Sequence     &     Structural     Information 
	

		
			

				PTM
			

		
		
			

				PTM
				Methylation
			

		

		
			

				Sequence Information
			


		
		
			

				Uniprot AC
				P62805
			

			

				Organism
				HUMAN (Human)
			

			

				Modified Amino Acid
				K(Lys) 21
			

			

				Annotation dbPTM details
				N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine		
			

		

		
			

				Structure Information
			


		
		
			

				PDB ID Code
				2LVM
			

			

				Model
				1
			

			

				Chain
				B
			

			

				Position
				20
			

			

				SCOP Class
				None
			

			

				MODRES
				N-DIMETHYL-LYSINE                        
			

		

		
			

				Related PTM
			


		
		
			

				Found in same PDB Chain
				-
			

			

				Found in same Uniprot AC
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PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
Gallery (?)
Slide 1
Slide 2
Example Frame 



Note: As the images production is automatic, the focus on the PTM site could not be the most optimized.
      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.
Alignment
(?) 

	           Numerotation

	(?)       Uniprot Sequence
	(?)                Clustal
	(?)           PDB Sequence
	(?)        PDB Information
	(?)          DSSP Sequence
	(?) Protein Block Sequence
	
         1         2         3         4         5         6         7         8         9         10        
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MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
              ****** *******                                                                           
--------------GAKRHRXVLRDNIQ---------------------------------------------------------------------------
              ______H_______                                                                           
              CCCCCSCCCCSSCC                                                                           
              ZZcfbdcddfklZZ

Scripts     (PyMol,     Modeller,     ...)

PyMol 
	Download
Modeller 
	
If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
GAKRHRXVLRDNIQ 
1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			
				



This structure was solved By NMR.
The PDB records below correspond to the MODEL 1.


REMARK 500  4 MLY B  20       18.51     42.57                                   
MODRES 2LVM MLY B   20  LYS  N-DIMETHYL-LYSINE                                  
LINK         C   ARG B  19                 N   MLY B  20     1555   1555  1.33  
LINK         C   MLY B  20                 N   VAL B  21     1555   1555  1.33  
HETATM 2055  N   MLY B  20     -22.758 -19.378  -9.484  1.00  0.00           N  
HETATM 2056  CA  MLY B  20     -23.214 -18.030  -9.173  1.00  0.00           C  
HETATM 2057  CB  MLY B  20     -23.491 -17.924  -7.660  1.00  0.00           C  
HETATM 2058  CG  MLY B  20     -23.626 -16.505  -7.077  1.00  0.00           C  
HETATM 2059  CD  MLY B  20     -22.273 -15.903  -6.649  1.00  0.00           C  
HETATM 2060  CE  MLY B  20     -21.990 -14.579  -7.354  1.00  0.00           C  
HETATM 2061  NZ  MLY B  20     -20.609 -14.072  -7.155  1.00  0.00           N  
HETATM 2062  CH1 MLY B  20     -20.248 -13.658  -5.777  1.00  0.00           C  
HETATM 2063  CH2 MLY B  20     -19.511 -14.779  -7.867  1.00  0.00           C  
HETATM 2064  C   MLY B  20     -22.182 -17.052  -9.708  1.00  0.00           C  
HETATM 2065  O   MLY B  20     -21.008 -17.089  -9.355  1.00  0.00           O  
HETATM 2066  H   MLY B  20     -22.380 -19.937  -8.731  1.00  0.00           H  
HETATM 2067  HA  MLY B  20     -24.143 -17.828  -9.714  1.00  0.00           H  
HETATM 2068  HB2 MLY B  20     -22.716 -18.452  -7.101  1.00  0.00           H  
HETATM 2069  HB3 MLY B  20     -24.425 -18.451  -7.471  1.00  0.00           H  
HETATM 2070  HG2 MLY B  20     -24.247 -16.572  -6.182  1.00  0.00           H  
HETATM 2071  HG3 MLY B  20     -24.161 -15.861  -7.778  1.00  0.00           H  
HETATM 2072  HD2 MLY B  20     -21.462 -16.606  -6.829  1.00  0.00           H  
HETATM 2073  HD3 MLY B  20     -22.312 -15.699  -5.583  1.00  0.00           H  
HETATM 2074  HE2 MLY B  20     -22.696 -13.849  -6.980  1.00  0.00           H  
HETATM 2075  HE3 MLY B  20     -22.197 -14.667  -8.413  1.00  0.00           H  
HETATM 2076 HH11 MLY B  20     -19.509 -14.333  -5.350  1.00  0.00           H  
HETATM 2077 HH12 MLY B  20     -19.821 -12.660  -5.813  1.00  0.00           H  
HETATM 2078 HH13 MLY B  20     -21.117 -13.629  -5.120  1.00  0.00           H  
HETATM 2079 HH21 MLY B  20     -18.581 -14.223  -7.745  1.00  0.00           H  
HETATM 2080 HH22 MLY B  20     -19.373 -15.787  -7.475  1.00  0.00           H  
HETATM 2081 HH23 MLY B  20     -19.711 -14.844  -8.939  1.00  0.00           H  
HETATM 2082  HZ  MLY B  20     -20.681 -13.171  -7.680  1.00  0.00           H