Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
Organism: Escherichia coli
Model: Experimental
Representation: Atomistic
Type: α-helical
Pfam Acc: PF00873
PDB ID: 4DX5
Membrane assignment:
Output PDB file Download
Hydrophobic thickness = 25.5 Å
Number of TM segments = 36
Sequence positions:
A: 10-26|341-358|362-385|397-412|441-456|470-489|538-554|876-892|894-915|929-945|972-989|1004-1026
C: 10-26|343-360|362-383|396-411|441-458|470-489|541-557|873-891|898-919|927-944|974-991|1003-1019
B: 11-28|337-354|366-385|394-410|441-457|470-489|542-559|874-891|898-921|926-943|977-993|1000-1018
Tilt angles:
A - Segment: 10-26 - Tilt: 11.5°
A - Segment: 341-358 - Tilt: 24.3°
A - Segment: 362-385 - Tilt: 52.1°
A - Segment: 397-412 - Tilt: 4.7°
A - Segment: 441-456 - Tilt: 9.8°
A - Segment: 470-489 - Tilt: 26.0°
A - Segment: 538-554 - Tilt: 6.4°
A - Segment: 876-892 - Tilt: 3.0°
A - Segment: 894-915 - Tilt: 49.5°
A - Segment: 929-945 - Tilt: 11.4°
A - Segment: 972-989 - Tilt: 20.5°
A - Segment: 1004-1026 - Tilt: 40.2°
C - Segment: 10-26 - Tilt: 17.0°
C - Segment: 343-360 - Tilt: 17.8°
C - Segment: 362-383 - Tilt: 46.9°
C - Segment: 396-411 - Tilt: 4.7°
C - Segment: 441-458 - Tilt: 26.2°
C - Segment: 470-489 - Tilt: 33.4°
C - Segment: 541-557 - Tilt: 10.5°
C - Segment: 873-891 - Tilt: 28.8°
C - Segment: 898-919 - Tilt: 46.4°
C - Segment: 927-944 - Tilt: 14.1°
C - Segment: 974-991 - Tilt: 21.5°
C - Segment: 1003-1019 - Tilt: 16.1°
B - Segment: 11-28 - Tilt: 26.3°
B - Segment: 337-354 - Tilt: 14.6°
B - Segment: 366-385 - Tilt: 36.5°
B - Segment: 394-410 - Tilt: 6.4°
B - Segment: 441-457 - Tilt: 3.1°
B - Segment: 470-489 - Tilt: 28.1°
B - Segment: 542-559 - Tilt: 23.4°
B - Segment: 874-891 - Tilt: 28.2°
B - Segment: 898-921 - Tilt: 47.5°
B - Segment: 926-943 - Tilt: 25.7°
B - Segment: 977-993 - Tilt: 25.2°
B - Segment: 1000-1018 - Tilt: 35.3°
Structural assessment:
MAIDEN score = -517.3610
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.
Scores for all residue pairs Download
[creation date: Sep-08-2016]