Knottins can be obtained either:
- • By extraction from natural sources
[Favel et al, 1989;
Saether et al, 1995;
Hernandez et al, 2000;
Cemazar et al, 2006]
- • By chemical synthesis
- • As expressed recombinant proteins
[Camarero et al, 2007;
Krause et al, 2007;
Cui et al, 2007;
Kimura et al, 2006;
Kimura & Camarero, 2005;
Ji et al, 2005;
Schmoldt et al, 2005;
Kratzner et al, 2005;
Escoubas et al, 2003;
Chen et al, 1992]
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