Pour information, un poste d’ingénieur d’étude est disponible dans l’équipe DSIMB, voici la fiche de poste associé :
The IRNH meeting (International Research Network on Hematology) , Université Sorbonne Paris Cité – Université de São Paulo will take place at INTS meeting room on March 7, 8 and 9 mars 2016.
INTS – 6, rue Alexandre Cabanel – Paris 15ème
More information and program on the symposium page.
Discovery of novel bioactive molecules (biologics and small chemical entities) is a complex endeavour and generally involves several years of research and development. During this discovery process several properties of such molecular candidates have to be optimized towards various endpoints, such as activity vs a therapeutic target, ADMET properties, pharmacokinetics without speaking about putative patentability issues. One of the most important hallmarks of a novel bioactive entity is its pattern of intermolecular interactions.
Since the seeding paper on SIFTs (Structural Interaction Fingerprints (Deng, Chuaqui, & Singh, 2004)), several studies have been proposed for the detection and comparison of molecular interactions. (Da & Kireev, 2014; Desaphy, Raimbaud, Ducrot, & Rognan, 2013). CREDO is an example of first attempts to make such information publicly available(A. Schreyer & Blundell, 2009; A. M. Schreyer & Blundell, 2013).
Most of these, as well as similar studies, reduce the representation of a molecular interaction to an easily comparable fingerprint. Unfortunately these representations have inherent drawbacks on querying large databases of molecular interactions and furthermore, none of the methods are easily available for privately held companies as well as for academics interested by high-throughput approaches.
This PhD project aims at providing methodological basics for a large-scale description and analysis of molecular interactions. The underlying methods should be able to describe molecular interactions allowing later comparison of subsets of such descriptions instantaneously when querying a large database. Furthermore, the underlying methods should be able to correctly treat non-curated data, such as available in the Protein Data Bank. Seeding work has been already performed in the scope of binding site comparison (Doppelt-Azeroual, Delfaud, Moriaud, & De Brevern, 2010; Schmidtke, n.d.).
The project is part of a larger development project within Discngine and carried out in collaboration with a major pharmaceutical company.
We are seeking for a highly motivated and autonomous PhD candidate for a period of three years. This PhD project will be supervised by Vincent Le Guilloux, Ph.D. & Peter Schmidtke, Ph.D. Discngine (Paris based privately held company, http://www.discngine.com, publications at https://scholar.google.fr/citations?user=UtOSocMAAAAJ&hl=en) and Alexandre G. de Brevern, Ph.D., D.Sc. from the DSIMB lab (INSERM, Univ Paris Diderot, Sorbonne Paris Cité, INTS, GR-Ex, see publications athttps://scholar.google.fr/citations?user=NB4OJhoAAAAJ&hl=fr). The PhD will be conducted under CIFRE conventions (http://www.anrt.asso.fr/fr/pdf/plaquette_cifre_complete_avril2009_GB.pdf).
The ideal PhD candidate should hold a Master’s degree in bioinformatics, biophysics or informatics with a strong interest on structural biology and perception of intermolecular interactions. Notions of database design / querying, graph-based technologies, graph-theory and molecular perception are required for this positions. Strong programming expertise as well as analytical skills are a must. Previous experience in the area of peptide & small molecular design would facilitate the initial phase of the project.
Please send your curriculum and letter of intent to email@example.com and firstname.lastname@example.org
Expected starting date: Octobre 2015
Duration: 3 years
Location: Paris (France)
Da, C., & Kireev, D. B. (2014). Structural Protein-Ligand Interaction Fingerprints (SPLIF) for Structure-Based Virtual Screening: Method and Benchmark Study. Journal of Chemical Information and Modeling, 140813100524004. doi:10.1021/ci500319f
Deng, Z., Chuaqui, C., & Singh, J. (2004). Structural Interaction Fingerprint (SIFt): A Novel Method for Analyzing Three-Dimensional Protein-Ligand Binding Interactions. Journal of Medicinal Chemistry, 47(2), 337–344. doi:10.1021/jm030331x
Desaphy, J., Raimbaud, E., Ducrot, P., & Rognan, D. (2013). Encoding protein-ligand interaction patterns in fingerprints and graphs. Journal of Chemical Information and Modeling, 53(3), 623–637. doi:10.1021/ci300566n
Doppelt-Azeroual, O., Delfaud, F., Moriaud, F., & De Brevern, A. G. (2010). Fast and automated functional classification with MED-SuMo: An application on purine-binding proteins. Protein Science, 19(4), 847–867. doi:10.1002/pro.364
Schmidtke, P. (n.d.). Protein-ligand binding sites. Identification, characterization and interrelations. Universitat de Barcelona. Retrieved from http://tdx.cat/handle/10803/51340
Schreyer, A., & Blundell, T. (2009). CREDO: A protein-ligand interaction database for drug discovery. Chemical Biology and Drug Design, 73, 157–167. doi:10.1111/j.1747-0285.2008.00762.x
Schreyer, A. M., & Blundell, T. L. (2013). CREDO: A structural interactomics database for drug discovery. Database, 2013. doi:10.1093/database/bat049
Weill, N., & Rognan, D. (2009). Development and validation of a novel protein-ligand fingerprint to mine chemogenomic space: Application to G protein-coupled receptors and their ligands. Journal of Chemical Information and Modeling, 49(4), 1049–1062. doi:10.1021/ci800447g
DSIMB Team organize a meeting on October 2013 21th at 11h30 at the INTS. During it, Dr. Anne Lopes from Institut de Génétique et Microbiologie (UMR 8621 Université Paris Sud) will talk about “Protein-protein interactions in a crowded environment: an analysis via cross-docking simulations and evolutionary information”.
For more information, please contact Catherine Etchebest.
We are organizing a mini-symposium on biological membranes:
Patricia Bassereau (Institut Curie, Paris)
Peter Tieleman (U. Calgary, Canada)
Samuli Ollila (Aalto U., Finland)
James Sturgis (CNRS, Marseille)
Wladimir Urbach (ENS, Paris)
Siewert-Jan Marrink (U. Groningen, The Netherlands)
Ilpo Vattulainen (Tampere U. Technology, Finland)
Jeudi 27 juin 2013, h 9:30
Salle de conferences INTS
Institut National de la Transfusion Sanguine (INTS)
6, rue Alexandre Cabanel, 75015 PARIS
Please register by e-mail: catherine.etchebest[at]inserm.fr or luca.monticelli[at]inserm.fr
Professor Peter Tieleman from Dept. Biological Sciences, University of Calgary, AB, Canada will give a talk Jeudi 25 avril 2013, 10h00 in the INTS conference room.
The subject is : Computational studies of ABC transporters
le 18ème congrès du GGMM (groupe de Graphisme et de Modélisation Moléculaire)
aura lieu du 21 au 23 mai 2013 sur l’ile d’Oléron.
Nous vous invitons à vous inscrire dès maintenant sur le site Web du congrès
http://ggmm2013.wordpress.com/ et à envoyer votre résumé.
Un certain nombre de présentations orales seront sélectionnées sur résumé (date limite d’envoi : vendredi
29 mars 2013).
J O B I M 2 0 1 3
French Conference on Biology, Computer Science and Mathematics
Toulouse, 1 – 4 July 2013
This is the first call for papers for JOBIM 2013.
The annual meeting of the French bioinformatics population, organized
via the SFBI, will hold its 14th edition in Toulouse (1st to 4th July
2013). This year this conference will also be the opportunity to invite
in a privileged manner colleagues from the Catalan region around
The necessary information for submissions and inscriptions can be found
on the conference website:
CALL FOR PAPERS
The last date for propositions to be submitted is the 18th March 2013.
Three categories of submissions are possible:
* original articles (8 to 10 pages), restricted to unpublished results
* extended abstracts(2 to 8 pages), corresponding to recent work under
submission or accepted elsewhere
* short summary (1 to 2 pages), corresponding to recent work or in
progress, already published or not.
The original articles and extended summaries will be selected based on
critical review by at least two members of the program committee and
will be published in the conference proceedings. They will be proposed
for oral presentation (and, if desired by the authors as poster
presentation). The short summaries are destined to be presented only as
As in previous editions, JOBIM will be structured around plenary
sessions as well as thematic parallel sessions so as to increase the
number of possibilities of participants to present their work orally and
to create an informal forum to encourage scientific discussion. The
choice of themes will be decided later on the basis of the selected
contributions. The existence of a parallel session will therefore be
conditioned by the number of quality submissions. If you want particular
themes to be the object of a session please send as many good
propositions as possible and don’t hesitate to encourage colleagues to
We particularly encourage PhD students and post-docs to use this
opportunity to present their work at JOBIM. Awards will be given to the
young scientists giving the best poster and oral presentations.
The themes covered by JOBIM include all the major aspects of
bioinformatics and will include fundamental methodology (mathematical
modeling, computing, statistical analysis and physical methodology), the
software tools and contributions describing specific applications and
ground-breaking research leading to new biological concepts. A
non-exhaustive listing of potential themes is as follows:
* genomics, comparative analysis, metagenomics
* evolution and phylogeny
* biodiversity, genetics and population genomics
* sequence analysis
* cartography and genome annotation
* systems biology and biological networks
* macromolecule structures
* gene expression and functional genomics
* NGS data analysis
* non-coding RNA
* epigenetics and epigenomics
* ontology databases
* data integration
* algorithmics and statistics for bioinformatics
February 1st: Call open for oral communications and poster submissions
March 18th: Closing date for submission of oral and poster
April 29th: Author notification of the decision of the Scientific Committee
May 13th: Final Program announcement
July 1st: Beginning of the JOBIM 2013 conference
All the DSIMB Team congratulates Dr Giulia ROSSI for winning the best poster prize of the 6th International Conference on Multiscale Materials Modeling (MMM2012)
L’ensemble de l’équipe DSIMB félicite Christel GOUDOT pour l’obtention d’une bourse L’Oréal France – Unesco – Académie des sciences.