PTM
			
		
		

			

				
PTM
				
Acetylation
			
		

		

			

				
Sequence Information
			

		
		

			

				
Uniprot AC
				
P62805
			
			

				
Organism
				
HUMAN (Human)
			
			

				
Modified Amino Acid
				
K(Lys) 21
			
			

				
Annotation dbPTM details
				
N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine
			
		

		

			

				
Structure Information
			

		
		

			

				
PDB ID Code
				
2RNY
			
			

				
Model
				
1
			
			

				
Chain
				
B
			
			

				
Position
				
20
			
			

				
SCOP Class
				
None
			
			

				
MODRES
				
N(6)-ACETYLLYSINE                        
			
		

		

			

				
Related PTM
			

		
		

			

				
Found in same PDB Chain
				
-
			
			

				
Found in same Uniprot AC
Sort by:
PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
				
2BQZ-B_K21	2BQZ-F_K21	

2IG0-B_K21	

2KWN-B_K17	

2KWO-B_S2	

2LVM-B_K21	

2QQS-C_K21	2QQS-D_K21	

2RJE-P_K21	2RJE-Q_K21	

2RS9-A_K6	

3F9X-E_K21	3F9X-F_K21	3F9X-G_K21	3F9X-H_K21	

3F9Y-E_K21	3F9Y-F_K21	

3IJ1-B_K21	

3JPX-B_K21	

3O36-E_K17	

3QBY-H_K21	

3QZS-C_K17	3QZS-D_K17	

3QZT-B_K17	

3QZV-C_K13	

3UVW-B_K6	3UVW-B_K9	

3UVX-B_K13	3UVX-B_K17	

3UVY-B_K17	3UVY-B_K21	

4N3W-C_K21	

4N4F-C_K13	

4QUT-B_K13	

4QUU-B_K6	

4QYD-B_K13
S2_2KWO-B	

K6_2RS9-A	K6_3UVW-B	K6_4QUU-B	

K9_3UVW-B	

K13_3QZV-C	K13_3UVX-B	K13_4N4F-C	K13_4QUT-B	
K13_4QYD-B	

K17_2KWN-B	K17_3O36-E	K17_3QZS-C	K17_3QZS-D	
K17_3QZT-B	K17_3UVX-B	K17_3UVY-B	

K21_2BQZ-B	K21_2BQZ-F	K21_2IG0-B	K21_2LVM-B	
K21_2QQS-C	K21_2QQS-D	K21_2RJE-P	K21_2RJE-Q	
K21_3F9X-E	K21_3F9X-F	K21_3F9X-G	K21_3F9X-H	
K21_3F9Y-E	K21_3F9Y-F	K21_3IJ1-B	K21_3JPX-B	
K21_3QBY-H	K21_3UVY-B	K21_4N3W-C
			
		
	
		
	

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      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.

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If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
			

1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			

				


This structure was solved By NMR.
The PDB records below correspond to the MODEL 1.


REMARK 500  1 ALY B  20      -93.74    -53.24                                   
MODRES 2RNY ALY B   20  LYS  N(6)-ACETYLLYSINE                                  
LINK         C   ARG B  19                 N   ALY B  20     1555   1555  1.33  
LINK         C   ALY B  20                 N   VAL B  21     1555   1555  1.32  
HETATM 2138  OH  ALY B  20     -11.389   3.359  -3.413  1.00  0.00           O  
HETATM 2139  CH  ALY B  20     -10.658   2.469  -3.847  1.00  0.00           C  
HETATM 2140  CH3 ALY B  20      -9.228   2.353  -3.307  1.00  0.00           C  
HETATM 2141  NZ  ALY B  20     -11.057   1.631  -4.798  1.00  0.00           N  
HETATM 2142  CE  ALY B  20     -10.279   1.344  -5.999  1.00  0.00           C  
HETATM 2143  CD  ALY B  20     -11.022   0.439  -6.962  1.00  0.00           C  
HETATM 2144  CG  ALY B  20     -11.495  -0.829  -6.276  1.00  0.00           C  
HETATM 2145  CB  ALY B  20     -12.956  -0.752  -5.894  1.00  0.00           C  
HETATM 2146  CA  ALY B  20     -13.933  -0.686  -7.085  1.00  0.00           C  
HETATM 2147  N   ALY B  20     -15.008   0.245  -6.751  1.00  0.00           N  
HETATM 2148  C   ALY B  20     -14.529  -2.056  -7.398  1.00  0.00           C  
HETATM 2149  O   ALY B  20     -14.915  -2.338  -8.533  1.00  0.00           O  
HETATM 2150 HH31 ALY B  20      -9.132   2.949  -2.411  1.00  0.00           H  
HETATM 2151 HH32 ALY B  20      -9.014   1.320  -3.078  1.00  0.00           H  
HETATM 2152 HH33 ALY B  20      -8.532   2.708  -4.052  1.00  0.00           H  
HETATM 2153  HZ  ALY B  20     -11.925   1.187  -4.702  1.00  0.00           H  
HETATM 2154  HE3 ALY B  20     -10.059   2.271  -6.500  1.00  0.00           H  
HETATM 2155  HE2 ALY B  20      -9.358   0.865  -5.713  1.00  0.00           H  
HETATM 2156  HD3 ALY B  20     -11.879   0.967  -7.351  1.00  0.00           H  
HETATM 2157  HD2 ALY B  20     -10.361   0.172  -7.772  1.00  0.00           H  
HETATM 2158  HG3 ALY B  20     -11.360  -1.657  -6.944  1.00  0.00           H  
HETATM 2159  HG2 ALY B  20     -10.909  -0.978  -5.372  1.00  0.00           H  
HETATM 2160  HB3 ALY B  20     -13.188  -1.618  -5.292  1.00  0.00           H  
HETATM 2161  HB2 ALY B  20     -13.094   0.132  -5.291  1.00  0.00           H  
HETATM 2162  HA  ALY B  20     -13.416  -0.313  -7.957  1.00  0.00           H  
HETATM 2163  H   ALY B  20     -14.953   0.736  -5.907  1.00  0.00           H