Transgelin-2 (TAGLN2)

The protein contains 199 amino acids for an estimated molecular weight of 22391 Da.

 

No function (updated: March 4, 2015)

Protein identification was indicated in the following studies:

  1. Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
  2. Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
  3. Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
  4. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
  5. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete
TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.

Interpro domains
Total structural coverage: 78%
Model score: 21

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VariantDescription
dbSNP:rs17849636

The reference OMIM entry for this protein is 604634

Transgelin 2; tagln2

CLONING

By sequencing cDNAs randomly selected from a cDNA library derived from a human immature myeloid cell line, Nagase et al. (1995) isolated a cDNA encoding TAGLN2, which they called KIAA0120. The deduced 199-amino acid TAGLN2 protein shares 69.7% amino acid sequence identity with rat neuronal protein NP25 (607953) over 195 amino acids. Northern blot analysis detected TAGLN2 expression in all 16 human tissues examined, with high expression in lung, liver, kidney, spleen, thymus, small intestine, colon, prostate, testis, ovary, placenta, and peripheral blood leukocytes, lower expression in skeletal muscle, pancreas, and heart, and lowest expression in brain. Stanier et al. (1998) cloned mouse Tagln2 cDNAs. They found that mouse and human TAGLN2 share 95% amino acid sequence identity.

MAPPING

Using a somatic cell hybrid mapping panel, Nagase et al. (1995) determined that the TAGLN2 gene maps to either chromosome 1 or 8. Stanier et al. (1998) noted that an EST cluster representing the TAGLN2 gene had been mapped to 1q21-q25. By linkage analysis, Stanier et al. (1998) mapped the mouse Tagln2 gene to distal chromosome 1, between the Fcgr2 gene (146790) and marker D1Mit149. Distal mouse chromosome 1 shows homology of synteny with human 1q21-q25. ... More on the omim web site

Subscribe to this protein entry history

Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated

Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated

June 20, 2017: Protein entry updated
Automatic update: comparative model was added.

March 16, 2016: Protein entry updated
Automatic update: OMIM entry 604634 was added.

Jan. 28, 2016: Protein entry updated
Automatic update: model status changed

Jan. 25, 2016: Protein entry updated
Automatic update: model status changed