############################################################################## TOPCONS2 result file Generated from http://commonbackend.computenode.pcons3.se at 2018-10-26 02:30:49 Total request time: 11.4 seconds. ############################################################################## Sequence number: 1 Sequence name: sp|P49768|PSN1_HUMAN Presenilin-1 OS=Homo sapiens OX=9606 GN=PSEN1 PE=1 SV=1 Sequence length: 467 aa. Sequence: MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI TOPCONS predicted topology: iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiMMMMMMMMMMMMMMMMMMMMMooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooooooooo OCTOPUS predicted topology: iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiMMMMMMMMMMMMMMMMMMMMMoooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooo Philius predicted topology: iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMMiiiiiiMMMMMMMMMMMMMMMMMMMMMMMoooooooMMMMMMMMMMMMMMMMMMMMMMMiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooMMMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMooooooMMMMMMMMMMMMMMMMMMMMMMiiiiiiMMMMMMMMMMMMMMMMMMMMoooooooooooooo PolyPhobius predicted topology: iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMMiiiiiiiMMMMMMMMMMMMMMMMMMMMMMoooooooooooMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMoooooMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMMMMooooMMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiii SCAMPI predicted topology: iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiMMMMMMMMMMMMMMMMMMMMMoMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiii SPOCTOPUS predicted topology: iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiMMMMMMMMMMMMMMMMMMMMMoooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooo Homology: No homologous hits found Predicted Delta-G-values (kcal/mol) (left column=sequence position; right column=Delta-G) 10 8.818 11 9.743 12 10.520 13 9.813 14 10.601 15 10.849 16 10.963 17 10.738 18 11.181 19 11.184 20 11.670 21 12.441 22 12.575 23 12.774 24 13.162 25 13.901 26 14.297 27 14.542 28 14.867 29 15.546 30 15.774 31 15.916 32 16.611 33 16.622 34 16.703 35 16.340 36 16.324 37 16.670 38 16.360 39 16.254 40 16.226 41 15.326 42 14.821 43 14.942 44 13.728 45 12.882 46 12.210 47 11.663 48 11.022 49 11.131 50 11.554 51 11.958 52 12.694 53 12.710 54 13.231 55 13.279 56 13.239 57 13.152 58 13.296 59 13.685 60 14.790 61 14.865 62 15.220 63 15.722 64 15.598 65 15.402 66 14.646 67 14.589 68 13.849 69 13.774 70 13.572 71 13.018 72 13.354 73 13.218 74 12.433 75 11.622 76 10.508 77 9.325 78 8.207 79 7.321 80 6.254 81 5.116 82 3.430 83 3.212 84 2.640 85 2.517 86 2.069 87 1.937 88 1.375 89 1.187 90 0.820 91 -0.044 92 0.125 93 0.611 94 0.630 95 1.355 96 1.564 97 1.875 98 1.936 99 2.439 100 3.223 101 4.535 102 5.468 103 6.810 104 7.263 105 7.950 106 8.457 107 8.817 108 9.305 109 9.009 110 8.771 111 8.804 112 8.305 113 8.039 114 8.420 115 8.834 116 8.950 117 9.213 118 9.812 119 9.536 120 9.222 121 8.600 122 8.887 123 9.799 124 9.926 125 9.567 126 10.166 127 9.532 128 9.497 129 8.848 130 7.423 131 6.228 132 5.871 133 4.716 134 4.096 135 3.630 136 2.957 137 2.057 138 1.737 139 1.306 140 0.781 141 -0.661 142 -1.258 143 -1.360 144 -1.313 145 -1.803 146 -1.344 147 -1.136 148 -0.716 149 -0.292 150 0.208 151 0.607 152 1.429 153 2.348 154 3.941 155 4.994 156 5.604 157 5.531 158 5.372 159 5.196 160 5.010 161 4.631 162 3.511 163 2.957 164 2.034 165 0.847 166 0.301 167 -0.238 168 -0.775 169 -0.557 170 -1.204 171 -1.397 172 -1.517 173 -2.638 174 -2.298 175 -1.108 176 -0.354 177 -0.136 178 0.495 179 0.518 180 0.386 181 1.552 182 2.369 183 3.357 184 4.172 185 5.294 186 5.917 187 6.310 188 6.219 189 6.611 190 6.788 191 6.448 192 6.008 193 5.101 194 3.736 195 3.789 196 3.257 197 2.850 198 2.606 199 2.416 200 1.757 201 1.594 202 1.308 203 1.555 204 0.981 205 1.571 206 1.221 207 1.144 208 1.493 209 2.054 210 2.582 211 3.469 212 3.907 213 5.154 214 5.781 215 6.803 216 7.041 217 7.108 218 7.278 219 6.959 220 6.728 221 6.789 222 5.851 223 5.033 224 3.966 225 3.566 226 2.435 227 1.711 228 0.556 229 0.494 230 0.286 231 0.142 232 -0.930 233 -0.767 234 0.422 235 1.019 236 1.929 237 2.648 238 2.988 239 3.221 240 3.182 241 2.950 242 3.507 243 3.448 244 3.058 245 3.410 246 2.838 247 2.327 248 2.264 249 1.206 250 1.019 251 1.131 252 0.688 253 -0.082 254 0.428 255 1.382 256 2.122 257 2.964 258 4.002 259 3.879 260 4.385 261 4.406 262 4.050 263 4.272 264 4.626 265 5.077 266 5.545 267 6.225 268 7.712 269 7.895 270 8.411 271 9.154 272 9.588 273 9.347 274 8.880 275 9.468 276 9.458 277 9.071 278 9.292 279 8.925 280 8.650 281 8.619 282 8.073 283 6.807 284 6.409 285 5.766 286 4.360 287 3.208 288 3.457 289 2.941 290 2.220 291 2.880 292 3.767 293 4.450 294 4.656 295 5.780 296 6.669 297 7.552 298 7.994 299 7.930 300 7.961 301 8.839 302 9.831 303 11.163 304 12.471 305 13.876 306 14.439 307 14.574 308 14.713 309 15.401 310 14.771 311 14.211 312 14.330 313 13.573 314 13.090 315 13.221 316 13.317 317 13.750 318 13.853 319 13.897 320 13.593 321 14.003 322 13.848 323 14.007 324 14.328 325 14.684 326 14.141 327 13.634 328 13.251 329 13.348 330 13.710 331 12.891 332 13.415 333 12.417 334 12.245 335 11.815 336 11.967 337 12.413 338 12.973 339 12.695 340 12.574 341 12.468 342 12.873 343 12.726 344 12.721 345 12.137 346 12.378 347 12.603 348 12.203 349 11.596 350 11.872 351 11.331 352 11.256 353 11.161 354 11.834 355 11.143 356 11.258 357 10.974 358 11.526 359 10.799 360 9.534 361 8.377 362 8.137 363 7.906 364 8.058 365 7.938 366 7.800 367 8.461 368 8.807 369 9.390 370 9.694 371 10.368 372 9.876 373 10.078 374 10.460 375 10.872 376 11.048 377 10.609 378 10.312 379 9.826 380 8.932 381 8.098 382 6.732 383 5.373 384 4.649 385 4.009 386 3.728 387 3.683 388 3.537 389 3.448 390 3.202 391 3.553 392 3.559 393 4.528 394 4.730 395 4.561 396 5.768 397 6.220 398 6.824 399 7.008 400 6.850 401 6.918 402 7.059 403 6.896 404 6.383 405 5.676 406 5.005 407 4.084 408 3.755 409 2.675 410 1.905 411 0.527 412 -0.287 413 -1.159 414 -1.492 415 -2.516 416 -2.858 417 -2.790 418 -2.734 419 -2.994 420 -2.640 421 -1.949 422 -1.578 423 -1.542 424 -0.338 425 0.743 426 1.177 427 2.028 428 2.847 429 3.515 430 3.936 431 3.966 432 3.960 433 4.250 434 3.747 435 3.590 436 2.838 437 2.354 438 1.738 439 1.108 440 0.664 441 1.005 442 1.502 443 1.073 444 1.375 445 2.777 446 3.227 447 3.709 448 3.937 449 4.853 450 5.474 451 5.587 452 5.485 453 5.672 454 6.200 455 6.891 456 6.576 457 6.590 458 6.204 Predicted TOPCONS reliability (left column=sequence position; right column=reliability) 11 100.00 12 100.00 13 100.00 14 100.00 15 100.00 16 100.00 17 100.00 18 100.00 19 100.00 20 100.00 21 100.00 22 100.00 23 100.00 24 100.00 25 100.00 26 100.00 27 100.00 28 100.00 29 100.00 30 100.00 31 100.00 32 100.00 33 100.00 34 100.00 35 100.00 36 100.00 37 100.00 38 100.00 39 100.00 40 100.00 41 100.00 42 100.00 43 100.00 44 100.00 45 100.00 46 100.00 47 100.00 48 100.00 49 100.00 50 100.00 51 100.00 52 100.00 53 100.00 54 100.00 55 100.00 56 100.00 57 100.00 58 100.00 59 100.00 60 100.00 61 100.00 62 100.00 63 100.00 64 100.00 65 100.00 66 100.00 67 100.00 68 100.00 69 100.00 70 100.00 71 100.00 72 97.14 73 97.14 74 97.14 75 97.14 76 97.14 77 97.14 78 97.14 79 97.14 80 97.14 81 97.14 82 97.14 83 97.14 84 97.14 85 97.14 86 97.14 87 97.14 88 97.14 89 97.14 90 97.14 91 97.14 92 97.14 93 99.05 94 99.05 95 99.05 96 99.05 97 99.05 98 99.05 99 99.05 100 99.05 101 99.05 102 99.05 103 99.05 104 99.05 105 99.05 106 99.05 107 99.05 108 99.05 109 99.05 110 99.05 111 99.05 112 99.05 113 99.05 114 100.00 115 100.00 116 100.00 117 100.00 118 100.00 119 100.00 120 100.00 121 100.00 122 100.00 123 100.00 124 100.00 125 100.00 126 100.00 127 100.00 128 100.00 129 100.00 130 100.00 131 100.00 132 100.00 133 100.00 134 100.00 135 100.00 136 100.00 137 100.00 138 100.00 139 100.00 140 100.00 141 100.00 142 100.00 143 100.00 144 98.10 145 98.10 146 98.10 147 98.10 148 98.10 149 98.10 150 98.10 151 97.14 152 97.14 153 97.14 154 97.14 155 97.14 156 97.14 157 97.14 158 97.14 159 97.14 160 97.14 161 97.14 162 97.14 163 97.14 164 97.14 165 99.05 166 99.05 167 99.05 168 99.05 169 99.05 170 99.05 171 99.05 172 100.00 173 98.10 174 98.10 175 98.10 176 98.10 177 98.10 178 98.10 179 98.10 180 98.10 181 97.14 182 96.19 183 95.24 184 93.33 185 93.33 186 93.33 187 93.33 188 93.33 189 93.33 190 93.33 191 93.33 192 93.33 193 93.33 194 95.24 195 95.24 196 95.24 197 95.24 198 95.24 199 95.24 200 95.24 201 95.24 202 96.19 203 97.14 204 96.19 205 97.14 206 97.14 207 97.14 208 97.14 209 95.24 210 92.38 211 91.43 212 91.43 213 91.43 214 91.43 215 91.43 216 91.43 217 91.43 218 91.43 219 91.43 220 91.43 221 91.43 222 91.43 223 91.43 224 91.43 225 93.33 226 94.29 227 94.29 228 94.29 229 94.29 230 94.29 231 95.24 232 96.19 233 95.24 234 94.29 235 92.38 236 92.38 237 92.38 238 92.38 239 92.38 240 92.38 241 92.38 242 92.38 243 92.38 244 92.38 245 92.38 246 92.38 247 92.38 248 92.38 249 92.38 250 92.38 251 94.29 252 96.19 253 96.19 254 96.19 255 95.24 256 96.19 257 95.24 258 94.29 259 94.29 260 94.29 261 94.29 262 94.29 263 94.29 264 94.29 265 94.29 266 94.29 267 94.29 268 94.29 269 94.29 270 94.29 271 94.29 272 94.29 273 94.29 274 94.29 275 95.24 276 97.14 277 98.10 278 99.05 279 100.00 280 100.00 281 100.00 282 100.00 283 100.00 284 100.00 285 100.00 286 100.00 287 100.00 288 100.00 289 100.00 290 100.00 291 100.00 292 100.00 293 100.00 294 100.00 295 100.00 296 100.00 297 100.00 298 100.00 299 100.00 300 100.00 301 100.00 302 100.00 303 100.00 304 100.00 305 100.00 306 100.00 307 100.00 308 100.00 309 100.00 310 100.00 311 100.00 312 100.00 313 100.00 314 100.00 315 100.00 316 100.00 317 100.00 318 100.00 319 100.00 320 100.00 321 100.00 322 100.00 323 100.00 324 100.00 325 100.00 326 100.00 327 100.00 328 100.00 329 100.00 330 100.00 331 100.00 332 100.00 333 100.00 334 100.00 335 100.00 336 100.00 337 100.00 338 100.00 339 100.00 340 100.00 341 100.00 342 100.00 343 100.00 344 100.00 345 100.00 346 100.00 347 100.00 348 100.00 349 100.00 350 100.00 351 100.00 352 100.00 353 100.00 354 100.00 355 100.00 356 100.00 357 100.00 358 100.00 359 100.00 360 100.00 361 100.00 362 100.00 363 100.00 364 100.00 365 100.00 366 100.00 367 100.00 368 100.00 369 97.14 370 94.29 371 92.38 372 90.48 373 88.57 374 86.67 375 84.76 376 82.86 377 80.95 378 79.05 379 77.14 380 75.24 381 73.33 382 71.43 383 69.52 384 67.62 385 65.71 386 63.81 387 61.90 388 60.00 389 58.10 390 59.05 391 60.00 392 60.00 393 60.00 394 60.00 395 60.00 396 60.95 397 62.86 398 64.76 399 66.67 400 68.57 401 70.48 402 72.38 403 74.29 404 76.19 405 78.10 406 80.00 407 81.90 408 83.81 409 85.71 410 87.62 411 89.52 412 91.43 413 93.33 414 95.24 415 97.14 416 99.05 417 97.14 418 95.24 419 93.33 420 91.43 421 89.52 422 87.62 423 85.71 424 83.81 425 83.81 426 83.81 427 83.81 428 83.81 429 83.81 430 83.81 431 83.81 432 83.81 433 83.81 434 83.81 435 83.81 436 83.81 437 83.81 438 86.67 439 88.57 440 90.48 441 92.38 442 94.29 443 95.24 444 95.24 445 93.33 446 91.43 447 89.52 448 87.62 449 85.71 450 83.81 451 81.90 452 80.00 453 78.10 454 76.19 455 74.29 456 72.38 ##############################################################################