race et al. (1950, 1951) considered this haplotype to represent a probable or possible deletion in a human Rh chromosome. Race and Sanger (1975) listed 20 homozygotes for this haplotype. Originating from various populations, they were, in about 80% of the cases, the products of consanguine ... More on the omim web site
July 1, 2021: Protein entry updated
Automatic update: OMIM entry 111700 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Feb. 16, 2021: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 111700 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 111700 was added.
April 25, 2020: Protein entry updated
Automatic update: OMIM entry 111700 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Sept. 22, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Aug. 20, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 4, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
April 2, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Feb. 23, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Jan. 21, 2019: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Dec. 10, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Dec. 9, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Oct. 19, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
Oct. 19, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
May 26, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
May 26, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 111690 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 111700 was added.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for RHCE
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 111690 was added.