PTM
			
		
		

			

				
PTM
				
Methylation
			
		

		

			

				
Sequence Information
			

		
		

			

				
Uniprot AC
				
P62805
			
			

				
Organism
				
HUMAN (Human)
			
			

				
Modified Amino Acid
				
K(Lys) 21
			
			

				
Annotation dbPTM details
				
N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine
			
		

		

			

				
Structure Information
			

		
		

			

				
PDB ID Code
				
2RJE
			
			

				
Model
				
-
			
			

				
Chain
				
P
			
			

				
Position
				
20
			
			

				
SCOP Class
				
None
			
			

				
MODRES
				
N-DIMETHYL-LYSINE                        
			
		

		

			

				
Related PTM
			

		
		

			

				
Found in same PDB Chain
				
-
			
			

				
Found in same Uniprot AC
Sort by:
PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
				
2BQZ-B_K21	2BQZ-F_K21	

2IG0-B_K21	

2KWN-B_K17	

2KWO-B_S2	

2LVM-B_K21	

2QQS-C_K21	2QQS-D_K21	

2RJE-Q_K21	

2RNY-B_K21	

2RS9-A_K6	

3F9X-E_K21	3F9X-F_K21	3F9X-G_K21	3F9X-H_K21	

3F9Y-E_K21	3F9Y-F_K21	

3IJ1-B_K21	

3JPX-B_K21	

3O36-E_K17	

3QBY-H_K21	

3QZS-C_K17	3QZS-D_K17	

3QZT-B_K17	

3QZV-C_K13	

3UVW-B_K6	3UVW-B_K9	

3UVX-B_K13	3UVX-B_K17	

3UVY-B_K17	3UVY-B_K21	

4N3W-C_K21	

4N4F-C_K13	

4QUT-B_K13	

4QUU-B_K6	

4QYD-B_K13
S2_2KWO-B	

K6_2RS9-A	K6_3UVW-B	K6_4QUU-B	

K9_3UVW-B	

K13_3QZV-C	K13_3UVX-B	K13_4N4F-C	K13_4QUT-B	
K13_4QYD-B	

K17_2KWN-B	K17_3O36-E	K17_3QZS-C	K17_3QZS-D	
K17_3QZT-B	K17_3UVX-B	K17_3UVY-B	

K21_2BQZ-B	K21_2BQZ-F	K21_2IG0-B	K21_2LVM-B	
K21_2QQS-C	K21_2QQS-D	K21_2RJE-Q	K21_2RNY-B	
K21_3F9X-E	K21_3F9X-F	K21_3F9X-G	K21_3F9X-H	
K21_3F9Y-E	K21_3F9Y-F	K21_3IJ1-B	K21_3JPX-B	
K21_3QBY-H	K21_3UVY-B	K21_4N3W-C
			
		
	
		
	

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      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.

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If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
			

1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			

				

MODRES 2RJE MLY P   20  LYS  N-DIMETHYL-LYSINE                                  
LINK         C   ARG P  19                 N   MLY P  20     1555   1555  1.33  
LINK         C   MLY P  20                 N   VAL P  21     1555   1555  1.33  
HETATM 7642  N   MLY P  20     139.016  61.790  23.736  1.00 28.53           N  
HETATM 7643  CA  MLY P  20     138.982  61.405  25.130  1.00 28.85           C  
HETATM 7644  CB  MLY P  20     138.341  62.523  25.938  1.00 28.46           C  
HETATM 7645  CG  MLY P  20     139.287  63.710  26.138  1.00 26.38           C  
HETATM 7646  CD  MLY P  20     138.530  64.929  26.656  1.00 23.37           C  
HETATM 7647  CE  MLY P  20     139.382  66.139  27.086  1.00 19.70           C  
HETATM 7648  NZ  MLY P  20     138.532  67.365  26.997  1.00 20.93           N  
HETATM 7649  CH1 MLY P  20     137.525  67.362  28.077  1.00 23.72           C  
HETATM 7650  CH2 MLY P  20     139.378  68.574  27.144  1.00 23.15           C  
HETATM 7651  C   MLY P  20     138.117  60.163  25.186  1.00 29.27           C  
HETATM 7652  O   MLY P  20     137.026  60.150  24.597  1.00 29.73           O