############################################################################## TOPCONS2 result file Generated from http://commonbackend.computenode.pcons3.se at 2018-10-26 16:27:14 Total request time: 8.0 seconds. ############################################################################## Sequence number: 1 Sequence name: sp|Q96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A OS=Homo sapiens OX=9606 GN=APH1A PE=1 SV=1 Sequence length: 265 aa. Sequence: MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED TOPCONS predicted topology: iiiiMMMMMMMMMMMMMMMMMMMMMoooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMMooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii OCTOPUS predicted topology: iMMMMMMMMMMMMMMMMMMMMMoooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii Philius predicted topology: ooooMMMMMMMMMMMMMMMMMMMMMMiiiiiiMMMMMMMMMMMMMMMMMMMMMMMMMoooooooooMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMMooooooooooooooooMMMMMMMMMMMMMMMMMMMMMMMiiiiiiiiMMMMMMMMMMMMMMMMMMMMoooooooMMMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiii PolyPhobius predicted topology: oooooMMMMMMMMMMMMMMMMMMMMiiiiiiMMMMMMMMMMMMMMMMMMMMMMMMMooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooMMMMMMMMMMMMMMMMMMMMMMMMiiiiiiiMMMMMMMMMMMMMMMMMMMMoooooMMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii SCAMPI predicted topology: iiiiiMMMMMMMMMMMMMMMMMMMMMooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii SPOCTOPUS predicted topology: iMMMMMMMMMMMMMMMMMMMMMooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiMMMMMMMMMMMMMMMMMMMMMoooooMMMMMMMMMMMMMMMMMMMMMiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii Homology: No homologous hits found Predicted Delta-G-values (kcal/mol) (left column=sequence position; right column=Delta-G) 10 1.610 11 1.252 12 0.757 13 0.483 14 0.398 15 0.430 16 0.636 17 0.749 18 0.719 19 1.051 20 1.452 21 1.429 22 1.647 23 1.858 24 2.328 25 2.287 26 1.798 27 2.160 28 2.755 29 3.283 30 3.704 31 3.570 32 3.151 33 2.293 34 1.057 35 0.317 36 0.216 37 -0.720 38 -1.263 39 -1.685 40 -1.077 41 -0.621 42 -0.512 43 -0.416 44 -0.640 45 -0.682 46 -1.032 47 -1.713 48 -2.218 49 -1.722 50 -1.267 51 -0.810 52 0.104 53 0.846 54 1.451 55 2.062 56 3.014 57 3.986 58 4.616 59 6.012 60 6.446 61 7.553 62 7.974 63 8.159 64 8.503 65 8.182 66 8.212 67 7.432 68 5.840 69 4.943 70 4.516 71 3.366 72 2.529 73 1.343 74 1.159 75 1.548 76 1.525 77 1.613 78 1.405 79 1.568 80 1.623 81 2.149 82 2.748 83 3.374 84 3.811 85 3.825 86 4.875 87 5.783 88 6.327 89 6.889 90 8.025 91 9.128 92 9.507 93 9.412 94 9.248 95 8.934 96 9.135 97 9.536 98 9.921 99 9.887 100 9.677 101 9.833 102 9.643 103 9.758 104 10.363 105 9.989 106 9.813 107 10.381 108 10.080 109 9.263 110 8.722 111 8.575 112 8.484 113 7.956 114 7.853 115 7.653 116 6.645 117 6.322 118 5.399 119 4.792 120 4.445 121 3.966 122 3.753 123 2.903 124 3.080 125 2.765 126 2.092 127 2.799 128 2.783 129 2.611 130 2.557 131 2.722 132 2.510 133 2.792 134 3.150 135 4.320 136 4.604 137 5.048 138 5.386 139 5.474 140 5.187 141 5.815 142 6.408 143 6.183 144 6.333 145 6.794 146 5.950 147 5.942 148 6.016 149 5.785 150 5.791 151 6.584 152 7.349 153 7.121 154 6.361 155 5.972 156 5.834 157 5.567 158 4.732 159 4.147 160 2.556 161 1.239 162 1.097 163 0.438 164 -0.234 165 -0.402 166 -0.074 167 0.146 168 0.477 169 0.291 170 -0.198 171 0.355 172 0.840 173 1.307 174 2.100 175 2.258 176 2.438 177 2.772 178 3.078 179 3.645 180 4.420 181 4.368 182 5.812 183 6.951 184 7.844 185 7.779 186 7.775 187 7.232 188 6.973 189 5.731 190 3.978 191 3.006 192 2.600 193 1.587 194 1.173 195 1.433 196 1.615 197 1.870 198 2.959 199 3.787 200 4.290 201 4.040 202 5.183 203 5.362 204 5.873 205 5.577 206 5.025 207 4.895 208 5.283 209 5.386 210 5.138 211 4.475 212 4.042 213 4.122 214 4.159 215 4.123 216 4.396 217 3.182 218 2.316 219 2.287 220 1.778 221 1.042 222 1.012 223 0.629 224 1.264 225 2.003 226 2.068 227 2.121 228 2.297 229 2.775 230 2.697 231 3.013 232 3.087 233 3.352 234 3.546 235 3.624 236 4.697 237 5.476 238 5.809 239 6.870 240 7.845 241 8.272 242 8.809 243 8.797 244 8.765 245 8.812 246 9.611 247 9.688 248 9.634 249 9.387 250 8.255 251 7.869 252 6.943 253 7.122 254 7.509 255 7.881 256 8.086 Predicted TOPCONS reliability (left column=sequence position; right column=reliability) 11 84.76 12 86.67 13 88.57 14 90.48 15 92.38 16 91.43 17 89.52 18 87.62 19 85.71 20 83.81 21 81.90 22 80.00 23 78.10 24 75.24 25 75.24 26 75.24 27 75.24 28 75.24 29 75.24 30 75.24 31 75.24 32 75.24 33 75.24 34 77.14 35 79.05 36 80.95 37 83.81 38 85.71 39 87.62 40 89.52 41 91.43 42 93.33 43 95.24 44 97.14 45 99.05 46 97.14 47 95.24 48 93.33 49 91.43 50 89.52 51 87.62 52 85.71 53 83.81 54 81.90 55 80.00 56 78.10 57 76.19 58 74.29 59 72.38 60 71.43 61 71.43 62 71.43 63 71.43 64 71.43 65 71.43 66 72.38 67 74.29 68 76.19 69 78.10 70 80.00 71 81.90 72 83.81 73 85.71 74 87.62 75 89.52 76 91.43 77 92.38 78 93.33 79 94.29 80 95.24 81 94.29 82 92.38 83 90.48 84 88.57 85 86.67 86 84.76 87 82.86 88 80.95 89 79.05 90 77.14 91 75.24 92 73.33 93 71.43 94 69.52 95 67.62 96 65.71 97 63.81 98 62.86 99 61.90 100 60.95 101 60.00 102 60.00 103 60.00 104 60.00 105 60.00 106 60.00 107 60.00 108 60.00 109 60.00 110 60.00 111 60.00 112 60.00 113 60.00 114 60.00 115 60.00 116 60.00 117 60.00 118 60.00 119 60.00 120 60.00 121 60.00 122 60.00 123 60.00 124 60.00 125 60.00 126 60.00 127 60.00 128 60.00 129 60.95 130 62.86 131 64.76 132 66.67 133 68.57 134 70.48 135 72.38 136 74.29 137 76.19 138 78.10 139 80.00 140 81.90 141 83.81 142 85.71 143 87.62 144 89.52 145 91.43 146 91.43 147 91.43 148 93.33 149 95.24 150 96.19 151 96.19 152 96.19 153 96.19 154 96.19 155 96.19 156 96.19 157 96.19 158 96.19 159 96.19 160 96.19 161 96.19 162 96.19 163 96.19 164 96.19 165 96.19 166 96.19 167 98.10 168 100.00 169 99.05 170 99.05 171 99.05 172 99.05 173 99.05 174 99.05 175 99.05 176 98.10 177 96.19 178 96.19 179 96.19 180 96.19 181 96.19 182 96.19 183 96.19 184 96.19 185 96.19 186 96.19 187 96.19 188 96.19 189 96.19 190 97.14 191 97.14 192 97.14 193 97.14 194 97.14 195 97.14 196 97.14 197 95.24 198 95.24 199 95.24 200 95.24 201 95.24 202 94.29 203 93.33 204 93.33 205 93.33 206 93.33 207 93.33 208 93.33 209 93.33 210 93.33 211 93.33 212 93.33 213 93.33 214 93.33 215 93.33 216 93.33 217 93.33 218 96.19 219 98.10 220 98.10 221 98.10 222 98.10 223 99.05 224 99.05 225 98.10 226 97.14 227 97.14 228 97.14 229 97.14 230 97.14 231 97.14 232 97.14 233 97.14 234 97.14 235 97.14 236 97.14 237 97.14 238 97.14 239 97.14 240 97.14 241 97.14 242 97.14 243 97.14 244 97.14 245 98.10 246 99.05 247 100.00 248 100.00 249 100.00 250 100.00 251 100.00 252 100.00 253 100.00 254 100.00 ##############################################################################