Sequence     &     Structural     Information 
	

		
			

				PTM
			

		
		
			

				PTM
				Acetylation
			

		

		
			

				Sequence Information
			


		
		
			

				Uniprot AC
				P62805
			

			

				Organism
				HUMAN (Human)
			

			

				Modified Amino Acid
				K(Lys) 6
			

			

				Annotation dbPTM details
				N6-acetyllysine.
N6-acetyllysine		
			

		

		
			

				Structure Information
			


		
		
			

				PDB ID Code
				2RS9
			

			

				Model
				1
			

			

				Chain
				A
			

			

				Position
				5
			

			

				SCOP Class
				None
			

			

				MODRES
				N(6)-ACETYLLYSINE                        
			

		

		
			

				Related PTM
			


		
		
			

				Found in same PDB Chain
				-
			

			

				Found in same Uniprot AC
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PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
Gallery (?)
Slide 1
Slide 2
Example Frame 



Note: As the images production is automatic, the focus on the PTM site could not be the most optimized.
      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.
Alignment
(?) 

	           Numerotation

	(?)       Uniprot Sequence
	(?)                Clustal
	(?)           PDB Sequence
	(?)        PDB Information
	(?)          DSSP Sequence
	(?) Protein Block Sequence
	
         1         2         3         4         5         6         7         8         9         10        
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MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
 **** *****                                                                                            
-SGRGXGGKGL--------------------------------------------------------------------------------------------
 ____H_____                                                                                            
 CCCSSSSCCC                                                                                            
 ZZgjiacdZZ

Scripts     (PyMol,     Modeller,     ...)

PyMol 
	Download
Modeller 
	
If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
SGRGXGGKGL 
1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			
				



This structure was solved By NMR.
The PDB records below correspond to the MODEL 1.


MODRES 2RS9 ALY A    5  LYS  N(6)-ACETYLLYSINE                                  
LINK         C   GLY A   4                 N   ALY A   5     1555   1555  1.34  
LINK         C   ALY A   5                 N   GLY A   6     1555   1555  1.34  
HETATM   52  OH  ALY A   5      12.157  -1.503   8.288  1.00  0.00           O  
HETATM   53  CH  ALY A   5      11.398  -0.587   7.990  1.00  0.00           C  
HETATM   54  CH3 ALY A   5      10.109  -0.913   7.273  1.00  0.00           C  
HETATM   55  NZ  ALY A   5      11.597   0.713   8.240  1.00  0.00           N  
HETATM   56  CE  ALY A   5      12.694   1.436   8.917  1.00  0.00           C  
HETATM   57  CD  ALY A   5      13.751   0.572   9.633  1.00  0.00           C  
HETATM   58  CG  ALY A   5      14.819   0.028   8.667  1.00  0.00           C  
HETATM   59  CB  ALY A   5      15.557  -1.190   9.240  1.00  0.00           C  
HETATM   60  CA  ALY A   5      16.394  -1.896   8.148  1.00  0.00           C  
HETATM   61  N   ALY A   5      16.270  -3.359   8.327  1.00  0.00           N  
HETATM   62  C   ALY A   5      17.862  -1.424   8.017  1.00  0.00           C  
HETATM   63  O   ALY A   5      18.236  -0.336   8.462  1.00  0.00           O  
HETATM   64 HH31 ALY A   5      10.070  -0.378   6.327  1.00  0.00           H  
HETATM   65 HH32 ALY A   5      10.065  -1.987   7.085  1.00  0.00           H  
HETATM   66 HH33 ALY A   5       9.263  -0.625   7.896  1.00  0.00           H  
HETATM   67  HZ  ALY A   5      10.845   1.305   7.917  1.00  0.00           H  
HETATM   68  HE3 ALY A   5      13.195   2.087   8.196  1.00  0.00           H  
HETATM   69  HE2 ALY A   5      12.240   2.084   9.669  1.00  0.00           H  
HETATM   70  HD3 ALY A   5      14.259   1.191  10.374  1.00  0.00           H  
HETATM   71  HD2 ALY A   5      13.256  -0.234  10.174  1.00  0.00           H  
HETATM   72  HG3 ALY A   5      14.340  -0.253   7.729  1.00  0.00           H  
HETATM   73  HG2 ALY A   5      15.544   0.810   8.452  1.00  0.00           H  
HETATM   74  HB3 ALY A   5      16.185  -0.895  10.082  1.00  0.00           H  
HETATM   75  HB2 ALY A   5      14.803  -1.886   9.611  1.00  0.00           H  
HETATM   76  HA  ALY A   5      15.948  -1.628   7.186  1.00  0.00           H  
HETATM   77  H   ALY A   5      15.604  -3.841   7.739  1.00  0.00           H