SWift and Optimized Recognition of protein Domains
The SWORD2 partitioning algorithm produces multiple alternative domain assignments for a given protein structure. This unique approach handles ambiguous protein structure partitioning, admitting several solutions. The decomposition of the protein structure into domains is achieved through the hierarchical clustering of Protein Units, evolutionarily preserved structural descriptors at the interface between secondary structures and domains.
Cretin, G., Galochkina, T.,
Vander Meersche, Y., de Brevern, A. G., Postic, G., & Gelly, J. C. (2022).
SWORD2: hierarchical analysis of protein 3D structures. Nucleic acids research, gkac370.
50(W1), W732–W738 10.1093/nar/gkac370
Postic, G., Ghouzam, Y., Chebrek, R., & Gelly, J. C. (2017).
An ambiguity principle for assigning protein structural domains.
Science advances, 3(1), e1600552.10.1126/sciadv.1600552
SWORD2_summary.txt. The original SWORD output is available in