Sequence     &     Structural     Information 
	

		
			

				PTM
			

		
		
			

				PTM
				Methylation
			

		

		
			

				Sequence Information
			


		
		
			

				Uniprot AC
				P62805
			

			

				Organism
				HUMAN (Human)
			

			

				Modified Amino Acid
				K(Lys) 21
			

			

				Annotation dbPTM details
				N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine		
			

		

		
			

				Structure Information
			


		
		
			

				PDB ID Code
				2BQZ
			

			

				Model
				-
			

			

				Chain
				F
			

			

				Position
				20
			

			

				SCOP Class
				None
			

			

				MODRES
				N-METHYL-LYSINE                          
			

		

		
			

				Related PTM
			


		
		
			

				Found in same PDB Chain
				-
			

			

				Found in same Uniprot AC
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PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
Gallery (?)
Slide 1
Slide 2
Example Frame 



Note: As the images production is automatic, the focus on the PTM site could not be the most optimized.
      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.
Alignment
(?) 

	           Numerotation

	(?)       Uniprot Sequence
	(?)                Clustal
	(?)           PDB Sequence
	(?)        PDB Information
	(?)          DSSP Sequence
	(?) Protein Block Sequence
	
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MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
                 *** *****                         *                                                   
-----------------RHRXVLRDN-------------------------Y---------------------------------------------------
                 ___H_____                         _                                                   
                 CCCEECCSC                         C                                                   
                 ZZddddeeZ                         Z

Scripts     (PyMol,     Modeller,     ...)

PyMol 
	Download
Modeller 
	
If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
RHRXVLRDNY 
1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			
				

MODRES 2BQZ MLZ F   20  LYS  N-METHYL-LYSINE                                    
LINK         C   ARG F  19                 N   MLZ F  20     1555   1555  1.31  
LINK         C   MLZ F  20                 N   VAL F  21     1555   1555  1.39  
SITE     5 AC2 20 HOH E2247  HOH E2248  HIS F  18  MLZ F  20                    
HETATM 2713  N   MLZ F  20       7.775  31.394  25.461  1.00  5.97           N  
ANISOU 2713  N   MLZ F  20      728    772    769    -23      8     -6       N  
HETATM 2714  CA  MLZ F  20       8.240  30.027  25.412  1.00  5.67           C  
ANISOU 2714  CA  MLZ F  20      715    754    683    -12     -2    -50       C  
HETATM 2715  CB  MLZ F  20       9.159  29.785  24.229  1.00  6.32           C  
ANISOU 2715  CB  MLZ F  20      763    830    804     31     31    -50       C  
HETATM 2716  CG  MLZ F  20       8.449  30.058  22.908  1.00  7.42           C  
ANISOU 2716  CG  MLZ F  20     1009    863    945    -41   -119    -65       C  
HETATM 2717  CD  MLZ F  20       9.409  30.028  21.714  1.00  9.80           C  
ANISOU 2717  CD  MLZ F  20     1194   1277   1249    -13    -90    -86       C  
HETATM 2718  CE  MLZ F  20       8.664  30.604  20.512  1.00 11.08           C  
ANISOU 2718  CE  MLZ F  20     1391   1579   1240     50    -94    -38       C  
HETATM 2719  NZ  MLZ F  20       9.438  31.092  19.422  1.00 13.83           N  
ANISOU 2719  NZ  MLZ F  20     1554   1825   1874    -98   -134    135       N  
HETATM 2720  CM  MLZ F  20       8.787  31.732  18.306  1.00 12.90           C  
ANISOU 2720  CM  MLZ F  20     1621   1680   1598    -89    -39     43       C  
HETATM 2721  C   MLZ F  20       8.981  29.774  26.682  1.00  5.95           C  
ANISOU 2721  C   MLZ F  20      677    818    763     28     23    -32       C  
HETATM 2722  O   MLZ F  20       9.604  30.663  27.217  1.00  6.19           O  
ANISOU 2722  O   MLZ F  20      746    772    833    -22    -27     12       O