Sequence     &     Structural     Information 
	

		
			

				PTM
			

		
		
			

				PTM
				Acetylation
			

		

		
			

				Sequence Information
			


		
		
			

				Uniprot AC
				P62805
			

			

				Organism
				HUMAN (Human)
			

			

				Modified Amino Acid
				K(Lys) 21
			

			

				Annotation dbPTM details
				N6,N6,N6-trimethyllysine; alternate.
N6,N6-dimethyllysine; alternate.
N6-methyllysine; alternate.
N6,N6,N6-trimethyllysine
N6,N6-dimethyllysine
N6-acetyllysine
N6-methyllysine
N6-methylated lysine		
			

		

		
			

				Structure Information
			


		
		
			

				PDB ID Code
				3UVY
			

			

				Model
				-
			

			

				Chain
				B
			

			

				Position
				20
			

			

				SCOP Class
				None
			

			

				MODRES
				N(6)-ACETYLLYSINE                        
			

		

		
			

				Related PTM
			


		
		
			

				Found in same PDB Chain
				16
			

			

				Found in same Uniprot AC
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PDB ID Code
  (idpdb-chain_aa)
Sequence position
  (aa_idpdb-chain)
Gallery (?)
Slide 1
Slide 2
Example Frame 



Note: As the images production is automatic, the focus on the PTM site could not be the most optimized.
      In these cases it is recommended to use the PyMOL script to visualize the PTM site in 3D.
Alignment
(?) 

	           Numerotation

	(?)       Uniprot Sequence
	(?)                Clustal
	(?)           PDB Sequence
	(?)        PDB Information
	(?)          DSSP Sequence
	(?) Protein Block Sequence
	
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MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
               * *** *****                                                                             
---------------AXRHRXVLRDN-----------------------------------------------------------------------------
               _H___H____M                                                                             
               CCCCCCSCCC                                                                              
               ZZccfbdcZZ

Scripts     (PyMol,     Modeller,     ...)

PyMol 
	Download
Modeller 
	
If you want to use this structure as a template for modelisation with Modeller, you can use the following sequence to build the alignment file "*.ali".

To avoid the classical Modeller error :

			'Number of residues in the alignment and pdb files are different'(see FAQ n°17),

the missing residues, non-classical amino-acids, and sequence gaps have been replaced by a "X" symbol.
AXRHRXVLRDX 
1) align this sequence with your sequence to modelised;
2) replace the "X" by "-" in the obtained alignement, then build your "*.ali" file;
3) use Modeller to make your models;
4) And finally use the following information found in the PDB to add this PTM in your models (see FAQ n°8 & 9 and this archive of Modeller usage).
			

			

			
				

REMARK 500    ALY B  20   O   -  C   -  N   ANGL. DEV. = -21.8 DEGREES          
REMARK 500    ALY B  20      -54.14   -140.89                                   
REMARK 500    ALY B  20         33.63                                           
MODRES 3UVY ALY B   20  LYS  N(6)-ACETYLLYSINE                                  
LINK         C   ARG B  19                 N   ALY B  20     1555   1555  1.27  
LINK         C   ALY B  20                 N   VAL B  21     1555   1555  1.32  
HETATM  970  OH  ALY B  20      72.557  24.216  11.364  1.00 31.38           O  
HETATM  971  CH  ALY B  20      73.695  24.479  10.958  1.00 25.67           C  
HETATM  972  CH3 ALY B  20      74.426  23.596  10.007  1.00 30.04           C  
HETATM  973  NZ  ALY B  20      74.341  25.593  11.301  1.00 31.17           N  
HETATM  974  CE  ALY B  20      73.799  26.614  12.211  1.00 34.68           C  
HETATM  975  CD  ALY B  20      74.232  28.035  11.859  1.00 33.89           C  
HETATM  976  CG  ALY B  20      74.245  28.408  10.399  1.00 23.23           C  
HETATM  977  CB  ALY B  20      74.193  29.912  10.131  1.00 17.47           C  
HETATM  978  CA  ALY B  20      75.456  30.460   9.457  1.00 24.56           C  
HETATM  979  N   ALY B  20      76.332  30.940  10.493  1.00 22.92           N  
HETATM  980  C   ALY B  20      75.175  31.561   8.451  1.00 23.96           C  
HETATM  981  O   ALY B  20      74.307  31.317   7.588  1.00 28.24           O