The SWORD1 partitioning algorithm is capable of producing multiple alternative domain assignments for a given protein structure. This unique approach is aimed at treating ambiguous cases of protein structure partitioning, which can admit several solutions. The decomposition of the protein structure into domains is achieved through the hierarchical clustering of Protein Units2, which are evolutionarily preserved3 structural descriptors of intermediate size, between secondary structures and domains.
1Cretin, G., Galochkina, T., Vander Meersche, Y., de Brevern, A. G., Postic, G. and Gelly, J-C Nucleic Acid Research (2017) 50(W1), W732–W738
1Postic G, Ghouzam Y, Chebrek R, Gelly J-C. Science Advances (2017) 3:e1600552
2Gelly J-C, de Brevern AG, Hazout S. Bioinformatics (2006) 22:129-133
3Gelly J-C, Lin H-Y, de Brevern AG, Chuang T-J, Chen F-C. Genome Biol Evol (2012) 4:966-975
1Cretin, G., Galochkina, T., Vander Meersche, Y., de Brevern, A. G., Postic, G. and Gelly, J-C Nucleic Acid Research (2017) 50(W1), W732–W738
1Postic G, Ghouzam Y, Chebrek R, Gelly J-C. Science Advances (2017) 3:e1600552
2Gelly J-C, de Brevern AG, Hazout S. Bioinformatics (2006) 22:129-133
3Gelly J-C, Lin H-Y, de Brevern AG, Chuang T-J, Chen F-C. Genome Biol Evol (2012) 4:966-975
© 2016 Guillaume Postic, Yassine Ghouzam & Jean-Christophe Gelly; Inserm UMR_S 1134, Univ. Paris Diderot, Sorbonne Paris Cité