Alexandre G. de Brevern's scientific communications and posters
Year 2010
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de Brevern A.G.
Structural Modeling of DARC
Invitation of Laboratory of Informatics and Chemistry, Institute of Chemical Technology (Prague, Czech Republic) (10 December 2010)
Invited Talk given by de Brevern A.G. [PI-34]
DARC (Duffy Antigen Receptor for Chemokines) is unusual transmembrane chemokine receptor which (i) binds the two main chemokine families and (ii) does not transduct any signal as it lacks the DRY consensus sequence. It is considered as silent chemokine receptor, a tank useful for chemiotactism. DARC had been particularly studied as a major actor of malaria infection by Plasmodium vivax. It is also implicated in multiple chemokine inflammation, inflammatory diseases, in cancer and might play a role in HIV infection and AIDS. In this review, we focus on the interest to build structural model of DARC to understand more precisely its abilities to bind its physiological ligand CXCL8 and its malaria ligand. We also present innovative development on VHHs able to bind DARC protein. We underline difficulties and limitations of such bioinformatics approaches and highlight the crucial importance of biological data to conduct these kinds of researches.
Alexandre G. de Brevern
Last Modification : January 2014
Last Modification : January 2014
