PTM
			
		
		

			

				
PTM
				
Methylation
			
		

		

			

				
Sequence Information
			

		
		

			

				
Uniprot AC
				
P62805
			
			

				
Organism
				
HUMAN (Human)
			
			

				
Modified Amino Acid
				
K(Lys) 21
			
			

				
Annotation dbPTM details
				
N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine
			
		

		

			

				
Structure Information
			

		
		

			

				
PDB ID Code
				
2IG0
			
			

				
Model
				
-
			
			

				
Chain
				
B
			
			

				
Position
				
20
			
			

				
SCOP Class
				
None
			
			

				
MODRES
				
N-DIMETHYL-LYSINE                        
			
		

		

			

				
Related PTM
			

		
		

			

				
Found in same PDB Chain
				
-
			
			

				
Found in same Uniprot AC
Sort by:
PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
				
2BQZ-B_K21	2BQZ-F_K21	

2KWN-B_K17	

2KWO-B_S2	

2LVM-B_K21	

2QQS-C_K21	2QQS-D_K21	

2RJE-P_K21	2RJE-Q_K21	

2RNY-B_K21	

2RS9-A_K6	

3F9X-E_K21	3F9X-F_K21	3F9X-G_K21	3F9X-H_K21	

3F9Y-E_K21	3F9Y-F_K21	

3IJ1-B_K21	

3JPX-B_K21	

3O36-E_K17	

3QBY-H_K21	

3QZS-C_K17	3QZS-D_K17	

3QZT-B_K17	

3QZV-C_K13	

3UVW-B_K6	3UVW-B_K9	

3UVX-B_K13	3UVX-B_K17	

3UVY-B_K17	3UVY-B_K21	

4N3W-C_K21	

4N4F-C_K13	

4QUT-B_K13	

4QUU-B_K6	

4QYD-B_K13
S2_2KWO-B	

K6_2RS9-A	K6_3UVW-B	K6_4QUU-B	

K9_3UVW-B	

K13_3QZV-C	K13_3UVX-B	K13_4N4F-C	K13_4QUT-B	
K13_4QYD-B	

K17_2KWN-B	K17_3O36-E	K17_3QZS-C	K17_3QZS-D	
K17_3QZT-B	K17_3UVX-B	K17_3UVY-B	

K21_2BQZ-B	K21_2BQZ-F	K21_2LVM-B	K21_2QQS-C	
K21_2QQS-D	K21_2RJE-P	K21_2RJE-Q	K21_2RNY-B	
K21_3F9X-E	K21_3F9X-F	K21_3F9X-G	K21_3F9X-H	
K21_3F9Y-E	K21_3F9Y-F	K21_3IJ1-B	K21_3JPX-B	
K21_3QBY-H	K21_3UVY-B	K21_4N3W-C
			
		
	
		
	

Note: As the images production is automatic, the focus on the PTM site could not be the most optimized.
      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.

	Download

	
If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
			

1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			

				

REMARK 470     MLY B  20    O                                                   
REMARK 500   CH2  MLY B    20     O    HOH B   161              2.06            
MODRES 2IG0 MLY B   20  LYS  N-DIMETHYL-LYSINE                                  
LINK         C   ARG B  19                 N   MLY B  20     1555   1555  1.34  
HETATM 1111  N   MLY B  20      -6.972   3.713   7.647  1.00 66.83           N  
HETATM 1112  CA  MLY B  20      -7.945   4.007   8.702  1.00 66.12           C  
HETATM 1113  CB  MLY B  20      -7.563   3.433  10.090  1.00 66.14           C  
HETATM 1114  CG  MLY B  20      -6.190   2.767  10.319  1.00 62.14           C  
HETATM 1115  CD  MLY B  20      -6.348   1.267  10.585  1.00 57.11           C  
HETATM 1116  CE  MLY B  20      -5.852   0.609  11.891  1.00 48.56           C  
HETATM 1117  NZ  MLY B  20      -4.372   0.320  11.992  1.00 38.99           N  
HETATM 1118  CH1 MLY B  20      -4.088  -1.008  12.569  1.00 39.49           C  
HETATM 1119  CH2 MLY B  20      -3.615   0.499  10.740  1.00 42.72           C  
HETATM 1120  C   MLY B  20      -8.164   5.501   8.806  1.00 66.34           C  
TER    1121      MLY B  20