My research topics are methodological developments in structural bioinformatics and more specifically in methods for protein structure exploration, analysis and prediction. A major project that I have developed since the beginning of my career is the concept of Protein Unit. This original concept offers a new level of description for the analysis and prediction of protein structure. It opens a very large field of applications in biology such as protein design, a crucial field in biomedicine. Currently, I am developing methods based on Artificial Intelligence and applying them to different biological questions of importance.