Sequence     &     Structural     Information 
	

		
			

				PTM
			

		
		
			

				PTM
				Methylation
			

		

		
			

				Sequence Information
			


		
		
			

				Uniprot AC
				P62805
			

			

				Organism
				HUMAN (Human)
			

			

				Modified Amino Acid
				K(Lys) 21
			

			

				Annotation dbPTM details
				N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine		
			

		

		
			

				Structure Information
			


		
		
			

				PDB ID Code
				2BQZ
			

			

				Model
				-
			

			

				Chain
				B
			

			

				Position
				20
			

			

				SCOP Class
				None
			

			

				MODRES
				N-METHYL-LYSINE                          
			

		

		
			

				Related PTM
			


		
		
			

				Found in same PDB Chain
				-
			

			

				Found in same Uniprot AC
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PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
Gallery (?)
Slide 1
Slide 2
Example Frame 



Note: As the images production is automatic, the focus on the PTM site could not be the most optimized.
      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.
Alignment
(?) 

	           Numerotation

	(?)       Uniprot Sequence
	(?)                Clustal
	(?)           PDB Sequence
	(?)        PDB Information
	(?)          DSSP Sequence
	(?) Protein Block Sequence
	
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MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
                 *** *****                         *                                                   
-----------------RHRXVLRDN-------------------------Y---------------------------------------------------
                 ___H_____                         _                                                   
                 CCCEECCCC                         C                                                   
                 ZZdddedfZ                         Z

Scripts     (PyMol,     Modeller,     ...)

PyMol 
	Download
Modeller 
	
If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
RHRXVLRDNY 
1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			
				

MODRES 2BQZ MLZ B   20  LYS  N-METHYL-LYSINE                                    
LINK         C   ARG B  19                 N   MLZ B  20     1555   1555  1.34  
LINK         C   MLZ B  20                 N   VAL B  21     1555   1555  1.44  
SITE     4 AC1 16 HOH A2318  HIS B  18  MLZ B  20  HOH E2136                    
HETATM 1324  N   MLZ B  20       3.617  -6.042   0.333  1.00  4.42           N  
ANISOU 1324  N   MLZ B  20      507    619    551     25    -16     55       N  
HETATM 1325  CA  MLZ B  20       3.308  -5.258   1.507  1.00  5.12           C  
ANISOU 1325  CA  MLZ B  20      576    658    711    -57     -4     17       C  
HETATM 1326  CB  MLZ B  20       2.292  -4.156   1.219  1.00  5.99           C  
ANISOU 1326  CB  MLZ B  20      711    741    824     -1    -11     29       C  
HETATM 1327  CG  MLZ B  20       2.729  -3.154   0.173  1.00  7.09           C  
ANISOU 1327  CG  MLZ B  20      864    858    969    -70    -11     45       C  
HETATM 1328  CD  MLZ B  20       1.584  -2.231  -0.283  1.00  9.21           C  
ANISOU 1328  CD  MLZ B  20     1049   1118   1330    -12     47     74       C  
HETATM 1329  CE  MLZ B  20       2.085  -1.650  -1.594  1.00 11.14           C  
ANISOU 1329  CE  MLZ B  20     1276   1357   1599    -85     35    180       C  
HETATM 1330  NZ  MLZ B  20       1.180  -1.000  -2.467  1.00 13.04           N  
ANISOU 1330  NZ  MLZ B  20     1558   1843   1553    -83     15    182       N  
HETATM 1331  CM  MLZ B  20       1.707  -0.310  -3.618  1.00  9.89           C  
ANISOU 1331  CM  MLZ B  20     1168   1453   1136    -48    -14      0       C  
HETATM 1332  C   MLZ B  20       2.734  -6.240   2.490  1.00  5.78           C  
ANISOU 1332  C   MLZ B  20      759    707    727    -26    -17     24       C  
HETATM 1333  O   MLZ B  20       2.064  -7.180   2.113  1.00  5.32           O  
ANISOU 1333  O   MLZ B  20      598    648    776    -40    -55    -22       O