PredyFlexy software 1.3.1

The team

   All developpements have done in DSIMB lab (Structural Dynamics and Interactions of Biological Macromolecules). DSIMB is a Bioinformatic Team devoted to different thematics (protein structure analysis, molecular modelling, molecular dynamics, protein docking, methodological developpements...). The team is directed by Pr. Catherine Etchebest.

   The unit is a mixed unit between French National Institute of Health and Medical Research (INSERM) and University Paris Diderot, we are located at the French National Institute of Institute of Blood Transfusion (INTS). We are the second team of INSERM UMR-S 1134 unit directed by Yves Colin.   

The people

   Developpments on local protein conformations have begun under the guidance of Pr. Serge Hazout by Dr. Alexandre G. de Brevern with Pr. Catherine Etchebest [1].
   The improvements of long structural prototypes (LSPs) prediction [2] and flexibility prediction was done by Dr. Aurelie Bornot during her PhD with Dr. Alexandre G. de Brevern and Pr. Catherine Etchebest [3].
   Dr. Jean-Christophe Gelly and Dr. Pierrick Craveur, MSc participated with them to the proposition of a dedicated webserver [4].
   This last version of the software was done with the extra help of Mr. Sylvain Leonard, MSc, Mr. Tarun J. Narwani, MSc and Dr. Joseph Rebehmed [5].

Contact us

   You can contact us, please change " ABC " by :"@"

      Alexandre.De-Brevern ABC inserm.fr for Alexandre G. de Brevern
      Catherine.Etchebest ABC inserm.fr for Catherine Etchebest
      Jean-Christophe.Gelly ABC inserm.fr for Jean-Christophe Gelly
      Pierre.Poulain ABC inserm.fr for Pierre Poulain
      tjrnarwani ABC gmail.com for Tarun J. Narwani
      rebehmed ABC gmail.com for Joseph Rebehmed
      Pierrick.Craveur ABC gmail.com for Pierrick.Craveur
      Sylvain.Leonard ABC inserm.fr for Sylvain Leonard

Some other tools of DSIMB

  • A prediction of Protein Blocks (Java) is proposed here : LocPred..
  • iPBA (protein 3D structure superimposition and PDB mining).
  • Protein Peeling 3 (assignment of Protein Units).
  • Links to KAKSI (assignment of secondary structures). [a local page can be found here]
  • PredyFlexy (prediction of protein flexibility).
  • PBE (Protein Block Expert website).

  • For a complete list see DSIMB tool page

Some references

  1. de Brevern A.G. , Etchebest C., Hazout S.
    Bayesian probabilistic approach for predicting backbone structures in terms of protein blocks
    Proteins (2000) 41, 271-287

  2. Bornot A., Etchebest C., de Brevern A.G.
    A new prediction strategy for long local protein structures using an original description
    Proteins (2009) 76(3):570-87.

  3. Bornot A., Etchebest C., de Brevern A.G.
    Predicting Protein Flexibility through the Prediction of Local Structures.
    Proteins (2011)79(3):839-52.

  4. de Brevern A.G.*, Bornot A.*, Craveur P., Etchebest C., Gelly J.-C.
    PredyFlexy: Flexibility and Local Structure prediction from sequence
    Nucleic Acid Res (2012) 40:W317-22.
    *: authors contribute equally.

  5. Narwani T.J.*.,Etchebest C.*, Craveur P., Leonard S., Rebehmed J., Bornot A., Gelly J.-C., de Brevern A.G.
    in silico prediction of protein flexibility with local structure approach
    submitted (2016) .
    *: authors contribute equally.




      Alexandre G. de Brevern
      Last Modification : July 2016
      Paris7 Inserm INTS